1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpcell.00256.2014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpcell.00256.2014</a>
Pages
C111–122
Issue
2
Volume
308
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Trivalent chromium inhibits TSP-1 expression, proliferation, and O-GlcNAc signaling in vascular smooth muscle cells in response to high glucose in vitro.
Publisher
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American journal of physiology. Cell physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-01
Subject
The topic of the resource
Aorta/drug effects/metabolism; Cell Proliferation/*drug effects/genetics; Cells; Chromium/*pharmacology; Cultured; Fructosephosphates/metabolism; Genetic/drug effects/genetics; Glucose/*metabolism; Glutamine/genetics; Glycosylation/drug effects; Hexosamines/metabolism; Humans; Hyperglycemia/metabolism; Muscle; Myocytes; N-Acetylglucosaminyltransferases/genetics; O-glycosylation; Promoter Regions; reactive oxygen species; Reactive Oxygen Species/metabolism; Signal Transduction/*drug effects/genetics; Smooth; Smooth Muscle/*drug effects/metabolism; Thrombospondin 1/*antagonists & inhibitors/genetics; thrombospondin-1; Transcription; trivalent chromium; vascular smooth muscle cells; Vascular/*drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Ganguly Rituparna; Sahu Soumyadip; Chavez Ronaldo J; Raman Priya
Description
An account of the resource
Trivalent chromium (Cr(3+)) is a mineral nutrient reported to have beneficial effects in glycemic and cardiovascular health. In vitro and in vivo studies suggest that Cr(3+) supplementation reduces the atherogenic potential and lowers the risk of vascular inflammation in diabetes. However, effects of Cr(3+) in vascular cells under conditions of hyperglycemia, characteristic of diabetes, remain unknown. In the present study we show that a therapeutically relevant concentration of Cr(3+) (100 nM) significantly downregulates a potent proatherogenic matricellular protein, thrombospondin-1 (TSP-1), in human aortic smooth muscle cells (HASMC) stimulated with high glucose in vitro. Promoter-reporter assays reveal that this downregulation of TSP-1 expression by Cr(3+) occurs at the level of transcription. The inhibitory effects of Cr(3+) on
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpcell.00256.2014" target="_blank" rel="noreferrer noopener">10.1152/ajpcell.00256.2014</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
American journal of physiology. Cell physiology
Aorta/drug effects/metabolism
Cell Proliferation/*drug effects/genetics
Cells
Chavez Ronaldo J
Chromium/*pharmacology
Cultured
Department of Integrative Medical Sciences
Fructosephosphates/metabolism
Ganguly Rituparna
Genetic/drug effects/genetics
Glucose/*metabolism
Glutamine/genetics
Glycosylation/drug effects
Hexosamines/metabolism
Humans
Hyperglycemia/metabolism
Muscle
Myocytes
N-Acetylglucosaminyltransferases/genetics
NEOMED College of Medicine
O-glycosylation
Promoter Regions
Raman Priya
reactive oxygen species
Reactive Oxygen Species/metabolism
Sahu Soumyadip
Signal Transduction/*drug effects/genetics
Smooth
Smooth Muscle/*drug effects/metabolism
Thrombospondin 1/*antagonists & inhibitors/genetics
thrombospondin-1
Transcription
trivalent chromium
vascular smooth muscle cells
Vascular/*drug effects/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/S1084-2756(03)00113-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/S1084-2756(03)00113-1</a>
Pages
37–47
Issue
1
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Selected principles of perinatal-neonatal glucose metabolism.
Publisher
An entity responsible for making the resource available
Seminars in neonatology : SN
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-02
Subject
The topic of the resource
Blood Glucose/metabolism; Female; Fetus/*metabolism; Glucose/*metabolism; Humans; Hyperglycemia/embryology/physiopathology; Hypoglycemia/embryology/physiopathology; Infant; Liver/*embryology/*metabolism; Newborn/*metabolism; Pregnancy
Creator
An entity primarily responsible for making the resource
Cowett Richard M; Farrag Hussien M
Description
An account of the resource
While the fetus is completely dependent on his/her mother for glucose and other nutrient transfer across the placenta, the adult is completely independent, especially one who is neither pregnant nor diabetic. The neonate is considered to be in a transition between the complete dependence of the fetus and the complete independence of the adult. The heterogeneity that is the hallmark of neonatal glucose metabolism is illustrated by the observation that maintenance of euglycaemia in the sick and/or low-birthweight neonate is especially difficult. This reinforces the concept that the neonate is vulnerable to carbohydrate disequilibrium. In this discussion, we shall first evaluate the definition of euglycaemia by considering the ranges for hypo- and hyperglycaemia. We shall also review the considerable literature that has been published on measurement of the rate of glucose production and the rate of glucose utilization in the neonate. This review highlights where further work is necessary to understand the developing maturation (i.e. control) of glucose homeostasis in the neonate.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/S1084-2756(03)00113-1" target="_blank" rel="noreferrer noopener">10.1016/S1084-2756(03)00113-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Blood Glucose/metabolism
Cowett Richard M
Farrag Hussien M
Female
Fetus/*metabolism
Glucose/*metabolism
Humans
Hyperglycemia/embryology/physiopathology
Hypoglycemia/embryology/physiopathology
Infant
Liver/*embryology/*metabolism
Newborn/*metabolism
Pregnancy
Seminars in neonatology : SN