1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.bbr.2019.112456" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bbr.2019.112456</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 112456 Volume 381 ISSN 1872-7549 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.bbr.2019.112456" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.bbr.2019.112456</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number January 2020 Update NEOMED College NEOMED College of Pharmacy NEOMED Department Department of Pharmaceutical Sciences Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Sex differences in cognitive performance and alcohol consumption in High Alcohol-Drinking (HAD-1) rats Publisher An entity responsible for making the resource available Behavioural Brain Research Date A point or period of time associated with an event in the lifecycle of the resource 2019 2019-12-28 Subject The topic of the resource Alcohol use disorders; Attention; Exploratory behavior; Novel object recognition; Object recognition test; Selectively bred high alcohol-drinking rats Creator An entity primarily responsible for making the resource Mittal N; Fleming S M; Martinez A; Thakore N; Bell R L; Maddox W T; Schallert T; Duvauchelle C L Description An account of the resource Excessive alcohol (ethanol) consumption negatively impacts social, emotional, as well as cognitive function and well-being. Thus, identifying behavioral and/or biological predictors of excessive ethanol consumption is important for developing prevention and treatment strategies against alcohol use disorders (AUDs). Sex differences in alcohol consumption patterns are observed in humans, primates, and rodents. Selectively bred high alcohol-drinking rat lines, such as the "HAD-1" lines are recognized animal models of alcoholism. The present work examined sex differences in alcohol consumption, object recognition, and exploratory behavior in male and female HAD-1 rats. Naïve male and female HAD-1 rats were tested in an object recognition test (ORT) prior to a chronic 24 h intermittent ethanol access procedure for five weeks. Object recognition parameters measured included exploratory behavior, object investigation, and time spent near objects. During the initial training trial, rearing, active object investigation and amount of time spent in the object-containing section was significantly greater in female HAD-1 rats compared to their male counterparts. During the subsequent testing trial, time spent in the object-containing section was greater in female, compared to male, rats; but active object investigation and rearing did not statistically differ between females and males. In addition, female HAD-1 rats consumed significantly more ethanol than their male counterparts, replicating previous findings. Moreover, across all animals there was a significant positive correlation between exploratory behavior in ORT and ethanol consumption level. These results indicate there are significant sex differences in cognitive performance and alcohol consumption in HAD-1 rats, which suggests neurobiological differences as well. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.bbr.2019.112456" target="_blank" rel="noreferrer noopener">10.1016/j.bbr.2019.112456</a> PMID: 31891743 Format The file format, physical medium, or dimensions of the resource Journal Article 2019 Alcohol use disorders Attention Behavioural brain research Bell R L Department of Pharmaceutical Sciences Duvauchelle C L Exploratory behavior Fleming S M January 2020 Update Journal Article Maddox W T Martinez A Mittal N NEOMED College of Pharmacy Novel object recognition Object recognition test Schallert T Selectively bred high alcohol-drinking rats Thakore N