1
40
4
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Text
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URL Address
<a href="http://doi.org/10.1007/s00467-018-4061-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00467-018-4061-9</a>
Dublin Core
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Title
A name given to the resource
An update on LDL apheresis for nephrotic syndrome.
Publisher
An entity responsible for making the resource available
Pediatric nephrology (Berlin, Germany)
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-09
Subject
The topic of the resource
Focal segmental glomerulosclerosis; Hyperlipidemia; Liposorber(R) LA-15 System; Low-density lipoprotein apheresis; Nephrotic syndrome; Podocyte injury
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Krishnappa Vinod
Description
An account of the resource
Low-density lipoprotein (LDL) apheresis has been used increasingly in clinical practice for the treatment of renal diseases with nephrotic syndrome (NS), specifically focal segmental glomerulosclerosis (FSGS). Persistent hyperlipidemia for prolonged periods is nephrotoxic and leads to chronic progressive glomerular and tubulointerstitial injury. Effective management of hyperlipidemia with
Identifier
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<a href="http://doi.org/10.1007/s00467-018-4061-9" target="_blank" rel="noreferrer noopener">10.1007/s00467-018-4061-9</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Department of Internal Medicine
Focal segmental glomerulosclerosis
Hyperlipidemia
Krishnappa Vinod
Liposorber(R) LA-15 System
Low-density lipoprotein apheresis
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
Nephrotic syndrome
Pediatric nephrology (Berlin, Germany)
Podocyte injury
Raina Rupesh
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fped.2019.00454</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
454
Volume
7
ISSN
2296-2360
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3389/fped.2019.00454</a>
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Update Year & Number
January 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Affiliated Hospital
Cleveland Clinic Akron General
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dextran-Sulfate Plasma Adsorption Lipoprotein Apheresis in Drug Resistant Primary Focal Segmental Glomerulosclerosis Patients: Results From a Prospective, Multicenter, Single-Arm Intervention Study
Publisher
An entity responsible for making the resource available
Frontiers in Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
1905-07
Subject
The topic of the resource
focal segmental glomerulosclerosis; lipoprotein apheresis; liposorber; nephrotic syndrome; proteinuria
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Krishnappa Vinod; Sanchez-Kazi Cheryl; Quiroga Alejandro; Twombley Katherine E; Mathias Robert; Lo Megan; Chakraborty Ronith; Mahesh Shefali; Steinke Julia; Bunchman Timothy; Zaritsky Joshua
Description
An account of the resource
Background: Focal segmental glomerulosclerosis (FSGS) causes end stage renal disease (ESRD) in significant proportion of patients worldwide. Primary FSGS carries poor prognosis and management of FSGS patients, refractory to standard treatments or resistant to steroids, remains a major challenge. Lipoprotein apheresis is a therapeutic approach for drug resistant primary FSGS and post-renal transplant primary FSGS recurrence. Objectives: To examine the safety and probable benefit at 1, 3, 6, 12, and 24-months following completion of apheresis treatment using Liposorber® LA-15 system in patients with nephrotic syndrome (NS), due to refractory primary FSGS or primary FSGS associated NS, in post renal transplant children. Material and Methods: Prospective, multicenter, single-arm intervention study using Liposorber® LA-15 system. Patients ≤21 years old with drug resistant or drug intolerant NS secondary to primary FSGS with glomerular filtration rate (GFR) ≥60 ml/min/1.73 m2 or post renal transplant patients ≤21 years old with primary FSGS associated NS were included in the study. Each patient had 12 dextran-sulfate plasma adsorption lipoprotein apheresis sessions over a period of 9 weeks. All patients were followed up at 1, 3, 6, 12, and 24-months following completion of treatment. Results: Of 17 patients enrolled, six were excluded from the outcome analysis (protocol deviations). Of the remaining 11 patients, all but one have completed apheresis treatments. Three patients were lost to follow-up immediately after completion of apheresis and excluded from outcome analysis. At one-month follow-up, 1 of 7 patients (14.3%) attained partial remission of NS while 2 of 4 subjects (50%) and 2 of 3 subjects (66.7%) had partial/complete remission at 3- and 6-months follow-up, respectively. One of two patients followed up for 12 months had complete remission and one patient had partial remission of NS after 24 months. Improved or stable eGFR was noted in all patients over the follow-up period. Conclusion: The results of our multicenter study showed improvement in the response rates to steroid or immunosuppressive therapy and induced complete or partial remission of proteinuria in some of the patients with drug resistant primary FSGS. The main limitation of our study is the small number of subjects and high dropout rate.
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<a href="http://doi.org/10.3389/fped.2019.00454" target="_blank" rel="noreferrer noopener">10.3389/fped.2019.00454</a>
PMID: 31850285 PMCID: PMC6902874
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Bunchman Timothy
Chakraborty Ronith
Focal segmental glomerulosclerosis
Frontiers in pediatrics
January 2020 Update
Journal Article
Krishnappa Vinod
Lipoprotein apheresis
liposorber
Lo Megan
Mahesh Shefali
Mathias Robert
NEOMED College of Graduate Studies Student
NEOMED Student Publications
Nephrotic syndrome
Proteinuria
Quiroga Alejandro
Raina Rupesh
Sanchez-Kazi Cheryl
Steinke Julia
Twombley Katherine E
Zaritsky Joshua
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000506277" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000506277</a>
Pages
1-11
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1159/000506277" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1159/000506277</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Graduate Studies
NEOMED Department
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Extracorporeal Therapies in the Treatment of Focal Segmental Glomerulosclerosis.
Publisher
An entity responsible for making the resource available
Blood purification
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-02
Subject
The topic of the resource
Focal segmental glomerulosclerosis; Low-density lipoprotein apheresis; Extracorporeal therapy; Immunoadsorption; Plasma exchange
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Wang Joseph; Sharma Aditya; Chakraborty Ronith
Description
An account of the resource
Focal segmental glomerulosclerosis (FSGS) is one of the most frequent and severe glomerular kidney disease with frequent progression to end-stage renal disease and a high rate of recurrence in renal transplantations. Due to intolerance or resistance to the current immunomodulatory treatments, the management of FSGS is a therapeutic challenge. Over the last few years, development in extracorporeal therapies has shown potential beneficial outcomes in drug-resistant and recurrent FSGS patients. Thus, this study reviews the current literature on the use of extracorporeal therapies, such as plasma exchange therapy, immunoadsorption, and low-density lipoprotein apheresis, for the treatment of FSGS in the pediatric population.
Identifier
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<a href="http://doi.org/10.1159/000506277" target="_blank" rel="noreferrer noopener">10.1159/000506277</a>
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Journal Article
2020
Blood purification
Chakraborty Ronith
Extracorporeal therapy
Focal segmental glomerulosclerosis
Immunoadsorption
Low-density lipoprotein apheresis
NEOMED College of Graduate Studies
NEOMED College of Graduate Studies Student
Plasma exchange
Raina Rupesh
Sharma Aditya
Wang Joseph
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000504623" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000504623</a>
Pages
22-34
Issue
1
Volume
6
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Graduate Studies; NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.
Publisher
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Kidney diseases (Basel, Switzerland)
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-01
Subject
The topic of the resource
Focal segmental glomerulosclerosis; Diabetic nephropathy; Endothelin; Endothelin antagonists; Hypertensive nephropathy
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Chauvin Abigail; Chakraborty Ronith; Nair Nikhil; Shah Haikoo; Krishnappa Vinod; Kusumi Kirsten
Description
An account of the resource
Background: Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling pathways tied to regulation of aldosterone, catecholamines, and angiotensin. In the kidney, ET-1 is critical to maintaining renal perfusion and controls glomerular arteriole tone and hemodynamics. It is hypothesized that
Identifier
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<a href="http://doi.org/10.1159/000504623" target="_blank" rel="noreferrer noopener">10.1159/000504623</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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Journal Article
2020
Chakraborty Ronith
Chauvin Abigail
Diabetic nephropathy
Endothelin
Endothelin antagonists
Focal segmental glomerulosclerosis
Hypertensive nephropathy
Kidney diseases (Basel
Kidney diseases (Basel, Switzerland)
Krishnappa Vinod
Kusumi Kirsten
Nair Nikhil
NEOMED College of Graduate Studies Student
NEOMED College of Medicine Student
NEOMED Student Publications
Raina Rupesh
Shah Haikoo
Switzerland)