1
40
10
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1055/s-0039-1696641" target="_blank" rel="noreferrer noopener">http://doi.org/10.1055/s-0039-1696641</a>
Pages
357-364
Issue
4
Volume
37
ISSN
1098-8785 0735-1631 0735-1631
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1055/s-0039-1696641" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1055/s-0039-1696641</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
Hospital List
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Association Between Features of Spontaneous Late Preterm Labor and Late Preterm Birth.
Publisher
An entity responsible for making the resource available
American Journal of Perinatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03
Subject
The topic of the resource
Humans; Pregnancy; Female; Risk Factors; Logistic Models; Infant Newborn; Sensitivity and Specificity; Prognosis; Gestational Age; Premature Birth; Glucocorticoids/administration & dosage; Pregnancy Trimester Third; Labor Stage First; Obstetric Labor Premature; Betamethasone/administration & dosage; Cervix Uteri; Parity; Respiratory Tract Diseases/prevention & control
Creator
An entity primarily responsible for making the resource
Glover AV; Battarbee AN; Gyamfi-Bannerman C; Boggess KA; Sandoval G; Blackwell SC; Tita ATN; Reddy UM; Jain L; Saade GR; Rouse DJ; Iams JD; Clark EAS; Chien EK; Peaceman AM; Gibbs RS; Swamy GK; Norton ME; Casey BM; Caritis SN; Tolosa JE; Sorokin Y; Manuck TA
Description
An account of the resource
OBJECTIVE: This study aimed to evaluate the association between clinical and examination features at admission and late preterm birth. STUDY DESIGN: The present study is a secondary analysis of a randomized trial of singleton pregnancies at 34(0/7) to 36(5/7) weeks' gestation. We included women in spontaneous preterm labor with intact membranes and compared them by gestational age at delivery (preterm vs. term). We calculated a statistical cut-point optimizing the sensitivity and specificity of initial cervical dilation and effacement at predicting preterm birth and used multivariable regression to identify factors associated with late preterm delivery. RESULTS: A total of 431 out of 732 (59%) women delivered preterm. Cervical dilation ≥ 4 cm was 60% sensitive and 68% specific for late preterm birth. Cervical effacement ≥ 75% was 59% sensitive and 65% specific for late preterm birth. Earlier gestational age at randomization, nulliparity, and fetal malpresentation were associated with late preterm birth. The final regression model including clinical and examination features significantly improved late preterm birth prediction (81% sensitivity, 48% specificity, area under the curve = 0.72, 95% confidence interval [CI]: 0.68-0.75, and p-value < 0.01). CONCLUSION: Four in 10 women in late-preterm labor subsequently delivered at term. Combination of examination and clinical features (including parity and gestational age) improved late-preterm birth prediction.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1055/s-0039-1696641" target="_blank" rel="noreferrer noopener">10.1055/s-0039-1696641</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
American Journal of Perinatology
Battarbee AN
Betamethasone/administration & dosage
Blackwell SC
Boggess KA
Caritis SN
Casey BM
Cervix Uteri
Chien EK
Clark EAS
Female
Gestational Age
Gibbs RS
Glover AV
Glucocorticoids/administration & dosage
Gyamfi-Bannerman C
Hospital List
Humans
Iams JD
Infant Newborn
Jain L
journalArticle
Labor Stage First
Logistic Models
Manuck TA
Norton ME
Obstetric Labor Premature
Parity
Peaceman AM
Pregnancy
Pregnancy Trimester Third
Premature Birth
Prognosis
Reddy UM
Respiratory Tract Diseases/prevention & control
Risk Factors
Rouse DJ
Saade GR
Sandoval G
Sensitivity and Specificity
Sorokin Y
Swamy GK
Tita ATN
Tolosa JE
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/jp.2008.121" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/jp.2008.121</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
13-19
Issue
1
Volume
29
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect Of Parity On Gestational Age At Delivery In Multiple Gestation Pregnancies
Publisher
An entity responsible for making the resource available
Journal of Perinatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-01
Subject
The topic of the resource
assisted conception; epidemiology; gestational age; multifetal gestation; Obstetrics & Gynecology; parity; Pediatrics; preterm birth; triplets; twins
Creator
An entity primarily responsible for making the resource
James S; Gil K M; Myers N A; Stewart J
Description
An account of the resource
Objective: To estimate the effect of parity on gestational age (GA) at birth in multifetal pregnancies. Study Design: Birth data from the public-access Matched Multiple Birth File produced by the National Center for Health Statistics from 1995 to 2000 were analyzed following IRB approval. GA, parity and demographic data were analyzed with parametric and nonparametric tests, including regression analysis, using SPSS. Result: Data from women with twin (n = 316 983), triplet (n = 11981), and quadruplet (n = 766) pregnancies were analyzed. A significantly higher proportion of nulliparous versus parous women were Caucasian (twins: 82 versus 77%; triplets: 91 versus 87%) and had more than 15 years of education (twins: 39 versus 24%; triplets: 55 versus 39%; quadruplets: 53 versus 35%). Mean GA was 5.6 days longer for twins, 5.4 days longer for triplets and 6.8 days longer for quadruplets born to parous versus nulliparous women. Caucasian and African-American parous women pregnant with twins or triplets delivered their babies at a later GA than their nulliparous counterparts at each level of education. GA at delivery increased as a function of age of the mother in nulliparous and parous women of twins or triplets, and at every age level, parous women delivered their babies at a later GA. A higher proportion of nulliparous women delivered before 24 weeks (twins: 2.9 versus 1.2%; triplets: 5.9 versus 2.5%; quadruplets: 8.3 versus 2.6%). The percentage of twins born at or after 32 weeks was 84.9% for nullipara and 90.1% for parous women; for triplets, corresponding figures were 61.4 and 69.6%; and for quadruplets the figures were 33.2 and 44.2%. The percentage of births at or after 36 weeks for nulliparous and parous women pregnant with twins was 54.8 and 63.2%, respectively. The majority of the gain in GA was observed between women who had no previous births and those who had one previous birth. In regression analysis, the effect of parity remained after controlling for demographic and risk factors known to affect GA. Conclusion: GA at delivery is significantly increased in parous women carrying a multifetal gestation after controlling for other factors that affect GA at birth.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/jp.2008.121" target="_blank" rel="noreferrer noopener">10.1038/jp.2008.121</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
assisted conception
Department of Family & Community Medicine
Epidemiology
Gestational Age
Gil K M
James S
Journal Article or Conference Abstract Publication
Journal of Perinatology
multifetal gestation
Myers N A
NEOMED College of Medicine
Obstetrics & Gynecology
Parity
Pediatrics
Preterm birth
Stewart J
triplets
Twins
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
222–228
Issue
3
Volume
15
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Delays in immunizations of high-risk infants during the first two years of life: special care for the high-risk infant should not mean special immunization schedules.
Publisher
An entity responsible for making the resource available
Journal of perinatology : official journal of the California Perinatal Association
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-06
Subject
The topic of the resource
Female; Humans; Male; Time Factors; Infant; Gestational Age; Follow-Up Studies; Risk Factors; Intensive Care Units; Physicians; Family; Parents/psychology; *Immunization Schedule; Immunization/*statistics & numerical data; Infant Care/*standards; Primary Health Care/*standards; Newborn; Practice Patterns; Physicians'; Premature; Neonatal
Creator
An entity primarily responsible for making the resource
Magoon M W; Belardo L J; Caldito G
Description
An account of the resource
Because experience in our newborn intensive care unit follow-up clinic since 1982 suggested that immunizations of newborn intensive care unit graduates in the first 2 years of life were inappropriately delayed, questionnaires were sent to families and to the four categories of primary care providers (family practitioners, pediatricians, local health clinics, and neonatalogists) in our region to assess immunization rates and practices. Delays in the first diphtheria, tetanus, and pertussis immunization and the polio vaccine were greater the less the birth weight and less the gestational age of the infant. Delays in subsequent immunizations were considerable and did not correlate with gestational age. A substantial proportion of primary care providers are not immunizing infants in compliance with the American Academy of Pediatrics recommendation, but some improvement is seen when the time period 1982 to 1986 is compared with 1987 to 1991.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Immunization Schedule
1995
Belardo L J
Caldito G
Family
Female
Follow-Up Studies
Gestational Age
Humans
Immunization/*statistics & numerical data
Infant
Infant Care/*standards
Intensive Care Units
Journal of perinatology : official journal of the California Perinatal Association
Magoon M W
Male
Neonatal
Newborn
Parents/psychology
Physicians
Physicians'
Practice Patterns
Premature
Primary Health Care/*standards
Risk Factors
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/01902148.2010.514024" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/01902148.2010.514024</a>
Pages
44–56
Issue
1
Volume
37
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lung fluid absorption is induced in preterm guinea pigs ventilated with low tidal volumes.
Publisher
An entity responsible for making the resource available
Experimental lung research
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-02
Subject
The topic of the resource
Time Factors; Animals; Gestational Age; Guinea Pigs; *Premature Birth; Phosphorylation; Enzyme Activation; Permeability; Extracellular Signal-Regulated MAP Kinases/metabolism; Intubation; Epithelial Sodium Channels/metabolism; Absorption; Sodium-Potassium-Exchanging ATPase/metabolism; Fetal Organ Maturity; Epinephrine/blood; Extravascular Lung Water/*metabolism; *Tidal Volume; Albumins/administration & dosage/*metabolism; Hydrocortisone/blood; Lung/embryology/*metabolism/physiopathology; MAP Kinase Kinase Kinases/metabolism; Ventilator-Induced Lung Injury/metabolism/physiopathology/*prevention & control; Newborn; Intratracheal; Artificial/adverse effects/*methods; Respiration
Creator
An entity primarily responsible for making the resource
Koshy Shyny; Beard LaMonta L; Kuzenko Stephanie R; Li Tianbo; Folkesson Hans G
Description
An account of the resource
The objective of this study was to determine if low tidal volume (V(t)) ventilation was beneficial when ventilating preterm fetuses. The authors ventilated preterm guinea pig fetuses at gestation day (GD) 67, 3 days before birth, newborn, and 10-day-old (PD10) guinea pigs with low V(t) (6 mL/kg body weight [bw]) and compared them to age-matched fetuses/animals ventilated with higher potentially injurious V(t) (12 mL/kg bw). Lung fluid absorption was measured after intratracheal instillation of 5% albumin in 0.9% NaCl. Low V(t) ventilation stimulated lung fluid absorption when compared to higher V(t) in all groups. The increased lung fluid absorption in low V(t)-ventilated fetuses was associated with increased alpha epithelial Na channel (alphaEnaC) mRNA. However, alphaENaC and betaENaC protein was unchanged over the 1-hour study. Because stretch induces mitogen-activated protein (MAP) kinase expression and MAP kinases may affect lung fluid absorption, the authors investigated if MAP kinase (MAPK) expression was affected by V(t). Extracellular signal-regulated kinase (ERK) and MAPK/ERK kinase (MEK) were phosphorylated in the higher V(t)-ventilated guinea pig fetuses. This suggested that a reduced activation of MAP kinases might explain the increased lung fluid absorption in the low V(t)-ventilated fetuses. Thus these data suggest that low V(t) ventilation increases fetal lung fluid absorption and thus may be preferential to use clinically.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/01902148.2010.514024" target="_blank" rel="noreferrer noopener">10.3109/01902148.2010.514024</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Premature Birth
*Tidal Volume
2011
Absorption
Albumins/administration & dosage/*metabolism
Animals
Artificial/adverse effects/*methods
Beard LaMonta L
Enzyme Activation
Epinephrine/blood
Epithelial Sodium Channels/metabolism
Experimental lung research
Extracellular Signal-Regulated MAP Kinases/metabolism
Extravascular Lung Water/*metabolism
Fetal Organ Maturity
Folkesson Hans G
Gestational Age
Guinea Pigs
Hydrocortisone/blood
Intratracheal
Intubation
Koshy Shyny
Kuzenko Stephanie R
Li Tianbo
Lung/embryology/*metabolism/physiopathology
MAP Kinase Kinase Kinases/metabolism
Newborn
Permeability
Phosphorylation
Respiration
Sodium-Potassium-Exchanging ATPase/metabolism
Time Factors
Ventilator-Induced Lung Injury/metabolism/physiopathology/*prevention & control
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0200087" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0200087</a>
Pages
e0200087–e0200087
Issue
7
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Twin-twin transfusion syndrome screening and diagnosis in the United States: A triangulation design of patient experiences.
Publisher
An entity responsible for making the resource available
PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-7
Subject
The topic of the resource
Adult; Female; Humans; Retrospective Studies; Ultrasonography; Cross-Sectional Studies; Fetofetal Transfusion/*diagnosis/*diagnostic imaging/*epidemiology; Gestational Age; Patient Reported Outcome Measures; Pregnancy; Prenatal Care/methods; Ultrasonography/methods; United States; Prenatal/methods
Creator
An entity primarily responsible for making the resource
Fischbein Rebecca; Nicholas Lauren; Aultman Julie; Baughman Kristin; Falletta Lynn
Description
An account of the resource
OBJECTIVE: Using patient-reported experiences, this study: 1) quantitatively evaluated TTTS screening trends, 2) examined screening and diagnostic experiences using a mixed methods approach, and 3) determined gaps in clinical care experiences. DESIGN: This was a cross-sectional study. Data was collected using a self-report, retrospective survey. A triangulation design was used to validate quantitative survey data with thematically analyzed qualitative data. SETTING: Participants were recruited through social media and national foundations and completed the survey online. PARTICIPANTS: Participants were 312 women who completed a TTTS pregnancy in the United States, representing the largest survey of participants who have experienced TTTS. METHODS: Descriptive statistics and bivariate analyses were conducted. Multivariate logistic regression examined predictors of ultrasound frequency. Qualitative data were initially coded by hand and checked using qualitative software. RESULTS: The percentages of participants reporting guideline recommended screening, including identification of pregnancy type by gestational week 13 and timely receipt of ultrasounds, increased over time. However, 44.6% of participants diagnosed in recent years (2014 and later), reported that prior to TTTS diagnosis, they did not receive biweekly or more frequent ultrasounds. Three patient-reported provider practices were related to receiving ultrasounds at the recommended frequency: (1) determining MCDA status prior to gestational week 14, (2) providing participants with early warnings about the risk of TTTS to their pregnancies after MCDA status had been determined, and (3) referring participants to a Maternal-Fetal Medicine Specialist after MCDA identification, as validated by qualitative data. Our qualitative data revealed gaps in effective clinical care experiences among OB/GYN and specialist providers. CONCLUSION: These findings indicate screening and diagnosis for TTTS, as reported by patients, is improving in the United States; however, further efforts are required to ensure all patients receive appropriate screening, education and a team-based approach to comprehensive and supportive clinical care.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0200087" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0200087</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Adult
Aultman Julie
Baughman Kristin
College of Graduate Studies
College of Medicine
Cross-Sectional Studies
Department of Family & Community Medicine
Falletta Lynn
Female
Fetofetal Transfusion/*diagnosis/*diagnostic imaging/*epidemiology
Fischbein Rebecca
Gestational Age
Humans
NEOMED College of Graduate Studies
NEOMED College of Medicine
Nicholas Lauren
Patient Reported Outcome Measures
PloS one
Pregnancy
Prenatal Care/methods
Prenatal/methods
Retrospective Studies
Ultrasonography
Ultrasonography/methods
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1186/1465-9921-8-27" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/1465-9921-8-27</a>
Pages
27–27
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stimulation of MAP kinase pathways after maternal IL-1beta exposure induces fetal lung fluid absorption in guinea pigs.
Publisher
An entity responsible for making the resource available
Respiratory research
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-03
Subject
The topic of the resource
Absorption/drug effects; Animal/*metabolism; Animals; Body Fluids/*metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Fetus/metabolism; Gestational Age; Guinea Pigs; Hydrocortisone/*metabolism; Injections; Interleukin-1beta/administration & dosage/*pharmacology; Lung/*embryology; Mitogen-Activated Protein Kinase Kinases/metabolism; Mitogen-Activated Protein Kinases/*metabolism; Pregnancy; Rats; Recombinant Proteins/administration & dosage/pharmacology; Subcutaneous
Creator
An entity primarily responsible for making the resource
Bhattacharjee Reshma; Li Tianbo; Koshy Shyny; Beard LaMonta L; Sharma Kapil; Carter Ethan P; Garat Chrystelle; Folkesson Hans G
Description
An account of the resource
BACKGROUND: We tested the hypothesis that maternal interleukin-1beta (IL-1beta) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs. METHODS: IL-1beta was administered subcutaneously daily to timed-pregnant guinea pigs for three days. Fetuses were obtained by abdominal hysterotomy and instilled with isosmolar 5% albumin into the lungs and lung fluid movement was measured over 1 h by mass balance. MAP kinase expression was measured by western blot. RESULTS: Lung fluid absorption was induced at 61 days (D) gestation and stimulated at 68D gestation by IL-1beta. Maternal IL-1beta pretreatment upregulated ERK and upstream MEK expression at both 61 and 68D gestation, albeit being much more pronounced at 61D gestation. U0126 instillation completely blocked IL-1beta-induced lung fluid absorption as well as IL-1beta-induced/stimulated ERK expression. Cortisol synthesis inhibition by metyrapone attenuated ERK expression and lung fluid absorption in IL-1beta-pretreated fetal lungs. JNK expression after maternal
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1186/1465-9921-8-27" target="_blank" rel="noreferrer noopener">10.1186/1465-9921-8-27</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Absorption/drug effects
Animal/*metabolism
Animals
Beard LaMonta L
Bhattacharjee Reshma
Body Fluids/*metabolism
Carter Ethan P
Extracellular Signal-Regulated MAP Kinases/metabolism
Female
Fetus/metabolism
Folkesson Hans G
Garat Chrystelle
Gestational Age
Guinea Pigs
Hydrocortisone/*metabolism
Injections
Interleukin-1beta/administration & dosage/*pharmacology
Koshy Shyny
Li Tianbo
Lung/*embryology
Mitogen-Activated Protein Kinase Kinases/metabolism
Mitogen-Activated Protein Kinases/*metabolism
Pregnancy
Rats
Recombinant Proteins/administration & dosage/pharmacology
Respiratory research
Sharma Kapil
Subcutaneous
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00183.2001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00183.2001</a>
Pages
L508–515
Issue
3
Volume
282
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-03
Subject
The topic of the resource
Adrenergic beta-Antagonists/pharmacology; Aging/metabolism; Animals; Body Fluids/*metabolism; Body Water/metabolism; Catecholamines/*physiology; Embryonic and Fetal Development; Epinephrine/blood; Epithelium/metabolism; Female; Fetus/drug effects/metabolism; Gestational Age; Lung/drug effects/*embryology/metabolism; Male; Newborn/metabolism; Propranolol/pharmacology; Rats; Sprague-Dawley; Time Factors
Creator
An entity primarily responsible for making the resource
Folkesson Hans G; Matthay Michael A; Chapin Cheryl J; Porta Nicolas F M; Kitterman Joseph A
Description
An account of the resource
Knowledge about the conversion of the epithelium in the distal air spaces of the lung from secretion to absorption is imperative to the understanding of postnatal lung development; little such information is available in rats. Distal air space fluid clearance was therefore measured in 21- to 22-day gestation rat fetuses and newborn (40 h) rats. Distal air space fluid clearance was measured from the increase in (131)I-albumin concentration in an isosmolar, physiological solution instilled into the developing lungs. There was no net fluid movement across the distal air space epithelium in the lungs of 21-day gestation fetuses. Twenty-four hours later, distal air space fluid was cleared at a rapid rate in the 22-day gestation fetuses. Within the first 40 h after birth, the rate rapidly declined to adult levels. The high distal air space fluid clearance at 22 days gestation and at 40 h after birth was mediated by beta-adrenergic receptors as demonstrated by elevated plasma epinephrine levels and inhibition by propranolol. Interestingly, the elevated distal air space fluid clearance in the 22-day gestation fetuses was only minimally amiloride sensitive; however, amiloride sensitivity increased over the first 40 h after birth. In conclusion, these studies demonstrate that 1) rapid rates of net alveolar fluid clearance occur late in gestation in the rat and 2) this clearance is driven by elevations of endogenous epinephrine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00183.2001" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00183.2001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Adrenergic beta-Antagonists/pharmacology
Aging/metabolism
American journal of physiology. Lung cellular and molecular physiology
Animals
Body Fluids/*metabolism
Body Water/metabolism
Catecholamines/*physiology
Chapin Cheryl J
Embryonic and Fetal Development
Epinephrine/blood
Epithelium/metabolism
Female
Fetus/drug effects/metabolism
Folkesson Hans G
Gestational Age
Kitterman Joseph A
Lung/drug effects/*embryology/metabolism
Male
Matthay Michael A
Newborn/metabolism
Porta Nicolas F M
Propranolol/pharmacology
Rats
Sprague-Dawley
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jaapos.2016.07.229" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jaapos.2016.07.229</a>
Pages
537–539
Issue
6
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Postmortem vitreous bevacizumab levels of an infant treated for retinopathy of prematurity.
Publisher
An entity responsible for making the resource available
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-12
Subject
The topic of the resource
*Retinopathy of Prematurity; Angiogenesis Inhibitors; Antibodies; Bevacizumab/*analysis; Gestational Age; Humanized; Humans; Infant; Intravitreal Injections; Monoclonal; Newborn; Vascular Endothelial Growth Factor A; Vitreous Body/*chemistry
Creator
An entity primarily responsible for making the resource
Hypes Stephen; Nasser Orwa; Hanna Nancy; Lawhon William; Bouhenni Rachida; Hertle Richard W
Description
An account of the resource
We report the vitreous concentration of bevacizumab after injection for the treatment of retinopathy of prematurity (ROP). A premature neonate diagnosed with type 1 ROP was treated in both eyes with 0.625 mg intravitreal bevacizumab injection at 32 weeks' postconceptual age. Eleven weeks later there was complete regression clinically, but the patient died. Vitreous samples taken at autopsy revealed a bevacizumab vitreous concentration of 41.57 ng/ml. Histopathology of the retina showed residual preretinal neovascularization. Bevacizumab elimination from the infant vitreous is similar to that of adults, and, although complete regression was clinically apparent, it was not confirmed histopathologically.
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<a href="http://doi.org/10.1016/j.jaapos.2016.07.229" target="_blank" rel="noreferrer noopener">10.1016/j.jaapos.2016.07.229</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Retinopathy of Prematurity
2016
Angiogenesis Inhibitors
Antibodies
Bevacizumab/*analysis
Bouhenni Rachida
Department of Pharmaceutical Sciences
Gestational Age
Hanna Nancy
Hertle Richard W
Humanized
Humans
Hypes Stephen
Infant
Intravitreal Injections
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
Lawhon William
Monoclonal
Nasser Orwa
NEOMED College of Pharmacy
Newborn
Vascular Endothelial Growth Factor A
Vitreous Body/*chemistry
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.ajog.2003.09.074" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajog.2003.09.074</a>
Pages
340–345
Issue
1
Volume
191
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Stimulation of distal airspace fluid clearance in guinea pigs involves bumetanide-sensitive ion transport.
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American journal of obstetrics and gynecology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-07
Subject
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*Ion Transport; Absorption; Adrenergic; Adrenergic beta-Antagonists/pharmacology; Animals; beta/physiology; Body Fluids/*metabolism; Bumetanide/*pharmacology; Diuretics/*pharmacology; Epinephrine/blood; Epithelium; Fetus/metabolism; Gestational Age; Guinea Pigs; Lung/*embryology/metabolism; Newborn; Propranolol/pharmacology; Receptors
Creator
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Ye Xin; Norlin Andreas; Folkesson Hans G
Description
An account of the resource
OBJECTIVE: This study was undertaken to test the hypothesis that beta-adrenoceptor stimulation of fetal lung fluid absorption in near-term guinea pig fetuses involves bumetanide-sensitive ion transport. STUDY DESIGN: Fetuses were obtained from timed-pregnant guinea pigs at 61 to 69 days' gestation with and without oxytocin-induced preterm labor. The fetuses were placed on continuous positive airway pressure oxygenation, and an isosmolar 5% albumin solution was instilled into the lungs. Distal airspace fluid clearance was measured over 1 hour from the increase in distal airspace protein concentration as fluid was reabsorbed with and without the Cl(-) transport inhibitor bumetanide. RESULTS: Fetal lungs began to absorb distal airspace fluid at 64 to 66 days' gestation, and at birth, distal airspace fluid clearance rapidly quadrupled. Labor induction by oxytocin stimulated distal airspace fluid clearance. Distal airspace fluid clearance, when present, was sensitive to propranolol-inhibition and depended on beta-adrenoceptor stimulation. Fluid secretion at 61 days' gestation was reduced by bumetanide instillation. Bumetanide addition was only inhibitory when distal airspace fluid clearance was propranolol-sensitive. CONCLUSION: Beta-adrenoceptor stimulation from endogenous fetal epinephrine increased fetal distal airspace fluid clearance and involved bumetanide-sensitive ion transport.
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<a href="http://doi.org/10.1016/j.ajog.2003.09.074" target="_blank" rel="noreferrer noopener">10.1016/j.ajog.2003.09.074</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ion Transport
2004
Absorption
Adrenergic
Adrenergic beta-Antagonists/pharmacology
American journal of obstetrics and gynecology
Animals
beta/physiology
Body Fluids/*metabolism
Bumetanide/*pharmacology
Diuretics/*pharmacology
Epinephrine/blood
Epithelium
Fetus/metabolism
Folkesson Hans G
Gestational Age
Guinea Pigs
Lung/*embryology/metabolism
Newborn
Norlin Andreas
Propranolol/pharmacology
Receptors
Ye Xin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ar.21363" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ar.21363</a>
Pages
1461–1471
Issue
9
Volume
294
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Fetal lung epithelial ion channels relocate in the cell membrane during late gestation.
Publisher
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Anatomical record (Hoboken, N.J. : 2007)
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-09
Subject
The topic of the resource
Animals; Blotting; Caveolin 1/*metabolism; Cell Membrane/*metabolism; Cl transport; Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism; distal lung fluid absorption; Epithelial Sodium Channels/*metabolism; Epithelium/embryology/*metabolism; Female; fetal lung development; Fetus/*metabolism; Gestational Age; Guinea Pigs; IL-1beta; Immunoprecipitation; Interleukin-1beta/metabolism; Ion Channels/metabolism; Lung/embryology/*metabolism; Na transport; Western
Creator
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Beard LaMonta L; Li Tianbo; Hu Yang; Folkesson Hans G
Description
An account of the resource
Near the end of gestation, the direction of ion and fluid flow across the alveolar epithelium rapidly changes from secretion to absorption. Thus, the relative cell membrane location of epithelial Na channels (ENaCs) and cystic fibrosis transmembrane regulator (CFTR) Cl channels during late fetal lung development and after maternal interleukin-1beta (IL-1beta) pretreatment was the focus of our study. Western blot analysis after sucrose gradient separation of caveolin-1-(Cav-1)-rich membrane regions (CRR) and Cav-1-poor membrane (non-CRR) revealed primary CRR ENaC localization at gestation day (GD) 61 in guinea pigs. Correlating with the natural induction of distal lung fluid absorption, ENaC appeared in the non-CRR cell membrane regions at GD68. Conversely, CFTR was present in the non-CRR cell membrane regions at GD61 and in the CRRs at GD68.
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<a href="http://doi.org/10.1002/ar.21363" target="_blank" rel="noreferrer noopener">10.1002/ar.21363</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Anatomical record (Hoboken, N.J. : 2007)
Animals
Beard LaMonta L
Blotting
Caveolin 1/*metabolism
Cell Membrane/*metabolism
Cl transport
Cystic Fibrosis Transmembrane Conductance Regulator/*metabolism
distal lung fluid absorption
Epithelial Sodium Channels/*metabolism
Epithelium/embryology/*metabolism
Female
fetal lung development
Fetus/*metabolism
Folkesson Hans G
Gestational Age
Guinea Pigs
Hu Yang
IL-1beta
Immunoprecipitation
Interleukin-1beta/metabolism
Ion Channels/metabolism
Li Tianbo
Lung/embryology/*metabolism
Na transport
Western