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Text
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URL Address
<a href="http://doi.org/10.1074/jbc.M117.784322" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.M117.784322</a>
Pages
11055–11069
Issue
26
Volume
292
Dublin Core
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Title
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Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
Publisher
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The Journal of biological chemistry
Date
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2017
2017-06
Subject
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*bile acid; *bile acid metabolism; *FXR; *Gene Expression Regulation; *GLP-1; *lipid metabolism; *liver metabolism; *non-alcoholic fatty liver disease; *obesity; *TGR5; *type 2 diabetes; Animals; Bile Acids and Salts/*biosynthesis/genetics; Cytoplasmic and Nuclear/genetics/*metabolism; Dietary Fats; G-Protein-Coupled/genetics/*metabolism; Glucagon-Like Peptide 1/genetics/metabolism; Glucose/metabolism; Knockout; Lipid Metabolism; Liver/*metabolism; Mice; Obesity/genetics/*metabolism/pathology; Receptors
Creator
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Pathak Preeti; Liu Hailiang; Boehme Shannon; Xie Cen; Krausz Kristopher W; Gonzalez Frank; Chiang John Y L
Description
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The bile acid-activated receptors, nuclear farnesoid X receptor (FXR) and the membrane Takeda G-protein receptor 5 (TGR5), are known to improve glucose and insulin sensitivity in obese and diabetic mice. However, the metabolic roles of these two receptors and the underlying mechanisms are incompletely understood. Here, we studied the effects of the dual FXR and TGR5 agonist INT-767 on hepatic bile acid synthesis and intestinal secretion of glucagon-like peptide-1 (GLP-1) in wild-type, Fxr(-/-), and Tgr5(-/-) mice. INT-767 efficaciously stimulated intracellular Ca(2+) levels, cAMP activity, and GLP-1 secretion and improved glucose and lipid metabolism more than did the FXR-selective obeticholic acid and
Identifier
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<a href="http://doi.org/10.1074/jbc.M117.784322" target="_blank" rel="noreferrer noopener">10.1074/jbc.M117.784322</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*bile acid
*bile acid metabolism
*FXR
*Gene Expression Regulation
*GLP-1
*Lipid Metabolism
*liver metabolism
*Non-alcoholic Fatty Liver Disease
*Obesity
*TGR5
*type 2 diabetes
2017
Animals
Bile Acids and Salts/*biosynthesis/genetics
Boehme Shannon
Chiang John Y L
Cytoplasmic and Nuclear/genetics/*metabolism
Department of Integrative Medical Sciences
Dietary Fats
G-Protein-Coupled/genetics/*metabolism
Glucagon-Like Peptide 1/genetics/metabolism
Glucose/metabolism
Gonzalez Frank
Knockout
Krausz Kristopher W
Lipid Metabolism
Liu Hailiang
Liver/*metabolism
Mice
NEOMED College of Medicine
Obesity/genetics/*metabolism/pathology
Pathak Preeti
Receptors
The Journal of biological chemistry
Xie Cen