1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-0270(93)90086-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-0270(93)90086-7</a>
Pages
235–246
Issue
3
Volume
47
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/analysis; Amphetamine/pharmacology; Animals; Ascorbic Acid/analysis; Cerebral Cortex/drug effects/metabolism/*physiology; Dopamine/*analysis/metabolism; Electric Stimulation/instrumentation/methods; Electrochemistry/instrumentation/methods; Electrophysiology/instrumentation/*methods; Extracellular Space/chemistry; Hydroxyindoleacetic Acid/analysis; Male; Rats; Serotonin/analysis; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Description
An account of the resource
A technique is described for measuring electrophysiological multiple-unit activity and extracellular dopamine concentration with in vivo voltammetry at an array of 8 electrodes. In addition, new procedures in the construction of the voltammetric electrode that reduce the effects of capacitance and improve sensitivity are outlined. A system of relays controlling the connections of the electrode and associated systems is also detailed. Both in vitro and in vivo voltammetric selectivity tests indicate an almost exclusive response to dopamine. A large increase in extracellular dopamine concentration was detected in response to 2.5 mg/kg D-amphetamine. Both prestimulus and cortical stimulation evoked increases in striatal multiple-unit activity were measured.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-0270(93)90086-7" target="_blank" rel="noreferrer noopener">10.1016/0165-0270(93)90086-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
3
4-Dihydroxyphenylacetic Acid/analysis
Amphetamine/pharmacology
Animals
Ascorbic Acid/analysis
Cerebral Cortex/drug effects/metabolism/*physiology
Dopamine/*analysis/metabolism
Electric Stimulation/instrumentation/methods
Electrochemistry/instrumentation/methods
Electrophysiology/instrumentation/*methods
Extracellular Space/chemistry
Glynn G E
Hydroxyindoleacetic Acid/analysis
Journal of neuroscience methods
Male
Rats
Serotonin/analysis
Sprague-Dawley
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(89)90799-3</a>
Pages
235–241
Issue
2
Volume
481
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-03
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Indoles/*pharmacology; Nomifensine/*pharmacology; Homovanillic Acid/metabolism; Electrochemistry; Caudate Nucleus/drug effects/*metabolism; Mazindol/*pharmacology; Neurotransmitter Uptake Inhibitors/*pharmacology; Putamen/drug effects/*metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Description
An account of the resource
The neurochemical and anatomical heterogeneity of dopamine uptake blockade was studied at a medial and lateral position in each of 3 rostrocaudal areas of the rat caudate-putamen. In vivo voltammetric measures of extracellular dopamine indicated a lateral-to-medial and rostral-to-caudal gradient in the effect of uptake blockade. The percentage increase in dopamine was greatest in the rostrolateral area (300%) and least in the caudomedial area (10%). The existence of these lateromedial and rostrocaudal gradients was confirmed by tissue content measures of DOPAC and dopamine to DOPAC ratios in each area. The rostrocaudal gradient in the effect of uptake blockade was independent of the rostrocaudal gradient in dopamine tissue content. The regional gradients detected in dopamine uptake blockade may indicate a heterogeneous distribution in the number of uptake sites, a regional variation in the affinity of the uptake site for the blocker and/or altered neuronal activity mediated by an action of the blocker on dopaminergic cell bodies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(89)90799-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Caudate Nucleus/drug effects/*metabolism
Dopamine/*metabolism
Electrochemistry
Glynn G E
Homovanillic Acid/metabolism
Inbred Strains
Indoles/*pharmacology
Male
Mazindol/*pharmacology
Neurotransmitter Uptake Inhibitors/*pharmacology
Nomifensine/*pharmacology
Putamen/drug effects/*metabolism
Rats
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(89)90799-3</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
235-241
Issue
2
Volume
481
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Invivo Neurochemical And Anatomical Heterogeneity Of The Dopamine Uptake System In The Rat Caudate Putamen
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-03
Subject
The topic of the resource
Neurosciences & Neurology
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(89)90799-3</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1989
Brain research
Glynn G E
Neurosciences & Neurology
Yamamoto B K