Browse Items · NEOMED Bibliography Database

Ocular Hypertension Results in Hypoxia within Glia and Neurons throughout the Visual Projection

The magnitude and duration of hypoxia after ocular hypertension (OHT) has been a matter of debate due to the lack of tools to accurately report hypoxia. In this study, we established a topography of hypoxia in the visual pathway by inducing OHT in…

Tags: 2022, Astrocytes, Glaucoma, hypoxia, Microglia, Müller glia, Retinal Ganglion Cells

Oxidative Stress and Hypoxia Modify Mitochondrial Homeostasis During Glaucoma.

Aims: Cellular response to hypoxia can include transition from respiration to glycolysis via upregulation of glycolytic enzymes and transporters, as well as mitophagy induction to eliminate surplus mitochondria. Our purpose was to evaluate the impact…

Tags: 2021, Glaucoma, glycolysis, HIF-1α, hypoxia, Oxidative Stress, PGC-1α

Absence of cytochrome P450-1b1 increases susceptibility of pressure-induced axonopathy in the murine retinal projection.

Adult mixed sex Cyp1b1–/– [129S6.129 × 1(B6)-Cyp1b1TM1Gonz/Mmnc] mice were obtained from the Mutant Mouse Resource and Research Center (MMRRC) at JAX (Jackson Laboratories) and genotyped before experimentation to confirm the transgene. These mice…

Tags: 2021, axonal transport disruption, Glaucoma, microbead occlusion model, nodes of Ranvier, Retinal ganglion cell

Oxidative Stress and Hypoxia Modify Mitochondrial Homeostasis During Glaucoma.

Aims: Cellular response to hypoxia can include transition from respiration to glycolysis via upregulation of glycolytic enzymes and transporters, as well as mitophagy induction to eliminate surplus mitochondria. Our purpose was to evaluate…

Tags: 2021, Antioxidants & redox signaling, Department of Pharmaceutical Sciences, Fan Y, Glaucoma, glycolysis, HIF-1α, hypoxia, Inman DM, Jassim AH, journalArticle, May 2021 List, NEOMED College of Pharmacy Student, NEOMED Student Publications, Nsiah NY, Oxidative Stress, Pappenhagen N, PGC-1α

Absence of cytochrome P450-1b1 increases susceptibility of pressure-induced axonopathy in the murine retinal projection.

Mutations in the cytochrome P450-1B1 (Cyp1b1) gene is a common genetic predisposition associated with various human glaucomas, most prominently in primary congenital glaucoma (PCG). The role of Cyp1b1 in the eye is largely unknown, however, its…

Tags: 2021, Amirmokhtari N, April 2021 List, axonal transport disruption, Bouhenni RA, Department of Pharmaceutical Sciences, Dewan SS, Foresi BD, Frontiers In Cell And Developmental Biology, Glaucoma, journalArticle, microbead occlusion model, NEOMED College of Graduate Studies Student, NEOMED College of Pharmacy, NEOMED Student Publications, nodes of Ranvier, Retinal ganglion cell, Smith MA

Retinal ganglion cell loss and gliosis in the retinofugal projection following intravitreal exposure to amyloid-beta.

Pathological accumulations of amyloid-beta (Aβ) peptide are found in retina early in Alzheimer's disease, yet its effects on retinal neuronal structure remain unknown. To investigate this, we injected fibrillized Aβ(1-42) protein into the eye of…

Tags: 2020, Alzheimer's disease, amyloid-beta, CD36, Cluster of differentiation 36, Crish SD, Dengler-Crish C M, Glaucoma, Inflammation, journalArticle, NEOMED College of Graduate Studies Student, NEOMED Student Publications, Neurobiology of disease, October 2020 List, retina, Simons ES, Smith M A, superior colliculus

Transcorneal electrical stimulation reduces neurodegenerative process in a mouse model of glaucoma.

Glaucoma is a neurodegenerative disease in which the retinal ganglion cell axons of the optic nerve degenerate concomitant with synaptic changes in the retina, leading finally to death of the retinal ganglion cells (RGCs). Electrical stimulation has…

Tags: 2020, Annals Of Biomedical Engineering, BDNF, Cavanaugh M, Glaucoma, Hassan JA, Inman DM, journalArticle, NEOMED College of Medicine Student, NEOMED Student Publications, optic nerve, p75NTR, retina, September 2020 List, Shah JS, Transcorneal electrical stimulation, Willits R

The role of TRPV4 channels in ocular function and pathologies.

Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. TRPV4 is widely expressed throughout the body, and plays an…

MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma.

Improving cellular access to energy substrates is one strategy to overcome observed declines in energy production and utilization in the aged and pathologic central nervous system. Monocarboxylate transporters (MCTs), the movers of lactate, pyruvate,…

Tags: 2020, Coughlin Lucy, Department of Pharmaceutical Sciences, Glaucoma, Harun-Or-Rashid Mohammad, Inman Denise M, Jassim Assraa Hassan, journalArticle, June 2020 Update II, Metabolism, Monocarboxylate transporter, NEOMED College of Pharmacy Student, NEOMED Student Publications, Neurobiology of disease, Ocular Hypertension, Pappenhagen Nathaniel, Retinal ganglion cell, Zubricky Ryan

Current Management of Uveitis-associated Ocular Hypertension and Glaucoma

Glaucoma secondary to ocular inflammation is potentially blinding and requires aggressive multifaceted management. The pathogenesis is related to the intraocular pressure (IOP) elevation secondary to compromised aqueous humor outflow by inflammatory…

Tags: 2019, corticosteroid, Glaucoma, glaucoma surgery, intraocular pressure management, January 2020 Update, Journal Article, Kahook Malik Y, Kesav Natasha, NEOMED College of Medicine Student, NEOMED Student Publications, Ocular Hypertension, Palestine Alan G, Pantcheva Mina B, Survey of Ophthalmology, uveitis

Decreased Energy Capacity And Increased Autophagic Activity In Optic Nerve Axons With Defective Anterograde Transport

PURPOSE. Autophagy is a critical process, compromised in neurodegenerative disease, by which terminally differentiated cells like neurons manage cytoskeletal and organelle turnover. How autophagy relates to associated neurodegenerative pathologies…

Abnormal Metal Levels In The Primary Visual Pathway Of The Dba/2j Mouse Model Of Glaucoma

Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy

The p38 mitogen-activated protein kinase (MAPK) isoforms are phosphorylated by a variety of stress stimuli in neurodegenerative disease and act as upstream activators of myriad pathogenic processes. Thus, p38 MAPK inhibitors are of growing interest…

Suppression of transforming growth factor-beta effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor

Purpose: Transforming growth factor-beta (TGF-beta) activity has been implicated in subconjunctival scarring in eyes following glaucoma filtration surgery (GFS). The purpose of this study is to determine whether an inhibitor for activin receptor-like…

Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma

Background: Neuroinflammation-astrogliosis, microglial activation, and changes in cytokine signaling-is a prominent feature of neurodegenerative disorders. Glaucoma is a group of chronic neurodegenerative conditions that make up the leading cause of…

Bimatoprost - a review

Bimatoprost is a synthetic prostamide analog that is efficacious in the treatment of open-angle glaucoma, ocular hypertension and other forms of glaucoma. it reduces intraocular pressure (IOP) by increasing uveoscleral and trabecular outflow. When…

Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve.

Metabolic dysfunction accompanies neurodegenerative disease and aging. An important step for therapeutic development is a more sophisticated understanding of the source of metabolic dysfunction, as well as to distinguish disease-associated changes…

Tags: 2019, Chen Yeong-Renn, Coughlin Lucy, DBA/2J, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Fluorocitrate, Glaucoma, Harun-Or-Rashid Mohammad, Inman Denise M, Jassim Assraa Hassan, Kang Patrick T, Mitochondria, Molecular neurobiology, NEOMED College of Medicine, NEOMED College of Pharmacy, optic nerve, Seahorse analyzer

Editorial: Axonopathy in Neurodegenerative Disease.

Tags: 2018, axon degeneration, Burgess Robert W, chemotherapy induced neuropathy, Crish Samuel D, Department of Pharmaceutical Sciences, Frontiers in neuroscience, Glaucoma, mitochondrial dysfuncion, NEOMED College of Pharmacy, Neuropathy

Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma.

Axonal transport deficits precede structural loss in glaucoma and other neurodegenerations. Impairments in structural support, including modified cytoskeletal proteins, and microtubule-destabilizing elements, could be initiating factors in glaucoma…

Tags: 2016, amyloid-beta, Axonal Transport, Crish Samuel D, cytoskeleton, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Frontiers in neuroscience, Glaucoma, Inman Denise M, NEOMED College of Pharmacy, neurofilament, Phosphorylation, Smith Matthew A, spectrin, Tau, Wilson Gina N

Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma.

Axonal transport deficits have been reported as an early pathology in several neurodegenerative disorders, including glaucoma. However, the progression and mechanisms of these deficits are poorly understood. Previous work suggests that anterograde…

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.

BACKGROUND: Glaucoma is a chronic degenerative disease for which inflammation is considered to play a pivotal role in the pathogenesis and progression. In this study, we examined the impact of a ketogenic diet on the inflammation evident in glaucoma…

Tags: 2018, AMP-activated protein kinase, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cells – Drug Effects, Cells – Pathology, Department of Pharmaceutical Sciences, Diet, Disease Models, Eye Proteins/genetics, Female, G-Protein-Coupled – Metabolism, G-Protein-Coupled/*metabolism, Glaucoma, Glaucoma – Complications, Glaucoma – Pathology, Glaucoma/*complications/pathology, Harun-Or-Rashid Mohammad, Impact of Events Scale, Inbred DBA, Inflammation – Etiology, Inflammation – Prevention and Control, Inflammation hydroxycarboxylic acid receptor, Inflammation/*etiology/*prevention & control, Inman Denise M, Journal of neuroinflammation, Ketogenic diet, Ketogenic/methods, Male, Membrane Glycoproteins, Membrane Glycoproteins/genetics, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia/drug effects/pathology, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Neuroprotection/drug effects/*physiology, NLR Family, Optic Nerve – Pathology, Optic Nerve/pathology, Phosphotransferases – Metabolism, Proteins, Pyrin Domain-Containing 3 Protein/genetics/metabolism, Receptors, Retina – Drug Effects, Retina – Pathology, Retinal Ganglion Cells/drug effects/*pathology, Transgenic

Common eye disorders: six patients to refer.

Thorough ocular history taking and physical examination are essential to establish a diagnosis in patients presenting with eye conditions. Some conditions require ophthalmologic referral to avoid serious complications and even vision loss. These…

Tags: 1996, Adult, Aged, Angle-Closure/diagnosis/therapy, Corneal Ulcer/diagnosis/therapy, Eye Diseases/*diagnosis/*therapy, Female, Glaucoma, Humans, Iritis/diagnosis/therapy, Male, Postgraduate medicine, Referral and Consultation, Retinal Artery Occlusion/diagnosis/therapy, Retinal Detachment/diagnosis/therapy, Weinstock F J, Weinstock M B

Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma.

Glaucoma challenges the survival of retinal ganglion cell axons in the optic nerve through processes dependent on both aging and ocular pressure. Relevant stressors likely include complex interplay between axons and astrocytes, both in the retina and…

Browse Items (23 total)