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<a href="http://doi.org/10.1016/j.neurobiolaging.2019.04.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neurobiolaging.2019.04.007</a>
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Pages
99-110
Volume
80
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Title
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GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABAAR γ1 subunit during aging
Publisher
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Neurobiology of Aging
Date
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2019
2019-08
Subject
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Age-related hearing loss; GABAA receptor; GABAAR γ1 subunit; GABAergic; Glutamatergic; Inferior colliculus
Creator
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Robinson Lauren C; Barat Oren; Mellott Jeffrey G
Description
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Age-related hearing loss may result, in part, from declining levels of γ-amino butyric acid (GABA) in the aging inferior colliculus (IC). An upregulation of the GABAAR γ1 subunit, which has been shown to increase sensitivity to GABA, occurs in the aging IC. We sought to determine whether the upregulation of the GABAAR γ1 subunit was specific to GABAergic or glutamatergic IC cells. We used immunohistochemistry for glutamic acid decarboxylase and the GABAAR γ1 subunit at 4 age groups in the IC of Fisher Brown Norway rats. The percentage of somas that expressed the γ1 subunit and the number of subunits on each soma were quantified. Our results show that GABAergic and glutamatergic IC cells increasingly expressed the γ1 subunit from young age until expression peaked during middle age. At old age (∼77% of life span), the number of GABAAR γ1 subunits per cell sharply decreased for both cell types. These results, along with previous studies, suggest inhibitory and excitatory IC circuits may express the GABAAR γ1 subunit in response to the age-related decline of available GABA.
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<a href="http://doi.org/10.1016/j.neurobiolaging.2019.04.007" target="_blank" rel="noreferrer noopener">10.1016/j.neurobiolaging.2019.04.007</a>
2019
Age-related hearing loss
Barat Oren
Department of Anatomy & Neurobiology
GABAA receptor
GABAAR γ1 subunit
GABAergic
Glutamatergic
inferior colliculus
June 2019 Update
Mellott Jeffrey G
NEOMED College of Medicine
Neurobiology of aging
Robinson Lauren C