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The Physiologic Impact of Unilateral Recurrent Laryngeal Nerve (RLN) Lesion on Infant Oropharyngeal and Esophageal Performance.

Recurrent laryngeal nerve (RLN) injury in neonates, a complication of patent ductus arteriosus corrective surgery, leads to aspiration and swallowing complications. Severity of symptoms and prognosis for recovery are variable. We transected the RLN…

Tags: 2015, Animal, Animals, Aspiration, Ballester Ashley, Biological, Deglutition, Deglutition – Physiology, Deglutition disorders, Deglutition Disorders – Etiology, Deglutition Disorders – Physiopathology, Deglutition Disorders/*etiology/physiopathology, Deglutition/*physiology, Department of Anatomy & Neurobiology, Disease Models, Dysphagia, Esophagus, Esophagus – Physiopathology, Esophagus/*physiopathology, Fraley Luke, German Rebecca Z, Gould François D H, Gross Andrew, Human, Infant, Lammers Andrew R, Laryngeal Nerves – Injuries, Laryngeal Nerves – Physiopathology, Models, NEOMED College of Medicine, Ohlemacher Jocelyn, Oropharynx – Physiopathology, Oropharynx/*physiopathology, Recurrent laryngeal nerve, Recurrent Laryngeal Nerve Injuries/*complications/physiopathology, Recurrent Laryngeal Nerve/*physiopathology, Swine

Animal Models for Dysphagia Studies: What Have We Learnt So Far.

Research using animal models has contributed significantly to realizing the goal of understanding dysfunction and improving the care of patients who suffer from dysphagia. But why should other researchers and the clinicians who see patients day in…

Central nervous system integration of sensorimotor signals in oral and pharyngeal structures: oropharyngeal kinematics response to recurrent laryngeal nerve lesion.

Safe, efficient liquid feeding in infant mammals requires the central coordination of oropharyngeal structures innervated by multiple cranial and spinal nerves. The importance of laryngeal sensation and central sensorimotor integration in this system…

Impact of recurrent laryngeal nerve lesion on oropharyngeal muscle activity and sensorimotor integration in an infant pig model.

The successful performance of a swallow requires dynamic integration between a wide range of sensory inputs and muscle activities to produce the coordinated kinematics of oropharyngeal structures. Damage to the recurrent laryngeal nerve (RLN)…

Tags: 2018, Deglutition, DeLozier Katherine R, Department of Anatomy & Neurobiology, electromyography RLN, German Rebecca Z, Gould François D H, Journal of applied physiology (Bethesda, Md. : 1985), NEOMED College of Medicine, Ohlemacher Jocelyn, sensorimotor integration, swallowing, Thexton Allan J

Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson's Disease.

Swallowing disorders in Parkinson's disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a…

Muscle Logic: New Knowledge Resource for Anatomy Enables Comprehensive Searches of the Literature on the Feeding Muscles of Mammals.

BACKGROUND: In recent years large bibliographic databases have made much of the published literature of biology available for searches. However, the capabilities of the search engines integrated into these databases for text-based bibliographic…

Preterm birth disrupts the development of feeding and breathing coordination

All mammals must breathe and breathe continuously from birth. Similarly, all mammals, including infants, have high functional demands for feeding. However, the pathway that food takes through the pharynx interrupts respiration. The coordination…

Tags: 2019, aerodigestive, Bond Laura E, Buddington Randal K, Department of Anatomy & Neurobiology, Dysphagia, Feeding, German Rebecca Z, Gould François D H, Journal of Applied Physiology (Bethesda, Journal of Applied Physiology (Bethesda, Md.: 1985), June 2019 Update, Mayerl Christopher J, Md.: 1985), NEOMED College of Medicine, neonate, Premature, Stricklen Bethany M

Premature birth impacts bolus size and shape through nursing in infant pigs

BACKGROUND: The formation of a bolus of food is critical for proper feeding function, and there is substantial variation in the size and shape of a bolus prior to a swallow. Preterm infants exhibit decreased abilities to acquire and process food, but…

Tags: 2019, Bond Laura E, Department of Anatomy & Neurobiology, German Rebecca Z, Gould Francois D H, Journal Article, Mayerl Christopher J, Myrla Alexis M, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, November 2019 Update, Pediatric Research, Stricklen Bethany M

Specific Vagus Nerve Lesion Have Distinctive Physiologic Mechanisms of Dysphagia.

Swallowing is complex at anatomical, functional, and neurological levels. The connections among these levels are poorly understood, yet they underpin mechanisms of swallowing pathology. The complexity of swallowing physiology means that multiple…

Tags: 2019, Animal model, Department of Anatomy & Neurobiology, Dysphagia, Frontiers in neurology, German Rebecca Z, Gould François D H, Kinematics, Lammers Andrew R, Mayerl Christopher J, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Recurrent laryngeal nerve, Superior laryngeal nerve

Effects of Superior Laryngeal Nerve Lesion on Kinematics of Swallowing and Airway Protection in an Infant Pig Model.

The superior laryngeal nerve provides detailed sensory information from the mucosal surfaces of laryngeal structures superior to the vocal folds, including the valleculae. Injury to this nerve results in airway penetration and aspiration.…

Tags: 2020, Abid Saja, Airway, Animal model, biomechanics, Deglutition, Deglutition disorders, Department of Anatomy & Neurobiology, Ding Peng, Dysphagia, German Rebecca Z, Kinematics, Lammers Andrew R, NEOMED College of Medicine, Neural control, Superior laryngeal nerve, Swallow

Swallow Safety in Infant Pigs With and Without Recurrent Laryngeal Nerve Lesion.

Aerodigestive coordination is critical for safe feeding in mammals, and failure to do so can result in aspiration. Using an infant pig model, we analyzed the impact of recurrent laryngeal nerve (RLN) lesion on aerodigestive coordination and swallow…

Tags: 2020, aerodigestive, Animal model, Bond Laura E, Department of Anatomy & Neurobiology, Dysphagia, German Rebecca Z, Gould François D H, Mayerl Christopher J, NEOMED College of Medicine, NEOMED Postdoc Publications, neonate, Respiration, Stricklen Bethany M

Changes in the coordination between respiration and swallowing from suckling through weaning.

All mammals undergo weaning from milk to solid food. This process requires substantial changes to mammalian oropharyngeal function. The coordination of swallowing and respiration is a crucial component of maintaining airway function throughout…

Swallow Safety is Determined by Bolus Volume During Infant Feeding in an Animal Model.

Feeding difficulties are especially prevalent in preterm infants, although the mechanisms driving these difficulties are poorly understood due to a lack of data on healthy infants. One potential mechanism of dysphagia in adults is correlated with…

The effect of preterm birth, recurrent laryngeal nerve lesion, and postnatal maturation on hyoid and thyroid movements, and their coordination in infant feeding.

Movements of the hyoid and thyroid are critical for feeding. These structures are often assumed to move in synchrony, despite evidence that neurologically compromised populations exhibit altered kinematics. Preterm infants are widely considered to be…

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