1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1159/000079664" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000079664</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
296-304
Issue
6
Volume
79
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopamine Transporter As A Marker Of Neuroprotection In Methamphetamine-lesioned Mice Treated Acutely With Estradiol
Publisher
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Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
1905-06
Subject
The topic of the resource
17-beta-estradiol; brain; depletion; dopamine transporter; Endocrinology & Metabolism; estrogen; gender-differences; gonadal steroids; induced neurotoxicity; methamphetamine; neuroprotection; Neurosciences & Neurology; parkinsons-disease; progesterone; rat; striatal dopamine; striatum; substantia nigra; system
Creator
An entity primarily responsible for making the resource
D'Astous M; Gajjar T M; Dluzen D E; Di Paolo T
Identifier
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<a href="http://doi.org/10.1159/000079664" target="_blank" rel="noreferrer noopener">10.1159/000079664</a>
Format
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Journal Article or Conference Abstract Publication
17-beta-estradiol
2004
Brain
D'Astous M
depletion
Di Paolo T
Dluzen D E
Dopamine transporter
Endocrinology & Metabolism
estrogen
Gajjar T M
gender-differences
gonadal steroids
induced neurotoxicity
Methamphetamine
Neuroendocrinology
Neuroprotection
Neurosciences & Neurology
parkinsons-disease
progesterone
rat
striatal dopamine
striatum
SUBSTANTIA nigra
system
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00702-003-0045-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00702-003-0045-3</a>
Pages
1215–1224
Issue
11
Volume
110
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute effects of estrogen upon methamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-11
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Dopamine/metabolism; Drug Interactions; Estrogens/metabolism/*pharmacology; Female; Methamphetamine/antagonists & inhibitors/*toxicity; Mice; Neostriatum/*drug effects/metabolism/physiopathology; Neural Pathways/*drug effects/metabolism/physiopathology; Neuroprotective Agents/metabolism/pharmacology; Neurotoxins/antagonists & inhibitors/toxicity; Ovariectomy; Parkinson Disease/drug therapy/metabolism/physiopathology; Presynaptic Terminals/drug effects/metabolism; Reaction Time/drug effects/physiology; Sex Factors; Substantia Nigra/*drug effects/metabolism/physiopathology
Creator
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Gajjar T M; Anderson L I; Dluzen D E
Description
An account of the resource
Estrogen acts as a neuroprotectant of the nigrostriatal dopaminergic system when given chronically to female mice prior to Methamphetamine (MA) insult. In this report, we tested the acute effects of Estradiol Benzoate (EB-10 microg in Oil) in ovariectomized CD-1 mice to function as a neuroprotectant when administered prior to (Experiment 1) or after (Experiment 2) MA treatment. Striatal dopamine (DA) concentrations and DOPAC/DA ratios were measured to assess the neuroprotective effects of EB. In Experiment 1, we observed that EB exerted a neuroprotective effect upon striatal dopamine concentrations when administered at 24 and 12, but not at 0.5, hours prior to MA injection and upon DOPAC/DA ratios when administered at 24, 12 and 0.5 hours prior to MA. In Experiment 2, no evidence for estrogen to protect the striatum from MA insult was obtained when EB was administered at 15, 30, 60 or 120 minutes after MA. These results show that EB can act as a modulator of MA-induced nigrostriatal dopaminergic neurotoxicity suggestive of a neuroprotectant, when administered within 0.5 hour of MA insult as assessed by measures of DOPAC/DA, but fails to prevent depletion of DA when given after MA insult. The data suggest that estrogen may exert this rapid neuroprotective effect through a non-genomic mechanism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00702-003-0045-3" target="_blank" rel="noreferrer noopener">10.1007/s00702-003-0045-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
3
4-Dihydroxyphenylacetic Acid/metabolism
Anderson L I
Animals
Dluzen D E
Dopamine/metabolism
Drug Interactions
Estrogens/metabolism/*pharmacology
Female
Gajjar T M
Journal of neural transmission (Vienna, Austria : 1996)
Methamphetamine/antagonists & inhibitors/*toxicity
Mice
Neostriatum/*drug effects/metabolism/physiopathology
Neural Pathways/*drug effects/metabolism/physiopathology
Neuroprotective Agents/metabolism/pharmacology
Neurotoxins/antagonists & inhibitors/toxicity
Ovariectomy
Parkinson Disease/drug therapy/metabolism/physiopathology
Presynaptic Terminals/drug effects/metabolism
Reaction Time/drug effects/physiology
Sex Factors
Substantia Nigra/*drug effects/metabolism/physiopathology