Browse Items (10 total)
- Tags: Free radical biology & medicine
Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells.
Tags: 2011, Aorta/pathology, Apoptosis/drug effects, Atherosclerosis/*drug therapy/metabolism/pathology/physiopathology, Brasch Nicola E, Cell Line, Cell Survival/drug effects, Cytoprotection, Department of Integrative Medical Sciences, Endothelium, Free radical biology & medicine, Free Radical Scavengers/*pharmacology, Humans, Mitochondria/drug effects/metabolism/pathology, Moreira Edward S, NEOMED College of Medicine, Oxidative Stress/drug effects, Reperfusion Injury/*drug therapy/metabolism/pathology/physiopathology, Superoxides/metabolism, Vascular/*drug effects/metabolism/pathology, Vitamin B 12/*pharmacology, Vitamin B Complex/*pharmacology, Yun June
Protein thiyl radical mediates S-glutathionylation of complex I.
Tags: *Oxidative Stress, 2012, Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Cattle, Cell Line, Chen Chwen-Lih, Chen Jingfeng, Chen Yeong-Renn, Cyclic N-Oxides/chemistry/pharmacology, Cysteine/chemistry/*metabolism, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Free radical biology & medicine, Free Radical Scavengers/chemistry/pharmacology, Free Radicals/chemistry/*metabolism, Glutathione/chemistry/*metabolism, Green Kari B, Heart/enzymology/metabolism, Kang Patrick T, Mice, Mitochondria, Models, Molecular, Molecular Sequence Data, Muscle Cells/drug effects/metabolism, NEOMED College of Medicine, Onium Compounds/pharmacology, Peptide Fragments/chemistry, Peptide Mapping, Protein, Rats, Rotenone/pharmacology, Structural Homology, Superoxides/metabolism, Zhang Liwen
Increased mitochondrial prooxidant activity mediates up-regulation of Complex I
Tags: *Up-Regulation, 2015, Animals, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Spin Resonance Spectroscopy, eNOS(-/-) murine heart, Free radical biology & medicine, Glutathione/*metabolism, Heart/*metabolism, Kang Patrick T, Knockout, Mice, Mitochondria, Myocardium/enzymology/*metabolism, NEOMED College of Medicine, Nitric Oxide Synthase Type III/genetics/*metabolism, Oxidation-Reduction, Oxidative Stress, Protein thiyl radical, Reactive Oxygen Species/*metabolism, S-Glutathionylation, Superoxides/metabolism
A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.
Tags: *Flux, *Glutathione, *Heavy water, *Mass spectrometer, *NAFLD, *NASH, *Oxidative Stress, *Western Diet, 2016, Animal, Animals, Antioxidants/metabolism, Department of Pharmaceutical Sciences, Diet, Disease Models, Free radical biology & medicine, Glutathione/blood/*metabolism, Humans, Kasumov Takhar, LDL/blood/*genetics/metabolism, Lee Kwangwon, Li Ling, Liver/*metabolism/pathology, Lopez Rocio, McCullough Arthur, Mice, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/blood/*genetics/pathology, Oxidative Stress/genetics, Previs Stephen F, Receptors, Western/adverse effects, Willard Belinda, Zhang Guo-Fang
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.
Tags: *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, *Wogonin, 2017, Ansari Mohammad Y, Anti-Inflammatory Agents/administration & dosage, Chondrocytes/drug effects/pathology, Department of Anatomy & Neurobiology, Devarapalli Pratap, Flavanones/*administration & dosage, Free radical biology & medicine, Gene Expression Regulation/drug effects, Haqqi Tariq M, Haseeb Abdul, Haynie Sara, Humans, Inflammation/*drug therapy/metabolism/pathology, Kelch-Like ECH-Associated Protein 1/chemistry/*genetics/metabolism, Khan Nazir M, MAP Kinase Signaling System/drug effects, Molecular Docking Simulation, NEOMED College of Medicine, NF-E2-Related Factor 2/antagonists & inhibitors/chemistry/*genetics/metabolism, Osteoarthritis/*drug therapy/metabolism/pathology, Protein Binding, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects
Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine
Tags: *Cardiac-specific transgenic mouse, *Mitochondria, *Mitochondrial translocation, *Protein acetylation, *Protein aggregation, *SOD2, 2017, Acetylation, Animals, Cardiomegaly/*metabolism, Chen Chwen-Lih, Chen Yeong-Renn, Cytosol/*metabolism, Department of Integrative Medical Sciences, Free radical biology & medicine, Heart/*physiology, Jin Zhicheng, Kang Patrick T, Mice, Mitochondria/*metabolism, NEOMED College of Medicine, Pathological, Post-Translational, Protein Aggregation, Protein Folding, Protein Processing, Protein Transport, Reactive Oxygen Species/metabolism, Sirtuin 3/metabolism, Superoxide Dismutase/genetics/*metabolism, Transgenic, Zhang Liwen
Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.
Tags: *Ceruloplasmin, *Deamidation, *Heavy water metabolic labeling, *High resolution mass spectrometry, *Iron metabolism, *LC-MS/MS, *Non-enzymatic glycation, *Oxidative Stress, *Protein Processing, *Proteome dynamics, *Serotransferrin, *Type 2 diabetes mellitus, 2017, Adult, Amino Acid Sequence, Bena James, Case-Control Studies, Ceruloplasmin/genetics/*metabolism, Department of Pharmaceutical Sciences, Deuterium/metabolism, Diabetes Mellitus, Diabetic, Diet, Female, Free radical biology & medicine, Gene Expression Regulation, Glycated Hemoglobin A/genetics/metabolism, Glycosylation, Golizeh Makan, Humans, Ilchenko Serguei, Iron/*metabolism, Isotope Labeling, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Male, Middle Aged, NEOMED College of Pharmacy, Osme Abdullah, Oxidation-Reduction, Oxidative Stress, Post-Translational, Proteolysis, Sadygov Rovshan G, Transferrin/genetics/*metabolism, Type 2/diet therapy/genetics/*metabolism/pathology
Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.
Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.
Tags: *Apoptosis, *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, 2018, 70-kDa/metabolism, 90-kDa/metabolism, Ahmad Imran, Carboxylic Ester Hydrolases/metabolism, Caspases/metabolism, Cells, Chondrocytes/*physiology, Cultured, ets-Domain Protein Elk-1/metabolism, Free radical biology & medicine, Haqqi Tariq M, Humans, Interleukin-1beta/immunology, Khan Nazir M, MAP Kinase Signaling System, NF-E2-Related Factor 2/genetics/*metabolism, Osteoarthritis/*metabolism, Oxidative Stress, Ribosomal Protein S6 Kinases, Up-Regulation