Testosterone-induced vasorelaxation of porcine coronary artery involves K+ channel activation
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Deenadavalu V; Gao X; White R E; Stallone J N
Faseb Journal
1998
1998-03
Journal Article or Conference Abstract Publication
n/a
Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice.
Animals; Body Weight/genetics; Brain-Derived Neurotrophic Factor/*deficiency/genetics/*metabolism; Corpus Striatum/*metabolism; Dopamine/*metabolism; Heterozygote; Homozygote; Hypothalamus/metabolism; Methamphetamine/pharmacology; Mice; Motor Activity/drug effects/physiology; Mutant Strains; Norepinephrine/metabolism; Olfactory Bulb/metabolism; Organ Specificity; Substantia Nigra/*metabolism; Walking/physiology
Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice. In the present report we evaluated various indices of nigrostriatal dopaminergic function between
Dluzen D E; Gao X; Story G M; Anderson L I; Kucera J; Walro J M
Experimental neurology
2001
2001-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1006/exnr.2001.7698" target="_blank" rel="noreferrer noopener">10.1006/exnr.2001.7698</a>
The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.
Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Drug Implants; Female; Male; Methamphetamine/*toxicity; Mice; Neuroprotective Agents/pharmacology; Neurotoxins/*toxicity; Orchiectomy; Ovariectomy; Potassium/pharmacology; Substantia Nigra/drug effects/*metabolism; Testosterone/administration & dosage/*pharmacology
The gonadal steroid hormone estrogen (E) can function as a neuroprotectant of nigrostriatal dopaminergic (NSDA) neurotoxicity, however, there exists very limited information on the role of testosterone (T) in this capacity. In the present report, the effects of T on methamphetamine (MA) induced neurotoxicity of the NSDA system were examined in gonadectomized female and male CD-1 mice. In Experiment 1, striatal dopamine (DA) concentrations and output from T-treated ovariectomized mice were not significantly different from that of non-T-treated mice following MA. These results suggest that T is not functioning as a modulator of MA-induced NSDA neurotoxicity in ovariectomized CD-1 mice. In Experiment 2, there were no significant differences in DA concentrations or output among
Gao X; Dluzen D E
Brain research
2001
2001-02
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/s0006-8993(00)03221-2" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)03221-2</a>
Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.
Animals; Corpus Striatum/chemistry/*drug effects/metabolism; Dopamine/analysis/*metabolism; Estrogen Antagonists/*pharmacology; Estrogens/blood/*pharmacology; Female; Inbred Strains; Methamphetamine/*toxicity; Mice; Neuroprotective Agents/pharmacology; Ovariectomy; Substantia Nigra/chemistry/*drug effects/metabolism; Sympathomimetics/*toxicity; Tamoxifen/*pharmacology
The effects of 17beta-estradiol and the anti-estrogen, tamoxifen, on methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in ovariectomized CD-1 mice. In Experiment 1, striatal dopamine concentrations from estrogen treated mice were significantly greater than that from non-estrogen treated mice following methamphetamine. Dopamine concentrations from estrogen+tamoxifen+methamphetamine treated mice were decreased compared to estrogen+methamphetamine treated mice and not significantly different from those of tamoxifen+methamphetamine treated mice or mice receiving methamphetamine alone. These results suggest that estrogen is functioning as a neuroprotectant of methamphetamine-induced nigrostriatal dopaminergic neurotoxicity and that this neuroprotective effect of estrogen is abolished in the presence of tamoxifen. In Experiment 2, estrogen administration after methamphetamine treatment did not produce any significant changes in dopamine concentrations compared with methamphetamine treatment alone. The data from Experiment 2 show that estrogen cannot reverse the methamphetamine-induced neurotoxicity upon the nigrostriatal dopaminergic system. Similar results were observed for the potassium-stimulated dopamine outputs from these treatment conditions as evaluated with in vitro superfusion, although a difference between the two measures for the estrogen+methamphetamine treated group was obtained in Experiment 1. These results have important implications for estrogen-tamoxifen interactions upon the nigrostriatal dopaminergic system and the gender differences which are observed in Parkinson's disease and animal models of nigrostriatal dopaminergic neurotoxicity as well as for the proposed use of tamoxifen in pre-menopausal women at risk for breast cancer.
Gao X; Dluzen D E
Neuroscience
2001
1905-6
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/s0306-4522(01)00014-8" target="_blank" rel="noreferrer noopener">10.1016/s0306-4522(01)00014-8</a>
Estrogen Protects, But Does Not Restore, Nigrostriatal Dopaminergic Function In Methamphetamine Treated Mice
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Gao X; Dluzen D E
Faseb Journal
2000
2000-05
Journal Article or Conference Abstract Publication
n/a