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Text
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URL Address
<a href="http://doi.org/10.1128/JVI.02210-10" target="_blank" rel="noreferrer noopener">http://doi.org/10.1128/JVI.02210-10</a>
Pages
2060–2078
Issue
5
Volume
85
Dublin Core
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Title
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Retrovirus-induced spongiform neurodegeneration is mediated by unique central nervous system viral targeting and expression of env alone.
Publisher
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Journal of virology
Date
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2011
2011-03
Subject
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Animals; Cell Line; Friend murine leukemia virus/genetics/metabolism; Humans; Leukemia Virus; Mice; Murine/genetics/*metabolism/pathogenicity; Nerve Degeneration; Neural Stem Cells/pathology/virology; Neurodegenerative Diseases/pathology/*virology; Retroviridae Infections/pathology/*virology; Viral Envelope Proteins/genetics/*metabolism; Virulence
Creator
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Li Ying; Cardona Sandra M; Traister Russell S; Lynch William P
Description
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Certain murine leukemia viruses (MLVs) can induce progressive noninflammatory spongiform neurodegeneration similar to that caused by prions. The primary MLV determinants responsible have been mapped to within the env gene; however, it has remained unclear how env mediates disease, whether non-Env viral components are required, and what central nervous system (CNS) cells constitute the critical CNS targets. To address these questions, we examined the effect of transplanting engraftable C17.2 neural stem cells engineered to pseudotype, disseminate, and trans-complement neurovirulent (CasBrE, CasE, and CasES) or non-neurovirulent (Friend and SFF-FE) env sequences (SU or SU/TM) within the CNS using either the "non-neurovirulent" amphotropic helper virus, 4070A, or pgag-polgpt (a nonpackaged vector encoding Gag-Pol). These studies revealed that acute
Identifier
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<a href="http://doi.org/10.1128/JVI.02210-10" target="_blank" rel="noreferrer noopener">10.1128/JVI.02210-10</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Cardona Sandra M
Cell Line
Department of Integrative Medical Sciences
Friend murine leukemia virus/genetics/metabolism
Humans
Journal of virology
Leukemia Virus
Li Ying
Lynch William P
Mice
Murine/genetics/*metabolism/pathogenicity
NEOMED College of Medicine
Nerve Degeneration
Neural Stem Cells/pathology/virology
Neurodegenerative Diseases/pathology/*virology
Retroviridae Infections/pathology/*virology
Traister Russell S
Viral Envelope Proteins/genetics/*metabolism
Virulence