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<a href="http://doi.org/10.1038/s41467-021-23129-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/s41467-021-23129-5</a>
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2652
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1
Volume
12
ISSN
2041-1723
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1038/s41467-021-23129-5" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1038/s41467-021-23129-5</a>
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NEOMED College of Medicine
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Department of Anatomy & Neurobiology
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Author Correction: DNA methylation predicts age and provides insight into exceptional longevity of bats.
Publisher
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Nature Communications
Date
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2021
2021-05-05
Creator
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Wilkinson GS; Adams DM; Haghani A; Lu AT; Zoller J; Breeze CE; Arnold BD; Ball HC; Carter GG; Cooper LN; Dechmann DKN; Devanna P; Fasel NJ; Galazyuk AV; Günther L; Hurme E; Jones G; Knörnschild M; Lattenkamp EZ; Li CZ; Mayer F; Reinhardt JA; Medellin RA; Nagy M; Pope B; Power ML; Ransome RD; Teeling EC; Vernes SC; Zamora-Mejías D; Zhang J; Faure PA; Greville LJ; Horvath S; Herrera MLG; Flores-Martínez JJ
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<a href="http://doi.org/10.1038/s41467-021-23129-5" target="_blank" rel="noreferrer noopener">10.1038/s41467-021-23129-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2021
Adams DM
Arnold BD
Ball HC
Breeze CE
Carter GG
Cooper LN
Dechmann DKN
Department of Anatomy & Neurobiology
Devanna P
Fasel NJ
Faure PA
Flores-Martínez JJ
Galazyuk AV
Greville LJ
Günther L
Haghani A
Herrera MLG
Horvath S
Hurme E
Jones G
journalArticle
Knörnschild M
Lattenkamp EZ
Li CZ
Lu AT
May 2021 List
Mayer F
Medellin RA
Nagy M
Nature communications
NEOMED College of Medicine
NEOMED Postdoc Publications
Pope B
Power ML
Ransome RD
Reinhardt JA
Teeling EC
Vernes SC
Wilkinson GS
Zamora-Mejías D
Zhang J
Zoller J
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/10.1038/s41467-021-21900-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/s41467-021-21900-2</a>
Pages
1615
Issue
1
Volume
12
ISSN
2041-1723
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Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1038/s41467-021-21900-2" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1038/s41467-021-21900-2</a>
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Update Year & Number
April 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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DNA methylation predicts age and provides insight into exceptional longevity of bats.
Publisher
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Nature Communications
Date
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2021
2021-03-12
Subject
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DNA Methylation; Aging/genetics; Animals; Carcinogenesis/genetics; Chiroptera/genetics; Chromatin; Epigenesis Genetic; Genetic Techniques; Histones; Immunity Innate/genetics; Longevity/genetics; Phylogeny
Creator
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Wilkinson GS; Adams DM; Haghani A; Lu AT; Zoller J; Breeze CE; Arnold BD; Ball HC; Carter GG; Cooper LN; Dechmann DKN; Devanna P; Fasel NJ; Galazyuk AV; Günther L; Hurme E; Jones G; Knörnschild M; Lattenkamp EZ; Li CZ; Mayer F; Reinhardt JA; Medellin RA; Nagy M; Pope B; Power ML; Ransome RD; Teeling EC; Vernes Sonja C; Zamora-Mejías D; Zhang J; Faure PA; Greville LJ; Horvath S
Description
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Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species, to identify epigenetic changes associated with age and longevity. We demonstrate that DNAm accurately predicts chronological age. Across species, longevity is negatively associated with the rate of DNAm change at age-associated sites. Furthermore, analysis of several bat genomes reveals that hypermethylated age- and longevity-associated sites are disproportionately located in promoter regions of key transcription factors (TF) and enriched for histone and chromatin features associated with transcriptional regulation. Predicted TF binding site motifs and enrichment analyses indicate that age-related methylation change is influenced by developmental processes, while longevity-related DNAm change is associated with innate immunity or tumorigenesis genes, suggesting that bat longevity results from augmented immune response and cancer suppression.
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<a href="http://doi.org/10.1038/s41467-021-21900-2" target="_blank" rel="noreferrer noopener">10.1038/s41467-021-21900-2</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2021
Adams DM
Aging/genetics
Animals
April 2021 List
Arnold BD
Ball HC
Breeze CE
Carcinogenesis/genetics
Carter GG
Chiroptera/genetics
Chromatin
Cooper LN
Dechmann DKN
Department of Anatomy & Neurobiology
Devanna P
DNA Methylation
Epigenesis Genetic
Fasel NJ
Faure PA
Galazyuk AV
Genetic Techniques
Greville LJ
Günther L
Haghani A
Histones
Horvath S
Hurme E
Immunity Innate/genetics
Jones G
journalArticle
Knörnschild M
Lattenkamp EZ
Li CZ
Longevity/genetics
Lu AT
Mayer F
Medellin RA
Nagy M
Nature communications
NEOMED College of Medicine
Phylogeny
Pope B
Power ML
Ransome RD
Reinhardt JA
Teeling EC
Vernes Sonja C
Wilkinson GS
Zamora-Mejías D
Zhang J
Zoller J