1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.neurobiolaging.2019.04.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neurobiolaging.2019.04.007</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 99-110 Volume 80 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABAAR γ1 subunit during aging Publisher An entity responsible for making the resource available Neurobiology of Aging Date A point or period of time associated with an event in the lifecycle of the resource 2019 2019-08 Subject The topic of the resource Age-related hearing loss; GABAA receptor; GABAAR γ1 subunit; GABAergic; Glutamatergic; Inferior colliculus Creator An entity primarily responsible for making the resource Robinson Lauren C; Barat Oren; Mellott Jeffrey G Description An account of the resource Age-related hearing loss may result, in part, from declining levels of γ-amino butyric acid (GABA) in the aging inferior colliculus (IC). An upregulation of the GABAAR γ1 subunit, which has been shown to increase sensitivity to GABA, occurs in the aging IC. We sought to determine whether the upregulation of the GABAAR γ1 subunit was specific to GABAergic or glutamatergic IC cells. We used immunohistochemistry for glutamic acid decarboxylase and the GABAAR γ1 subunit at 4 age groups in the IC of Fisher Brown Norway rats. The percentage of somas that expressed the γ1 subunit and the number of subunits on each soma were quantified. Our results show that GABAergic and glutamatergic IC cells increasingly expressed the γ1 subunit from young age until expression peaked during middle age. At old age (∼77% of life span), the number of GABAAR γ1 subunits per cell sharply decreased for both cell types. These results, along with previous studies, suggest inhibitory and excitatory IC circuits may express the GABAAR γ1 subunit in response to the age-related decline of available GABA. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.neurobiolaging.2019.04.007" target="_blank" rel="noreferrer noopener">10.1016/j.neurobiolaging.2019.04.007</a> 2019 Age-related hearing loss Barat Oren Department of Anatomy & Neurobiology GABAA receptor GABAAR γ1 subunit GABAergic Glutamatergic inferior colliculus June 2019 Update Mellott Jeffrey G NEOMED College of Medicine Neurobiology of aging Robinson Lauren C