1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2741/1591" target="_blank" rel="noreferrer noopener">http://doi.org/10.2741/1591</a>
Pages
966–974
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ligand epitope antigen presentation system vaccines against herpes simplex virus.
Publisher
An entity responsible for making the resource available
Frontiers in bioscience : a journal and virtual library
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-01
Subject
The topic of the resource
Humans; Animals; Mice; Ligands; *Antigen Presentation; *Cancer Vaccines; *Epitopes; Glycoproteins/chemistry; Immediate-Early Proteins/chemistry; Simplexvirus/*metabolism; Herpesvirus 1; Human/metabolism
Creator
An entity primarily responsible for making the resource
Goel Neena; Zimmerman Daniel H; Rosenthal Kenneth S
Description
An account of the resource
The Ligand Epitope Antigen Presentation System (L.E.A.P.S.) approach to vaccine development allowed construction of immunogens from defined T cell epitopes from herpes simplex virus (HSV) proteins that conferred protection against lethal challenge by the virus. This technology utilizes specific peptides which bind to CD4, CD8 or other proteins on the surface of T cells (T cell binding ligand (TCBL)), macrophage and dendritic cells (immune cell binding ligand (ICBL)) to promote the immunogenicity of an epitope, activate T cell and other protective responses, and direct the immune response to either a Th1 or a Th2 type of response. The J TCBL/ICBL is a peptide from beta-2-microglobulin which binds to the CD8 protein and promotes Th1 responses and the G TCBL/ICBL is a peptide from the beta chain of MHC II molecules that binds to the CD4 protein and promotes Th2 responses. Epitopes from the ICP27 (H1, H2), glycoprotein B (gB) and glycoprotein D (gD) proteins of HSV-1 were attached to either the J TCBL/ICBL or the G TCBL/ICBL. The JH1, JH2, JgB and JgD vaccines elicited DTH responses without antibody but conferred protection upon lethal challenge. Th1 related antibody was produced after challenge of the JgB and JgD immunized mice. Immunization with the GH1, GgB or GgD vaccines did not yield protection. The GgB and GgD produced Th2 related antibodies upon virus challenge. Initiation of the immune response by the JgD vaccine was dependent on functional CD4, CD8 expressing cells and interferon gamma and delivery of protection was dependent upon CD4 and interferon gamma. The L.E.A.P.S. HSV vaccines appear to elicit the appropriate immune responses for protection and further work is being performed to develop the JgD vaccine for human use.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2741/1591" target="_blank" rel="noreferrer noopener">10.2741/1591</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Antigen Presentation
*Cancer Vaccines
*Epitopes
2005
Animals
Frontiers in bioscience : a journal and virtual library
Glycoproteins/chemistry
Goel Neena
Herpesvirus 1
Human/metabolism
Humans
Immediate-Early Proteins/chemistry
Ligands
Mice
Rosenthal Kenneth S
Simplexvirus/*metabolism
Zimmerman Daniel H