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Text
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URL Address
<a href="http://doi.org/10.1016/0165-3806(94)90206-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-3806(94)90206-2</a>
Pages
295–298
Issue
2
Volume
77
Dublin Core
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Title
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The development of GABAB-mediated activity in the rat dentate gyrus.
Publisher
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Brain research. Developmental brain research
Date
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1994
1994-02
Subject
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Animals; Baclofen/analogs & derivatives/pharmacology; Electric Stimulation; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/physiology; GABA-B Receptor Antagonists; GABA-B/*metabolism; Hippocampus/*growth & development/*metabolism; In Vitro Techniques; Organophosphorus Compounds/pharmacology; Rats; Receptors
Creator
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DiScenna P G; Nowicky A V; Teyler T J
Description
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We examined the effects of GABAB receptor activation in the dentate gyrus of hippocampal slices prepared from 6-8-day-old rat pup. Baclofen (0.25-1.0 microM), a GABAB agonist, rapidly and potently disinhibited the developing dentate, similar to its effect in the mature organism. CGP 35348, a GABAB antagonist, quickly reversed the baclofen-induced disinhibition. However, GABAB antagonists did not reverse long-latency (500-1000 ms IPI) paired-pulse depression, suggesting that it is not caused by a late GABAB-mediated IPSP. GABAB-mediated disinhibition of the dentate gyrus can occur by postnatal day 6, providing a powerful mechanism for altering excitability in the developing hippocampus.
Identifier
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<a href="http://doi.org/10.1016/0165-3806(94)90206-2" target="_blank" rel="noreferrer noopener">10.1016/0165-3806(94)90206-2</a>
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1994
Animals
Baclofen/analogs & derivatives/pharmacology
Brain research. Developmental brain research
DiScenna P G
Electric Stimulation
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
GABA-A/drug effects/physiology
GABA-B Receptor Antagonists
GABA-B/*metabolism
Hippocampus/*growth & development/*metabolism
In Vitro Techniques
Nowicky A V
Organophosphorus Compounds/pharmacology
Rats
Receptors
Teyler T J