1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s12011-019-01964-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s12011-019-01964-4</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1559-0720
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s12011-019-01964-4" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s12011-019-01964-4</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Fluoride-Free Diet Stimulates Pineal Growth in Aged Male Rats
Publisher
An entity responsible for making the resource available
Biological Trace Element Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-11-12
Subject
The topic of the resource
Aging; Calcification; Melatonin; Drinking water; Fluoridation; Fluoride; Neurodegenerative disease; Pineal gland; Pinealocytes
Creator
An entity primarily responsible for making the resource
Mrvelj Aaron; Womble Mark D
Description
An account of the resource
The pineal gland is a naturally calcifying endocrine organ which secretes the sleep-promoting hormone melatonin. Age-related changes of the pineal have been observed, including decreased pinealocyte numbers, increased calcification, and a reduction in melatonin production. Since fluoride is attracted to calcium within the pineal gland, this study sought to examine the effects of a fluoride-free diet on the morphology of the pineal gland of aged male rats (26 months old). All animals had previously been raised on standard fluoridated food and drinking water. These control animals were compared to other animals that were placed on a fluoride-free diet ("fluoride flush") for 4 or 8 weeks. At 4 weeks, pineal glands from fluoride-free animals showed a 96% increase in supporting cell numbers and at 8 weeks a 73% increase in the number of pinealocytes compared to control animals. In contrast, the number of pinealocytes and supporting cells in animals given an initial 4-week fluoride flush followed by a return to fluoridated drinking water (1.2 ppm NaF) for 4 weeks were not different from control animals. Our findings therefore demonstrate that a fluoride-free diet encouraged pinealocyte proliferation and pineal gland growth in aged animals and fluoride treatment inhibited gland growth. These findings suggest that dietary fluoride may be detrimental to the pineal gland.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s12011-019-01964-4" target="_blank" rel="noreferrer noopener">10.1007/s12011-019-01964-4</a>
PMID: 31713773
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Aging
Biological Trace Element Research
Calcification
Department of Anatomy & Neurobiology
drinking water
Fluoridation
Fluoride
Journal Article
Melatonin
Mrvelj Aaron
NEOMED College of Medicine
neurodegenerative disease
November 2019 Update
Pineal gland
Pinealocytes
Womble Mark D