1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/s0166-2236(98)01339-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0166-2236(98)01339-3</a> Pages 180–184 Issue 4 Volume 22 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Why adult mammalian intrafusal and extrafusal fibers contain different myosin heavy-chain isoforms. Publisher An entity responsible for making the resource available Trends in neurosciences Date A point or period of time associated with an event in the lifecycle of the resource 1999 1999-04 Subject The topic of the resource *Muscle Development; Afferent Pathways/physiology; Aging/metabolism; Animals; Cell Lineage; Developmental; Fetal Proteins/metabolism; Gene Expression Regulation; Knockout; Mammals/anatomy & histology/*metabolism; Mice; Morphogenesis; Muscle; Muscle Contraction; Muscle Fibers; Muscle Proteins/deficiency/physiology; Muscle Spindles/physiology; Myosin Heavy Chains/*metabolism; Nerve Tissue Proteins/deficiency/physiology; Protein Isoforms/*metabolism; Rats; Skeletal/*chemistry/classification; Skeletal/chemistry/embryology/*growth & development/ultrastructure; Transgenic Creator An entity primarily responsible for making the resource Walro J M; Kucera J Description An account of the resource Multiple isoforms of the contractile protein myosin are present in mammalian skeletal muscles. The diversity of the heavy-chain subunits of myosin (MyHCs) in intrafusal fibers is thought to reflect a pathway of differentiation that is unique to muscle spindles. In fact, intrafusal MyHCs are developmental isoforms expressed by the prenatal precursors of both intrafusal and extrafusal fibers. In adult limbs, developmental MyHCs persist in intrafusal, but not extrafusal fibers principally due to the afferent neurons that arrest their maturational replacement by MyHCs associated with faster shortening velocities. The slow shortening velocities that are characteristic of developmental MyHCs might be adaptive for precise calibration of muscle spindles as sense organs. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/s0166-2236(98)01339-3" target="_blank" rel="noreferrer noopener">10.1016/s0166-2236(98)01339-3</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Muscle Development 1999 Afferent Pathways/physiology Aging/metabolism Animals Cell Lineage Developmental Fetal Proteins/metabolism Gene Expression Regulation Knockout Kucera J Mammals/anatomy & histology/*metabolism Mice Morphogenesis Muscle Muscle Contraction Muscle Fibers Muscle Proteins/deficiency/physiology Muscle Spindles/physiology Myosin Heavy Chains/*metabolism Nerve Tissue Proteins/deficiency/physiology Protein Isoforms/*metabolism Rats Skeletal/*chemistry/classification Skeletal/chemistry/embryology/*growth & development/ultrastructure Transgenic Trends in neurosciences Walro J M