1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1166/jbn.2013.1598" target="_blank" rel="noreferrer noopener">http://doi.org/10.1166/jbn.2013.1598</a> Pages 1029–1040 Issue 6 Volume 9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate-loaded gelucire-stabilized nanoparticles. Publisher An entity responsible for making the resource available Journal of biomedical nanotechnology Date A point or period of time associated with an event in the lifecycle of the resource 2013 2013-06 Subject The topic of the resource *Lethal Dose 50; Adenocarcinoma/*drug therapy/pathology; Animals; Antineoplastic Agents/administration & dosage/pharmacokinetics/toxicity; Cell Line; Dose-Response Relationship; Drug; Drug Stability; Drug Tolerance; Gallium/*administration & dosage/pharmacokinetics/*toxicity; Humans; Metabolic Clearance Rate; Mice; Nanocapsules/*administration & dosage/chemistry/*toxicity; Nude; Organ Specificity; Tissue Distribution; Treatment Outcome; Triglycerides/chemistry; Tumor Creator An entity primarily responsible for making the resource Wehrung Daniel; Bi Lipeng; Geldenhuys Werner J; Oyewumi Moses O Description An account of the resource The widespread clinical success with most gallium compounds in cancer therapy is markedly hampered by lack of tumor specific accumulation, poor tumor permeability and undesirable toxicity to healthy tissues. The aim of this work was to investigate for the first time antitumor mechanism of a new gallium compound (gallium acetylacetonate; GaAcAc) while assessing effectiveness of gelucire-stabilized nanoparticles (NPs) for potential application in gallium-based lung cancer therapy. NPs loaded with GaAcAc (Ga-NPs) were prepared using mixtures of cetyl alcohol with Gelucire 44/14 (Ga-NP-1) or Gelucire 53/13 (Ga-NP-2) as matrix materials. Of special note from this work is the direct evidence of involvement of microtubule disruption in antitumor effects of GaAcAc on human lung adenocarcinoma (A549). In-vivo tolerability studies were based on plasma ALT, creatinine levels and histopathological examination of tissues. The superior in-vivo antitumor efficacy of Ga-NPs over GaAcAc was depicted in marked reduction of tumor weight and tumor volume as well as histological assessment of excised tumors. Compared to free GaAcAc, Ga-NPs showed a 3-fold increase in tumor-to-blood gallium concentrations with minimized overall exposure to healthy tissues. Overall, enhancement of antitumor effects of GaAcAc by gelucire-stabilized NPs coupled with reduced exposure of healthy tissues to gallium would likely ensure desired therapeutic outcomes and safety of gallium-based cancer treatment. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1166/jbn.2013.1598" target="_blank" rel="noreferrer noopener">10.1166/jbn.2013.1598</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Lethal Dose 50 2013 Adenocarcinoma/*drug therapy/pathology Animals Antineoplastic Agents/administration & dosage/pharmacokinetics/toxicity Bi Lipeng Cell Line Department of Pharmaceutical Sciences Dose-Response Relationship Drug Drug Stability Drug Tolerance Gallium/*administration & dosage/pharmacokinetics/*toxicity Geldenhuys Werner J Humans Journal of biomedical nanotechnology Metabolic Clearance Rate Mice Nanocapsules/*administration & dosage/chemistry/*toxicity NEOMED College of Pharmacy Nude Organ Specificity Oyewumi Moses O Tissue Distribution Treatment Outcome Triglycerides/chemistry Tumor Wehrung Daniel