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40
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Text
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<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofy351</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
N.PAG-N.PAG
Issue
1
Volume
6
ISSN
23288957
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/ofid/ofy351</a>
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Title
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Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.
Publisher
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Open Forum Infectious Diseases
Date
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2019
2019-01
Subject
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antimicrobial resistance; carbapenem-resistant enterobacteriaceae; Klebsiella pneumonia; trimethoprim-sulfamethoxazole; urinary tract infection
Creator
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Luterbach Courtney L; Boshe Ashley; Henderson Heather I; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Hujer Andrea M; Hujer Kristine M; Rudin Susan D; Domitrovic T Nicholas; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G; Bonomo Robert A; Duin David van
Description
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In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.1093/ofid/ofy351" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofy351</a>
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Journal Article
2019
Antimicrobial resistance
Bonomo Robert A
Boshe Ashley
carbapenem-resistant Enterobacteriaceae
Clev eland Clinic Akron General Hosptial
Cober Eric
Department of Internal Medicine
Doi Yohei
Domitrovic T Nicholas
Duin David van
Evans Scott
Fowler Vance G
Henderson Heather I
Hujer Andrea M
Hujer Kristine M
Journal Article
Kalayjian Robert C
Kaye Keith S
Klebsiella pneumonia
Luterbach Courtney L
NEOMED College of Medicine
November 2019 Update
Open forum infectious diseases
Richter Sandra S
Rudin Susan D
Salata Robert A
trimethoprim-sulfamethoxazole
urinary tract infection
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/cid/ciz528" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/cid/ciz528</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The Pitt Bacteremia Score Predicts Mortality in Non-Bacteremic Infections.
Publisher
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Clinical Infectious Diseases: An Official Publication Of The Infectious Diseases Society Of America
Date
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2019
2019-06
Creator
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Henderson Heather; Luterbach Courtney L; Cober Eric; Richter Sandra S; Salata Robert A; Kalayjian Robert C; Watkins Richard R; Doi Yohei; Kaye Keith S; Evans Scott; Fowler Vance G; Bonomo Robert A; Harris Anthony; Napravnik Sonia; van Duin David
Description
An account of the resource
Background: Predicting mortality risk in patients is important in research settings. The Pitt bacteremia score (PBS) is commonly used as a predictor of early mortality risk in patients with bloodstream infections (BSI). Here, we determined whether the PBS predicts 14-day inpatient mortality in non-bacteremia carbapenem-resistant Enterobacteriaceae (CRE) infections.; Methods: Patients were selected from the Consortium on resistance against carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE-1), a prospective, multicenter, observational study. We estimated risk ratios to analyze the predictive ability of the PBS overall and each of its components individually. We analyzed each component of the PBS in the prediction of mortality, assessed the appropriate cutoff value for the dichotomized score, and compared the predictive ability of the qPitt score to that of the PBS.; Results: In a cohort of 475 patients with CRE infections, a PBS ≥ 4 was associated with mortality in patients with non-bacteremia infections (RR=21.9 [95% CI: 7.0, 68.8]) and with BSI (RR=6.0 [95% CI: 2.5, 14.4]). In multivariable analysis, the hypotension, mechanical ventilation, mental status, and cardiac arrest parameters of the PBS were independent risk factors for 14-day all-cause inpatient mortality. The temperature parameter as originally calculated for the PBS was not independently associated with mortality. However, a temperature < 36.0ᴼ C versus ≥ 36ᴼ C was independently associated with mortality. A qPitt score ≥ 2 had similar discrimination as a PBS ≥ 4 in non-bacteremia infections.; Conclusion: Here, we validated that the PBS and qPitt score can be used as reliable predictors of mortality in non-bacteremia CRE infections.; © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Identifier
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<a href="http://doi.org/10.1093/cid/ciz528" target="_blank" rel="noreferrer noopener">10.1093/cid/ciz528</a>
2019
Bonomo Robert A
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Cober Eric
Department of Family & Community Medicine
Department of Internal Medicine
Doi Yohei
Evans Scott
Fowler Vance G
Harris Anthony
Henderson Heather
Kalayjian Robert C
Kaye Keith S
Luterbach Courtney L
Napravnik Sonia
NEOMED College of Medicine
Richter Sandra S
Salata Robert A
September 2019 Update
van Duin David
Watkins Richard R