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Text
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URL Address
<a href="http://doi.org/10.1016/s0014-2999(97)01351-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0014-2999(97)01351-4</a>
Pages
17–26
Issue
1
Volume
340
Dublin Core
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Title
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Olanzapine attenuates the reinforcing effects of cocaine.
Publisher
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European journal of pharmacology
Date
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1997
1997-12
Subject
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Animal/*drug effects; Animals; Antipsychotic Agents/administration & dosage/*pharmacology; Behavior; Benzodiazepines; Cocaine/administration & dosage/antagonists & inhibitors/*pharmacology; Conditioning; Dopamine Uptake Inhibitors/administration & dosage/*pharmacology; Dose-Response Relationship; Drug; Food Preferences/drug effects; Male; Olanzapine; Operant/*drug effects; Pirenzepine/administration & dosage/*analogs & derivatives/pharmacology; Rats; Self Administration; Sprague-Dawley
Creator
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Meil W M; Schechter M D
Description
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The possibility that the atypical neuroleptic olanzapine can antagonize the ability of cocaine to produce both conditioned place preference and self-administration in rats was investigated. Pre-treatment with olanzapine (3.0, 4.5 mg/kg, but not 1.5 mg/kg) significantly attenuated conditioned place preference produced by cocaine (10 mg/kg). However, the higher dose of olanzapine administered alone resulted in conditioned place aversion. Pre-treatment with olanzapine also produced a dose-dependent decrease in cocaine self-administration (0.33 mg/infusion) under a fixed-ratio 2 schedule of reinforcement. Olanzapine produced a similar dose-responsive attenuation in operant responding for food (fixed-ratio 10) suggesting that olanzapine produces a nonspecific decrease in operant behavior. Pre-treatment with 4.5 mg/kg olanzapine significantly attenuated cocaine-induced hyperactivity, whereas lower olanzapine doses had little effect upon cocaine-induced hyperactivity. These results suggest that pre-treatment with olanzapine is capable of blocking the reinforcing effects of cocaine and illustrates the value of using multiple tests of reinforcement when evaluating the pharmacological effects of newer psychotherapeutic agents.
Identifier
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<a href="http://doi.org/10.1016/s0014-2999(97)01351-4" target="_blank" rel="noreferrer noopener">10.1016/s0014-2999(97)01351-4</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Animal/*drug effects
Animals
Antipsychotic Agents/administration & dosage/*pharmacology
Behavior
Benzodiazepines
Cocaine/administration & dosage/antagonists & inhibitors/*pharmacology
Conditioning
Dopamine Uptake Inhibitors/administration & dosage/*pharmacology
Dose-Response Relationship
Drug
European journal of pharmacology
Food Preferences/drug effects
Male
Meil W M
Olanzapine
Operant/*drug effects
Pirenzepine/administration & dosage/*analogs & derivatives/pharmacology
Rats
Schechter M D
Self Administration
Sprague-Dawley