1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ajpath.2017.06.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajpath.2017.06.001</a>
Pages
1658–1659
Issue
8
Volume
187
Dublin Core
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Title
A name given to the resource
Linking Sex Differences in Non-Alcoholic Fatty Liver Disease to Bile Acid Signaling, Gut Microbiota, and High Fat Diet.
Publisher
An entity responsible for making the resource available
The American journal of pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-08
Subject
The topic of the resource
*Diet; *Non-alcoholic Fatty Liver Disease; Bile Acids and Salts; Gastrointestinal Microbiome; High-Fat; Humans; Sex Characteristics
Creator
An entity primarily responsible for making the resource
Chiang John Y L
Description
An account of the resource
This commentary highlights the article by Jena et al that studied the complex interplay between diet, bile acids, sex, and dysbiosis in hepatic steatosis and inflammation.
Identifier
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<a href="http://doi.org/10.1016/j.ajpath.2017.06.001" target="_blank" rel="noreferrer noopener">10.1016/j.ajpath.2017.06.001</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Diet
*Non-alcoholic Fatty Liver Disease
2017
Bile Acids and Salts
Chiang John Y L
Department of Integrative Medical Sciences
Gastrointestinal Microbiome
High-Fat
Humans
NEOMED College of Medicine
Sex Characteristics
The American journal of pathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4093/dmj.2019.0043" target="_blank" rel="noreferrer noopener">http://doi.org/10.4093/dmj.2019.0043</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
257-272
Issue
3
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets
Publisher
An entity responsible for making the resource available
Diabetes & Metabolism Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
The topic of the resource
Bile acids and salts; cytoplasmic and nuclear; G-protein-coupled; Gastrointestinal microbiome; Non-alcoholic fatty liver disease; Receptors
Creator
An entity primarily responsible for making the resource
Ferrell Jessica M; Chiang John Y L
Description
An account of the resource
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4093/dmj.2019.0043" target="_blank" rel="noreferrer noopener">10.4093/dmj.2019.0043</a>
2019
Bile Acids and Salts
Chiang John Y L
Cytoplasmic and Nuclear
Department of Integrative Medical Sciences
Diabetes & Metabolism Journal
Ferrell Jessica M
G-protein-coupled
Gastrointestinal Microbiome
June 2019 Update
NEOMED College of Medicine
Non-alcoholic Fatty Liver Disease
Receptors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-43-257.pdf" target="_blank" rel="noreferrer noopener">http://doi.org/10.4093/dmj.2019.0043</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
257-272
Issue
3
Volume
43
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.
Publisher
An entity responsible for making the resource available
Diabetes & Metabolism Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
The topic of the resource
BILE acids; Bile acids and salts; cholesterol 7-alpha-hydroxylase; Cytoplasmic and Nuclear; Endocrinology & Metabolism; FARNESOID X receptor; farnesoid-x-receptor; FATTY liver; fatty liver-disease; G protein coupled receptors; G-protein-coupled; Gastrointestinal microbiome; growth-factor 19; gut microbiota; hepatic steatosis; improves insulin sensitivity; liver disease; metabolic; Non-alcoholic fatty; Non-alcoholic Fatty Liver Disease; nuclear; receptor; Receptors; serum fgf21 levels; syndrome
Creator
An entity primarily responsible for making the resource
Ferrell Jessica M; Chiang John Y L
Description
An account of the resource
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and nonalcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in the intestine by gut bacteria. Bile acids are nutrient sensors and metabolic integrators that regulate lipid, glucose, and energy homeostasis by activating nuclear farnesoid X receptor and membrane Takeda G protein-coupled receptor 5. Bile acids control gut bacteria overgrowth, species population, and protect the integrity of the intestinal barrier. Gut bacteria, in turn, control circulating bile acid composition and pool size. Dysregulation of bile acid homeostasis and dysbiosis causes diabetes and obesity. Targeting bile acid signaling and the gut microbiome have therapeutic potential for treating diabetes, obesity, and non-alcoholic fatty liver disease. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4093/dmj.2019.0043" target="_blank" rel="noreferrer noopener">10.4093/dmj.2019.0043</a>
2019
BILE acids
Bile Acids and Salts
Chiang John Y L
cholesterol 7-alpha-hydroxylase
Cytoplasmic and Nuclear
Department of Integrative Medical Sciences
Diabetes & Metabolism Journal
Endocrinology & Metabolism
Farnesoid X receptor
farnesoid-x-receptor
Fatty Liver
fatty liver-disease
Ferrell Jessica M
G protein coupled receptors
G-protein-coupled
Gastrointestinal Microbiome
growth-factor 19
gut microbiota
hepatic steatosis
improves insulin sensitivity
Liver disease
Metabolic
NEOMED College of Medicine
Non-alcoholic fatty
Non-alcoholic Fatty Liver Disease
nuclear
Receptor
Receptors
September 2019 Update
serum fgf21 levels
Syndrome