Browse Items (61 total)
- Tags: Geldenhuys Werner J
Novel models for assessing blood-brain barrier drug permeation.
Tags: *Capillary Permeability, 2012, Allen David D, Animal, Animals, Blood-Brain Barrier/*metabolism, Bloomquist Jeffrey R, Drosophila melanogaster/metabolism, Expert opinion on drug metabolism & toxicology, Geldenhuys Werner J, Grasshoppers/metabolism, High-Throughput Screening Assays, Humans, Models, Pharmaceutical Preparations/*metabolism, Zebrafish/metabolism
Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.
Tags: 2007, Alzheimer Disease/pathology/*prevention & control, Amit Tamar, Animals, Avramovich Yael, Bar Am Orit, Biological, Central Nervous System/chemistry/*drug effects/metabolism, Current Alzheimer research, Drug Design, Fridkin Mati, Gal Shunit, Geldenhuys Werner J, Humans, Mandel Silvia, Models, Neuroprotective Agents/*chemistry/pharmacology/*therapeutic use, Neurotransmitter Agents/chemistry/*metabolism, Sagi Yotam, Van der Schyf Cornelis J, Weinreb Orly, Youdim Moussa B H, Zheng Hailin
Novel thiazolidinedione mitoNEET ligand-1 acutely improves cardiac stem cell survival under oxidative stress.
Tags: 2015, Animals, Basic research in cardiology, Cardiac/cytology/*drug effects, Carroll Richard T, Cell Differentiation/drug effects, Chilian William M, Department of Integrative Medical Sciences, Enrick Molly K, Flow Cytometry, Geldenhuys Werner J, Knockout, Kolz Christopher L, Logan Suzanna J, Male, Mice, Mitochondrial Membranes/metabolism, Mitochondrial Proteins/metabolism, Myocytes, NEOMED College of Medicine, Ohanyan Vahagn A, Oxidative Stress/drug effects/*physiology, Rats, Real-Time Polymerase Chain Reaction, Stem Cells/cytology/*drug effects, Stevanov Kelly M, Thiazolidinediones/*pharmacology, Yin Liya, Zucker
Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling.
Tags: *MAP Kinase Signaling System, *Signal Transduction, 2016, Abdelmagid Samir M, Animals, Cell Differentiation, Cells, Cultured, Department of Anatomy & Neurobiology, Experimental & molecular medicine, Eye Proteins/*metabolism, Geldenhuys Werner J, Hyaluronan Receptors/*metabolism, Inbred C57BL, Jaber Fatima A, Male, Mbimba Thomas S, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, Novak Kimberly, Osteoclasts/*cytology/metabolism, RANK Ligand/metabolism, Recombinant Proteins/metabolism, Safadi Fayez F, Sondag Gregory R, Yu Bing
Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents.
Tags: 2010, Alzheimer Disease/*physiopathology/*therapy, Animals, Antioxidants/*administration & dosage/chemistry/pharmacology, Bishayee Anupam, Carroll Richard T, Darvesh Altaf S, Department of Pharmaceutical Sciences, Expert review of neurotherapeutics, Flavonoids/*administration & dosage/chemistry/pharmacology, Geldenhuys Werner J, Humans, Mitochondria/drug effects/physiology, NEOMED College of Pharmacy, Neurodegenerative Diseases/physiopathology, Oxidative Stress/drug effects/*physiology, Phenols/*administration & dosage/chemistry/pharmacology, Polyphenols, Van der Schyf Cornelis J
Parkinson's disease biomarker: a patent evaluation of WO2013153386.
Tags: 2014, Abdelmagid Samir M, Autophagy, Biomarkers/metabolism, clinical testing, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Disease Progression, Dopaminergic Neurons/pathology, Expert opinion on therapeutic patents, Gallegos Patrick J, Geldenhuys Werner J, Humans, Mitochondria/pathology, mitochondrial membrane potential, mitophagy, NEOMED College of Medicine, NEOMED College of Pharmacy, Parkinson Disease/*diagnosis/physiopathology, Patents as Topic, Phosphorylation, Protein Kinases/*metabolism, Safadi Fayez F, Ubiquitin-Protein Ligases/*metabolism
Pharmacotherapy of Alzheimer's disease: current and future trends.
Tags: 2015, Alzheimer Disease/*drug therapy, Alzheimer's disease, Anti-Inflammatory Agents, Antioxidants, cholinesterase inhibitors, Darvesh Altaf S, dementia, Department of Pharmaceutical Sciences, Drug Therapy/*methods/*trends, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, immunotherapy, memantine, multi-targeted drugs, natural products, NEOMED College of Pharmacy, Pharmacotherapy
Polycyclic compounds: ideal drug scaffolds for the design of multiple mechanism drugs?
Tags: *Drug Design, 2009, Adamantane/chemistry/pharmacology, Animals, Central Nervous System Diseases/*drug therapy, Geldenhuys Werner J, Humans, Molecular Structure, Neuroprotective Agents/chemistry/*pharmacology/therapeutic use, Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, Polycyclic Compounds/*chemistry/pharmacology/therapeutic use, Psychotropic Drugs/chemistry/*pharmacology/therapeutic use, Quantitative Structure-Activity Relationship, Van der Schyf Cornelis J
Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization.
Tags: *Cell Movement, 2012, AbouAlaiwi Wissam A, Actin Cytoskeleton/*metabolism, Adapala Ravi K, Animals, Blotting, Bursley Chris, Capillary Permeability/*physiology, Cell Adhesion, Cilia/metabolism, Department of Integrative Medical Sciences, Endothelial Cells/cytology/*metabolism, Fluorescent Antibody Technique, Focal Adhesions/metabolism, Geldenhuys Werner J, HSP27 Heat-Shock Proteins/*metabolism, Jones Thomas J, Journal of cellular physiology, Mice, Nauli Surya M, NEOMED College of Medicine, Polycystic Kidney Diseases/physiopathology, Signal Transduction/physiology, Thodeti Charles K, Transgenic, Western
Role of serotonin in Alzheimer's disease: a new therapeutic target?
Tags: 2011, Alzheimer Disease/*drug therapy/*metabolism, Alzheimer's Disease – Drug Therapy, Alzheimer's Disease – Metabolism, Animals, Cell Surface – Metabolism, Clinical Trials, Clinical Trials as Topic, CNS drugs, Drug Evaluation, Geldenhuys Werner J, Humans, Preclinical, Receptors, Serotonin – Pharmacodynamics, Serotonin – Therapeutic Use, Serotonin/*metabolism, Serotonin/*pharmacology/*therapeutic use, Van der Schyf Cornelis J
Screening and identification of novel compounds with potential anti-proliferative effects on gallium-resistant lung cancer through an AXL kinase pathway.
Tags: 2014, Alazizi Adnan, Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology, Antitumor, AXL, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Resistance, Drug Screening Assays, Gallium, Gallium-resistance, Gallium/pharmacology, Geldenhuys Werner J, Humans, Lin Li, Liva Sophia, Lung cancer, Lung Neoplasms/drug therapy/*enzymology/*pathology, Molecular Structure, Naphthalenes/chemistry/*pharmacology, NEOMED College of Pharmacy, Neoplasm/drug effects, Oyewumi Moses O, Proto-Oncogene Proteins/*antagonists & inhibitors/metabolism, Pyrazoles/chemistry/*pharmacology, Quinolines/chemistry/*pharmacology, Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism, Structure-Activity Relationship, Tetrazoles/chemistry/*pharmacology, Tumor, Virtual screening
Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease.
Structure-activity and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.
Tags: *Diabetes, *High-fat diet, *Homology modeling, *Hyperlipidemia, *Lipoprotein lipase, *Liver cirrhosis, *Obesity, 2017, Animals, Benzeneacetamides/chemical synthesis/chemistry/*pharmacology, Bioorganic & medicinal chemistry letters, Caporoso Joel, Darvesh Altaf S, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dose-Response Relationship, Drug, Geldenhuys Werner J, Imidazoles/chemical synthesis/chemistry/*pharmacology, Lee Yoon-Kwang, Leeper Thomas C, Lin Li, Lipoprotein Lipase/*metabolism, Mice, Molecular Docking Simulation, Molecular Structure, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Sadana Prabodh, Structure-Activity Relationship
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.
Tags: 2011, Animals, Awale Prabha S, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dluzen Dean E, Funk Max O, Geldenhuys Werner J, Humans, Inbred C57BL, Male, Mice, Models, Molecular, Molecular Structure, Monoamine Oxidase Inhibitors/chemical synthesis/chemistry/*pharmacology, Monoamine Oxidase/*metabolism, Stereoisomerism, Stinnett Hilary, Structure-Activity Relationship, Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
Structure-activity relationships of pentacycloundecylamines at the
Tags: 2007, Amines/chemical synthesis/chemistry/*pharmacology, Animals, Bioorganic & medicinal chemistry, Bloomquist Jeffrey R, Brain/drug effects, Dizocilpine Maleate/pharmacology, Excitatory Amino Acid Antagonists/*pharmacology, Geldenhuys Werner J, Inbred ICR, Ion Channels, Malan Sarel F, Male, Mice, Models, Molecular, N-Methyl-D-Aspartate/*antagonists & inhibitors, Phencyclidine/analogs & derivatives, Piperidines/pharmacology, Radioligand Assay, Receptors, Structure-Activity Relationship, Synaptosomes/*drug effects, Thiophenes/pharmacology, Van der Schyf Cornelis J
Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.
Tags: *Drug Design, 2010, Animals, Barnes Kendra F, Binding Sites/drug effects/physiology, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dose-Response Relationship, Drug, Drug Delivery Systems/*methods, Funk Max O, Geldenhuys Werner J, Liver/drug effects/metabolism, Mitochondria, Mitochondrial Proteins/*metabolism, Protein Structure, Rats, Secondary, Structure-Activity Relationship, Thiazolidinediones/administration & dosage/*chemical synthesis/*metabolism
Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers.
Tags: 2016, Alicyclic/chemical synthesis/*chemistry/pharmacology, Amines/chemical synthesis/*chemistry/pharmacology, Animals, Apoptosis/drug effects, Archiv der Pharmazie, Calcium Channel Blockers/chemical synthesis/*chemistry/pharmacology, Calcium Channels, Calcium/*metabolism, Cell Survival/drug effects, Domingo Olwen C, Geldenhuys Werner J, Hydrocarbons, Hydrogen Peroxide/pharmacology, L-Lactate Dehydrogenase/metabolism, L-type calcium channel (LTCC) blockers, L-Type/*metabolism, Malan Sarel F, Multifunctional drugs, Neurodegeneration, PC12 Cells, Pentacycloundecylamine, Quinones/chemical synthesis/*chemistry/pharmacology, Rats, Structure-Activity Relationship, Triquinylamine, Van der Schyf Cornelis J, Young Lois-May
The blood-brain barrier choline transporter.
Tags: 2012, Allen David D, Animals, Blood-Brain Barrier/drug effects/*metabolism, Central nervous system agents in medicinal chemistry, Drug Delivery Systems/*methods, Geldenhuys Werner J, Humans, Membrane Transport Proteins/*metabolism, Organic Cation Transport Proteins/metabolism, Organic Cation Transporter 1/metabolism, Organic Cation Transporter 2
The emergence of designed multiple ligands for neurodegenerative disorders.
Tags: *Drug Design, *Ligands, 2011, Amyloid beta-Peptides/metabolism, Antiparkinson Agents/therapeutic use, Carroll Richard T, Clinical Trials as Topic, Geldenhuys Werner J, Humans, Molecular Structure, Neurodegenerative Diseases/*drug therapy, Neuroprotective Agents/*therapeutic use, Progress in neurobiology, Van der Schyf Cornelis J, Youdim Moussa B H
The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease.
Tags: 2009, Alzheimer Disease/*complications, Animals, Biological, Cognition Disorders/*drug therapy/*etiology, Drug Design, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, Models, Receptors, Serotonin Antagonists/chemistry/*therapeutic use, Serotonin/*metabolism, Structure-Activity Relationship, Van der Schyf Cornelis J
Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor.
Tags: *Models, *Narcotic Antagonists, *Quantitative Structure-Activity Relationship, 2010, Animals, Binding, Calcium Signaling/drug effects, CHO Cells, Competitive, Cricetinae, Cricetulus, Databases, Factual, Geldenhuys Werner J, Humans, Journal of medicinal chemistry, Kuzenko Stephanie R, Ligands, Molecular, Neurokinin-3/*antagonists & inhibitors/chemistry, Opioid/chemistry, Quinolines/*chemistry/pharmacology, Radioligand Assay, Receptors, Simmons Mark A