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Text
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URL Address
<a href="http://doi.org/10.1002/dvdy.10066" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/dvdy.10066</a>
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Pages
389-401
Issue
3
Volume
223
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Title
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Formation Of Supernumerary Muscle Spindles At The Expense Of Golgi Tendon Organs In Er81-deficient Mice
Publisher
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Developmental Dynamics
Date
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2002
2002-03
Subject
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Anatomy & Morphology; Developmental Biology; ETS transcription factors; expression; Golgi tendon organs; group; ia afferents; innervation; motor neurons; muscle spindles; mutant mice; myosin heavy-chain; neonatal rats; nerve growth-factor; neurotrophin-3; primary sensory neurons; proprioceptive afferents; transcription factors
Creator
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Kucera J; Cooney W; Que A; Szeder V; Stancz-Szeder H; Walro J
Description
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ER81, a member of the ETS family of transcription factors, is essential for the formation of connections between sensory and motor neurons in the spinal cord. Mice lacking Er81 genes exhibit reduced monosynaptic sensory-motoneuron connectivity in response to muscle nerve stimulation. Proximal muscle nerve stimulation elicits fewer monosynaptic potentials than stimulation of distal nerves in hind-limbs, a deficit that is paralleled by a paucity of muscle spindles in proximal muscles (Arber et al., 2000). We examined whether a presence of spindles innervated by afferents in distal muscles correlated with the increased preservation of monosynaptic sensory-motor potentials in distal muscle nerves. Not only were spindles and Ia afferents present, but also they were supernumerary in distal muscles such as the soleus, medial gastrocnemius, and extensor hallucis longus. Concomitantly, a deficiency of Golgi tendon organs (GTOs) and Ib afferents was observed in distal muscles, as if supernumerary spindles formed at the expense of tendon organs in the absence of Er81. Thus, ER81 may be involved in mechanisms that regulate acquisition of the Ia and Ib phenotypes by subsets of proprioceptive muscle afferents. Segmental differences in muscle spindle and GTO dependence on ER81 suggest that more than one ETS transcription factor may participate in the regulation of limb proprioceptive system assembly in the mouse. (C) 2002 Wiley-Liss, Inc.
Identifier
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<a href="http://doi.org/10.1002/dvdy.10066" target="_blank" rel="noreferrer noopener">10.1002/dvdy.10066</a>
Format
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Journal Article or Conference Abstract Publication
2002
Anatomy & Morphology
Cooney W
Developmental Biology
Developmental Dynamics
ETS transcription factors
expression
Golgi tendon organs
group
ia afferents
innervation
Journal Article or Conference Abstract Publication
Kucera J
motor neurons
muscle spindles
mutant mice
myosin heavy-chain
neonatal rats
nerve growth-factor
neurotrophin-3
primary sensory neurons
proprioceptive afferents
Que A
Stancz-Szeder H
Szeder V
Transcription Factors
Walro J