1 40 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/s0024-3205(96)00513-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(96)00513-9</a> Pages PL303–308 Issue 20 Volume 59 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Phentermine+fenfluramine produce cocaine-like discriminative cues. Publisher An entity responsible for making the resource available Life sciences Date A point or period of time associated with an event in the lifecycle of the resource 1996 1905-06 Subject The topic of the resource *Discrimination (Psychology); Animals; Cocaine/*pharmacology; Dose-Response Relationship; Drug; Fenfluramine/administration & dosage/*pharmacology; Male; Phentermine/administration & dosage/*pharmacology; Rats; Sprague-Dawley Creator An entity primarily responsible for making the resource Schechter M D; McBurney D Description An account of the resource Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine + fenfluramine. Once having reached criterion performance, these rats were tested with lower doses of cocaine and generated a typical dose-response curve allowing for calculation of an ED50 value: 2.798 mg/kg. Testing of phentermine in doses of 1.25-5.0 mg/kg indicated generalization with the highest dose producing 80% cocaine-appropriate responding and allowing for an ED50 value of 2.356 mg/kg. When the phentermine doses were tested in combination 2.0 mg/kg fenfluramine, however, there was an increase in the discriminability of the highest phentermine dose and a slight decrease in the ED50 value of the combination. Thus, administration of phentermine + fenfluramine, having both dopamine-releasing and serotonin-releasing properties, respectively, may mimic the neurochemical activity by which cocaine acts in the central nervous system and may possibly allow for cocaine-like effects as these two drugs see increased use in obesity control. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/s0024-3205(96)00513-9" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(96)00513-9</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Discrimination (Psychology) 1996 Animals Cocaine/*pharmacology Department of Anatomy & Neurobiology Dose-Response Relationship Drug Fenfluramine/administration & dosage/*pharmacology Life sciences Male McBurney D NEOMED College of Medicine Phentermine/administration & dosage/*pharmacology Rats Schechter M D Sprague-Dawley Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(96)00668-6</a> Pages PL83–90 Issue 6 Volume 60 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Serotonergic mediation of fenfluramine discriminative stimuli in fawn-hooded rats. Publisher An entity responsible for making the resource available Life sciences Date A point or period of time associated with an event in the lifecycle of the resource 1997 1905-06 Subject The topic of the resource *Discrimination Learning; 4-methylenedioxyamphetamine/pharmacology; Animals; Dose-Response Relationship; Drug; Fenfluramine/administration & dosage/*pharmacology; Fluoxetine/pharmacology; Ibogaine/pharmacology; Male; Methoxydimethyltryptamines/pharmacology; N-Methyl-3; Piperazines/pharmacology; Quipazine/pharmacology; Rats; Serotonin Agents/administration & dosage/*pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin/*metabolism; Sprague-Dawley Creator An entity primarily responsible for making the resource Schechter M D Description An account of the resource Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more frequently used strain of Sprague-Dawley rat in its ability to learn to discriminate 2.0 mg/kg fenfluramine administered intraperitoneally. In addition, drugs presumed to work upon central serotonergic neurons were given to the fenfluramine-trained Fawn-Hooded rats to investigate if the cueing properties of the training drug generalized to other agents. Results indicate that the Fawn-Hooded rats learn to discriminate fenfluramine from its vehicle at the same rate, and with a similar sensitivity to lower doses, as do the Sprague-Dawley rats. Furthermore, fenfluramine was shown to completely generalize to MDMA (over 90%); TFMPP, m-CPP, quipazine and fluoxetine produced intermediate results (over 70%) and 5-MeODMT and ibogaine were vehicle-like (less than 70%). As these results coincide with those previously found in Sprague-Dawley rats, the conclusion is that the functional capacity to discriminate fenfluramine appears to be like that of other rat lines, and serotonergically-mediated, in the Fawn-Hooded rat. Suggestions to explain these results are offered and discussed. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(96)00668-6</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Discrimination Learning 1997 4-methylenedioxyamphetamine/pharmacology Animals Dose-Response Relationship Drug Fenfluramine/administration & dosage/*pharmacology Fluoxetine/pharmacology Ibogaine/pharmacology Life sciences Male Methoxydimethyltryptamines/pharmacology N-Methyl-3 Piperazines/pharmacology Quipazine/pharmacology Rats Schechter M D Serotonin Agents/administration & dosage/*pharmacology Serotonin Receptor Agonists/pharmacology Serotonin/*metabolism Sprague-Dawley