1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2174/138920112798868548" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/138920112798868548</a>
Pages
117–124
Issue
1
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Natural products of dietary origin as lead compounds in virtual screening and drug design.
Publisher
An entity responsible for making the resource available
Current pharmaceutical biotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
Humans; Animals; Diet; Resveratrol; *Drug Design; *Biological Products/pharmacology; Caffeine/pharmacology; Curcumin/pharmacology; Genistein/pharmacology; Stilbenes/pharmacology
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Bishayee Anupam; Darvesh Altaf S; Carroll Richard T
Description
An account of the resource
Natural products have been found to be useful in the treatment of several diseases across the ages. In this article, we review the use of natural products, obtained from dietary sources, as lead compounds in developing novel therapeutic agents. These compounds have shown tremendous promise in the prevention and as well as treatment of a variety of chronic ailments. In addition, to being patentable and biocompatible, these compounds are a rich source of novel scaffolds to invigorate the pipelines of the pharmaceutical industry. In this communication, we also focus on studies which show how natural products have proved useful as lead compounds in virtual screening and structure-based drug design programs. Natural dietary constituents, such as resveratrol, curcumin and caffeine as well as other compounds, are discussed to illustrate this approach.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2174/138920112798868548" target="_blank" rel="noreferrer noopener">10.2174/138920112798868548</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Biological Products/pharmacology
*Drug Design
2012
Animals
Bishayee Anupam
Caffeine/pharmacology
Carroll Richard T
Curcumin/pharmacology
Current pharmaceutical biotechnology
Darvesh Altaf S
Department of Pharmaceutical Sciences
Diet
Geldenhuys Werner J
Genistein/pharmacology
Humans
NEOMED College of Pharmacy
Resveratrol
Stilbenes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I</a>
Pages
373–379
Issue
4
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NMDA receptor-independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice.
Publisher
An entity responsible for making the resource available
Hippocampus
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1905-6
Subject
The topic of the resource
Animals; Calcium Channel Blockers/pharmacology; Dendrites/*physiology; Electric Stimulation; Enzyme Inhibitors/pharmacology; Genistein/pharmacology; Hippocampus/cytology/*physiology; In Vitro Techniques; Inbred Strains; Long-Term Potentiation/drug effects/*physiology; Male; N-Methyl-D-Aspartate/*physiology; Phenols/pharmacology; Protein-Tyrosine Kinases/antagonists & inhibitors; Pyramidal Cells/*physiology; Rats; Receptors; Verapamil/pharmacology
Creator
An entity primarily responsible for making the resource
Cavus I; Teyler T J
Description
An account of the resource
The ability of hippocampal CA1 basal synapses to express N-methyl-D-aspartate (NMDA) receptor-independent long-term potentiation (non-NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non-NMDA LTP. Non-NMDA LTP in basal and apical dendrites was induced using stimulation pattern similar to the sharp wave-associated CA3 bursts. Basal dendritic non-NMDA LTP was input-specific and displayed similar development and magnitude to the apical dendritic non-NMDA LTP. Both apical and basal dendritic non-NMDA potentiations were inhibited by the voltage-dependent calcium channel (VDCC) inhibitor verapamil and the tyrosine kinase inhibitors genistein and levandustin A. However, the difference in the degree and time course of these inhibitions suggests involvement of distinct mechanisms in the two dendritic subfields.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1098-1063(1998)8:4%3C373::AID-HIPO5%3E3.0.CO;2-I</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Animals
Calcium Channel Blockers/pharmacology
Cavus I
Dendrites/*physiology
Electric Stimulation
Enzyme Inhibitors/pharmacology
Genistein/pharmacology
Hippocampus
Hippocampus/cytology/*physiology
In Vitro Techniques
Inbred Strains
Long-Term Potentiation/drug effects/*physiology
Male
N-Methyl-D-Aspartate/*physiology
Phenols/pharmacology
Protein-Tyrosine Kinases/antagonists & inhibitors
Pyramidal Cells/*physiology
Rats
Receptors
Teyler T J
Verapamil/pharmacology