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40
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Text
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n/a
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Pages
9272-9276
Issue
24
Volume
20
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Title
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Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory
Publisher
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Journal of Neuroscience
Date
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2000
2000-12
Subject
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hippocampus; rat; learning; verapamil; Neurosciences & Neurology; expression; neurons; long-term potentiation; environment; NMDA; MK-801; 2 forms; voltage-dependent calcium channel; nmdaLTP; spatial memory; vdccLTP; antagonist mk-801; working
Creator
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Borroni A M; Fichtenholtz H; Woodside B L; Teyler T J
Description
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This experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in rats learning an eight-arm radial maze task. Animals were trained twice a day for 11 d under the systemic influence of MK-801, verapamil, both drugs, or saline. During acquisition, the mixed drug group displayed significantly more working memory errors and reference memory errors than all other groups. The mixed drug group was markedly impaired on the first daily trial but improved dramatically on their second daily trial. After a 7 d delay, saline and MK-801 animals maintained their predelay level of performance. The performance of the verapamil groups declined significantly over the delay. These results demonstrate that: (1) vdccLTP is necessary for the retention of information over a 7 dperiod, (2) the blockade of both forms of LTP prevents the retention of information over a 21 hr period, and (3) blockade of both forms of LTP does not prevent the storing of information over a short period of time (3 hr).
Identifier
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n/a
Format
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Journal Article or Conference Abstract Publication
2 forms
2000
antagonist mk-801
Borroni A M
Environment
expression
Fichtenholtz H
Hippocampus
Journal Article or Conference Abstract Publication
Journal of Neuroscience
Learning
Long-Term Potentiation
MK-801
Neurons
Neurosciences & Neurology
NMDA
nmdaLTP
rat
spatial memory
Teyler T J
vdccLTP
verapamil
voltage-dependent calcium channel
Woodside B L
Working