Browse Items · NEOMED Bibliography Database

A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.

Cholesterol 7alpha-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3'-untranslated region (3'-UTR). However, the…

Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.

Trivalent chromium (Cr(3+)) is a mineral nutrient reported to have beneficial effects in glycemic and cardiovascular health. In vitro and in vivo studies suggest that Cr(3+) supplementation reduces the atherogenic potential and lowers the risk of…

Tags: 2015, American journal of physiology. Cell physiology, Aorta/drug effects/metabolism, Cell Proliferation/*drug effects/genetics, Cells, Chavez Ronaldo J, Chromium/*pharmacology, Cultured, Department of Integrative Medical Sciences, Fructosephosphates/metabolism, Ganguly Rituparna, Genetic/drug effects/genetics, Glucose/*metabolism, Glutamine/genetics, Glycosylation/drug effects, Hexosamines/metabolism, Humans, Hyperglycemia/metabolism, Muscle, Myocytes, N-Acetylglucosaminyltransferases/genetics, NEOMED College of Medicine, O-glycosylation, Promoter Regions, Raman Priya, reactive oxygen species, Reactive Oxygen Species/metabolism, Sahu Soumyadip, Signal Transduction/*drug effects/genetics, Smooth, Smooth Muscle/*drug effects/metabolism, Thrombospondin 1/*antagonists & inhibitors/genetics, thrombospondin-1, Transcription, trivalent chromium, vascular smooth muscle cells, Vascular/*drug effects/metabolism

Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.

Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme responsible for eliminating approximately 20% of marketed drugs. Studies have shown that differential transcriptional regulation of CYP2D6 may contribute to large interindividual…

Browse Items (3 total)

A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.

Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.

Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.