1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-3806(94)90206-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-3806(94)90206-2</a>
Pages
295–298
Issue
2
Volume
77
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The development of GABAB-mediated activity in the rat dentate gyrus.
Publisher
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Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-02
Subject
The topic of the resource
Animals; Baclofen/analogs & derivatives/pharmacology; Electric Stimulation; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/physiology; GABA-B Receptor Antagonists; GABA-B/*metabolism; Hippocampus/*growth & development/*metabolism; In Vitro Techniques; Organophosphorus Compounds/pharmacology; Rats; Receptors
Creator
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DiScenna P G; Nowicky A V; Teyler T J
Description
An account of the resource
We examined the effects of GABAB receptor activation in the dentate gyrus of hippocampal slices prepared from 6-8-day-old rat pup. Baclofen (0.25-1.0 microM), a GABAB agonist, rapidly and potently disinhibited the developing dentate, similar to its effect in the mature organism. CGP 35348, a GABAB antagonist, quickly reversed the baclofen-induced disinhibition. However, GABAB antagonists did not reverse long-latency (500-1000 ms IPI) paired-pulse depression, suggesting that it is not caused by a late GABAB-mediated IPSP. GABAB-mediated disinhibition of the dentate gyrus can occur by postnatal day 6, providing a powerful mechanism for altering excitability in the developing hippocampus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-3806(94)90206-2" target="_blank" rel="noreferrer noopener">10.1016/0165-3806(94)90206-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Animals
Baclofen/analogs & derivatives/pharmacology
Brain research. Developmental brain research
DiScenna P G
Electric Stimulation
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
GABA-A/drug effects/physiology
GABA-B Receptor Antagonists
GABA-B/*metabolism
Hippocampus/*growth & development/*metabolism
In Vitro Techniques
Nowicky A V
Organophosphorus Compounds/pharmacology
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00883.2006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00883.2006</a>
Pages
1018–1029
Issue
2
Volume
97
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Amino Acids/pharmacology; Animals; Chickens/*physiology; Cochlear Nucleus/*cytology/*physiology; Electric Stimulation; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/physiology; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; GABA-B/physiology; gamma-Aminobutyric Acid/*physiology; Glycine/analogs & derivatives/pharmacology; In Vitro Techniques; Kinetics; Membrane Potentials/drug effects; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology; Models; Neurological; Neurons/*physiology; Patch-Clamp Techniques; Receptors; Resorcinols/pharmacology; Synapses/physiology; Synaptic Transmission/*physiology; Xanthenes/pharmacology
Creator
An entity primarily responsible for making the resource
Lu Yong
Description
An account of the resource
GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic glutamate receptors (mGluRs) with whole cell recordings in brain slice preparations. I found that tACPD, a nonspecific mGluR agonist, exerted dose-dependent suppression on evoked inhibitory postsynaptic currents (eIPSCs) in NM neurons. At concentrations of 100 or 200 microM, tACPD increased the failure rate of GABAergic transmission. Agonists for group I (3,5-DHPG, 200 microM), group II (DCG-IV, 2 microM), and group III (L-AP4, 10 microM) mGluRs produced a significant reduction in the amplitude of eIPSCs and a significant increase in failure rate, indicating the involvement of multiple mGluRs in this modulation. The frequency, but not the amplitude, of miniature IPSCs (mIPSCs) was decreased significantly by 3,5-DHPG or DCG-IV. Neither frequency nor amplitude of mIPSCs was affected by L-AP4. mGluR antagonists LY341495 (20 microM) plus CPPG (10 microM) significantly increased the amplitude of eIPSCs, indicating that endogenous mGluR activity suppresses GABA release to NM neurons. Furthermore, blockage of mGluRs increased GABA-evoked discharges recorded under physiological Cl(-) concentrations, whereas tACPD (100 microM) eliminated them. The results indicate that mGluRs play important roles in achieving balanced excitation and inhibition in NM and preserving fidelity of temporal information encoded by NM neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00883.2006" target="_blank" rel="noreferrer noopener">10.1152/jn.00883.2006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2-Amino-5-phosphonovalerate/pharmacology
2007
Amino Acids/pharmacology
Animals
Chickens/*physiology
Cochlear Nucleus/*cytology/*physiology
Department of Anatomy & Neurobiology
Electric Stimulation
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/physiology
GABA-B Receptor Agonists
GABA-B Receptor Antagonists
GABA-B/physiology
gamma-Aminobutyric Acid/*physiology
Glycine/analogs & derivatives/pharmacology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lu Yong
Membrane Potentials/drug effects
Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology
Models
NEOMED College of Medicine
Neurological
Neurons/*physiology
Patch-Clamp Techniques
Receptors
Resorcinols/pharmacology
Synapses/physiology
Synaptic Transmission/*physiology
Xanthenes/pharmacology