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Text
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URL Address
<a href="http://doi.org/10.1016/s0006-8993(00)02511-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)02511-7</a>
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Pages
160-171
Issue
1
Volume
872
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Title
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Estrogen modulates responses of striatal dopamine neurons to MPP+: evaluations using in vitro and in vivo techniques
Publisher
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Brain Research
Date
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2000
2000-07
Subject
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Neurosciences & Neurology; transporter; brain; neurotoxicity; Neuroprotection; cd-1 mice; nucleus-accumbens; sex-differences; estradiol; mptp-induced neurotoxicity; nigrostriatal; release; 17-beta-estradiol; anesthetized rat; electrochemistry; rat dorsal striatum; superfusion
Creator
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Arvin M; Fedorkova L; Disshon K A; Dluzen D E; Leipheimer R E
Description
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In vitro superfusion and in vivo electrochemistry were used to investigate the role of estrogen in modulatings MPP+-induced dopamine output in the corpus striatum and nucleus accumbens of ovariectomized female rats. For in vitro superfusion experiments, dopamine and dihydroxyphenylacetic acid release were determined using HPLC with electrochemical detection from superfusion of corpus striatum fragments with Kreb's ringer phosphate buffer pulsed with MPP+ alone or MPP+ with estrogen. The in vivo electrochemistry experiments recorded the dopamine signal from carbon fiber microelectrodes stereotaxically passed through the corpus striatum and nucleus accumbens. Dopamine release was stimulated by pressure ejection of MPP+ alone or in combination with estrogen through glass micropipettes fastened to the electrodes. Dopamine output from superfusion chambers which received infusion of MPP+ with estrogen showed significantly lower output of dopamine compared with chambers which received MPP+ alone. Outputs of dihydroxyphenylacetic acid did not increase following MPP+ infusions. Data from the electrochemistry experiments demonstrated that estrogen significantly reduced both the amplitude and clearance rates of the MPP+-evokrd dopamine signal in both the corpus striatum and nucleus accumbens. Results of this study demonstrate that: (1) MPP+ evokes striatal dopamine release and this effect is significantly reduced in the presence of estrogen as determined by both in vivo electrochemistry and in vitro superfusion: (2) similar, albeit attenuated effects are observed in the nucleus accumbens as determined with in vivo electrochemistry; (3) estrogen acts to inhibit the clearance of dopamine in both the striatum and nucleus accumbens: and (4) estrogen may function as a neuroprotectant by reducing the uptake of neurotoxin into dopaminergic neurons. (C) 2000 Elsevier Science B.V. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/s0006-8993(00)02511-7" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)02511-7</a>
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Journal Article or Conference Abstract Publication
17-beta-estradiol
2000
anesthetized rat
Arvin M
Brain
Brain research
cd-1 mice
Disshon K A
Dluzen D E
Electrochemistry
estradiol
Fedorkova L
Journal Article or Conference Abstract Publication
Leipheimer R E
mptp-induced neurotoxicity
Neuroprotection
Neurosciences & Neurology
Neurotoxicity
nigrostriatal
nucleus-accumbens
rat dorsal striatum
release
sex-differences
superfusion
transporter