1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1073/pnas.0505256102" target="_blank" rel="noreferrer noopener">http://doi.org/10.1073/pnas.0505256102</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
18129-18134
Issue
50
Volume
102
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Reduced Paneth cell alpha-defensins in ileal Crohn's disease
Publisher
An entity responsible for making the resource available
Proceedings of the National Academy of Sciences of the United States of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-12
Subject
The topic of the resource
bacteria; expression; gene; human intestinal defensin; inflammatory bowel disease; inflammatory bowel disease; innate; innate immunity; intestine; mechanisms; microflora; mutations; peptides; Science & Technology - Other Topics
Creator
An entity primarily responsible for making the resource
Wehkamp J; Salzman N H; Porter E; Nuding S; Weichenthal M; Petras R E; Shen B; Schaeffeler E; Schwab M; Linzmeier R; Feathers R W; Chu H T; Lima H; Fellermann K; Ganz T; Stange E F; Bevins C L
Description
An account of the resource
The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the small intestine, including human alpha-defensins HD5 and HD6. We tested the hypothesis that reduced expression of PC alpha-defensins compromises mucosal host defenses and predisposes patients to CD of the ileum. We report that patients with CID of the ileum have reduced antibacterial activity in their intestinal mucosal extracts. These specimens also showed decreased expression of PC alpha-defensins, whereas the expression of eight other PC products either remained unchanged or increased when compared with controls. The specific decrease of alpha-defensins was independent of the degree of inflammation in the specimens and was not observed in either CD of the colon, ulcerative colitis, or pouchitis. The functional consequence of alpha-defensin expression levels was examined by using a transgenic mouse model, where we found changes in HD5 expression levels, comparable to those observed in CD, had a pronounced impact on the luminal microbiota. Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1073/pnas.0505256102" target="_blank" rel="noreferrer noopener">10.1073/pnas.0505256102</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
Bacteria
Bevins C L
Chu H T
expression
Feathers R W
Fellermann K
Ganz T
gene
human intestinal defensin
inflammatory bowel disease
Innate
Innate immunity
Intestine
Journal Article
Lima H
Linzmeier R
mechanisms
microflora
mutations
Nuding S
Peptides
Petras R E
Porter E
Proceedings of the National Academy of Sciences of the United States of America
Salzman N H
Schaeffeler E
Schwab M
Science & Technology - Other Topics
Shen B
Stange E F
Wehkamp J
Weichenthal M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00054725-200604002-00040" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00054725-200604002-00040</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S20-S20
Volume
12
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Reduced paneth cell alpha-defensins and antimicrobial activity in ileal Crohn's disease
Publisher
An entity responsible for making the resource available
Inflammatory Bowel Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-04
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Wehkamp J; Salzman N H; Porter E; Nuding S; Weichenthal M; Petras R E; Schaeffeler E; Schwab M; Linzmeier R; Feathers R W; Chu H T; Lima H; Fellermann K; Ganz T; Stange E F; Bevins C L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00054725-200604002-00040" target="_blank" rel="noreferrer noopener">10.1097/00054725-200604002-00040</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
Bevins C L
Chu H T
Feathers R W
Fellermann K
Ganz T
Gastroenterology & Hepatology
Inflammatory Bowel Diseases
Journal Article
Lima H
Linzmeier R
Nuding S
Petras R E
Porter E
Salzman N H
Schaeffeler E
Schwab M
Stange E F
Wehkamp J
Weichenthal M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A30-A31
Issue
4
Volume
101
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Decreased Paneth cell defensins and antimicrobial activity in ileal Crohn's disease
Publisher
An entity responsible for making the resource available
Medizinische Klinik
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-04
Subject
The topic of the resource
General & Internal Medicine
Creator
An entity primarily responsible for making the resource
Wehkamp J; Salzman N; Porter E; Nuding S; Weichenthal M; Petras R; Shen B; Schaffeler E; Schwab M; Fellermann K; Ganz T; Stange E; Bevins C
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
Bevins C
Fellermann K
Ganz T
General & Internal Medicine
Journal Article
Medizinische Klinik
Nuding S
Petras R
Porter E
Salzman N
Schaffeler E
Schwab M
Shen B
Stange E
Wehkamp J
Weichenthal M