Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease.
Female; Humans; Male; Middle Aged; Cardiovascular disease; Function; *Osteoarthritis; Aged; Incidence; Cohort Studies; Risk Factors; Exercise/*physiology; Cardiovascular Diseases/diagnosis/*epidemiology/physiopathology; Health Surveys/methods/trends; Independent Living/trends; North Carolina/epidemiology; Walk Test/methods/trends; Knee/diagnosis/*epidemiology/physiopathology
BACKGROUND: Osteoarthritis (OA) is associated with worsening physical function and a high prevalence of comorbid health conditions. In particular, cardiovascular disease (CVD) risk is higher in individuals with OA than the general population. Limitations in physical function may be one pathway to the development of CVD among individuals with OA. This study evaluated associations of symptomatic knee OA (sxKOA), baseline physical function and worsening of function over time with self-reported incident CVD in a community-based cohort. METHODS: Our sample consisted of individuals from the Johnston County Osteoarthritis Project who did not report having CVD at baseline. Variables used to evaluate physical function were the Health Assessment Questionnaire (HAQ), time to complete 5 chair stands, and the 8-ft walk. Worsening function for these variables was defined based on previous literature and cutoffs from our sample. Logistic regression analyses examined associations of sxKOA, baseline function and worsening of function over time with self-reported incident CVD, unadjusted and adjusted for relevant demographic and clinical characteristics. RESULTS: Among 1709 participants included in these analyses, the mean age was 59.5 +/- 9.5 years, 63.6% were women, 15% had sxKOA, and the follow up time was 5.9 +/- 1.2 years. About a third of participants reported worsening HAQ score, about two-fifths had worsened chair stand time, half had worsened walking speed during the 8-ft walk, and 16% self-reported incident CVD. In unadjusted analyses, sxKOA, baseline function, and worsening function were all associated with self-reported incident CVD. In multivariable models including all of these variables, sxKOA was not associated with incident CVD, but worsening function was significantly associated with increased CVD risk, for all three functional measures: HAQ odds ratio (OR) = 2.49 (95% confidence interval (CI) 1.90-3.25), chair stands OR = 1.58 (95% CI 1.20-2.08), 8-ft walk OR = 1.53 (95%CI 1.15-2.04). These associations for worsening function remained in models additionally adjusted for demographic and clinical characteristics related to CVD risk. CONCLUSIONS: The association between symptomatic knee osteoarthritis and cardiovascular disease risk was explained by measures of physical function. This highlights the importance of physical activity and other strategies to prevent functional loss among individuals with symptomatic knee osteoarthritis.
Corsi Michela; Alvarez Carolina; Callahan Leigh F; Cleveland Rebecca J; Golightly Yvonne M; Jordan Joanne M; Nelson Amanda E; Renner Jordan; Tsai Allen; Allen Kelli D
BMC musculoskeletal disorders
2018
2018-11
<a href="http://doi.org/10.1186/s12891-018-2311-4" target="_blank" rel="noreferrer noopener">10.1186/s12891-018-2311-4</a>
Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.
Adult; Female; Humans; Male; Middle Aged; Aged; Cross-Sectional Studies; Severity of Illness Index; Biomarkers/blood; Radiography; Human; Cross Sectional Studies; Middle Age; Arthralgia/*diagnostic imaging/*metabolism/physiopathology; BIOMARKERS; Carpometacarpal Joints/diagnostic imaging/metabolism/physiopathology; Finger Joint/diagnostic imaging/metabolism/physiopathology; HAND JOINTS; Hand Joints/*diagnostic imaging/*metabolism/physiopathology; Metacarpophalangeal Joint/diagnostic imaging/metabolism/physiopathology; OSTEOARTHRITIS; Osteoarthritis/*diagnostic imaging/*metabolism/physiopathology; RADIOGRAPHY; Severity of Illness Indices; Osteoarthritis – Physiopathology; Biological Markers – Blood; Arthralgia – Metabolism; Arthralgia – Physiopathology; Arthralgia – Radiography; Carpometacarpal Joints – Metabolism; Carpometacarpal Joints – Physiopathology; Carpometacarpal Joints – Radiography; Finger Joint – Metabolism; Finger Joint – Physiopathology; Finger Joint – Radiography; Hand Joints – Metabolism; Hand Joints – Physiopathology; Hand Joints – Radiography; Metacarpophalangeal Joint – Metabolism; Metacarpophalangeal Joint – Physiopathology; Metacarpophalangeal Joint – Radiography; Osteoarthritis – Metabolism; Osteoarthritis – Radiography
OBJECTIVE: To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade \textgreater/= 2], symptoms, and function. METHODS: Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure involving at least 3 hand joints distributed bilaterally with 2 of 3 in the same joint group, including \textgreater/= 1 distal interphalangeal joint, without metacarpophalangeal (MCP) swelling; (2) rOA in at least 1 joint of a group; and (3) number of joints with KL \textgreater/= 2. We assessed hand symptoms and the 15-item Australian Canadian Hand Osteoarthritis Index (AUSCAN; Likert format). We measured serum cartilage oligomeric matrix protein (sCOMP), hyaluronic acid (sHA), carboxy-terminal propeptide of type II collagen, type II collagen degradation product, urinary C-terminal crosslinked telopeptide of type II collagen, and urinary N-terminal crosslinked telopeptide. Linear regression models were performed to assess associations between each biomarker with hand rOA, AUSCAN, and symptoms, adjusting for age, sex, race, current smoking/drinking status, body mass index, and hip and knee rOA. RESULTS: In adjusted analyses, MCP (p \textless 0.0001) and carpometacarpal rOA (p = 0.003), and a higher number of hand joints with rOA (p = 0.009), were associated with higher levels of sHA. Positive associations were seen between AUSCAN and hand symptoms and levels of sCOMP (p
Aslam Imran; Perjar Irina; Shi Xiaoyan A; Renner Jordan B; Kraus Virginia B; Golightly Yvonne M; Jordan Joanne M; Nelson Amanda E
The Journal of rheumatology
2014
2014-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.3899/jrheum.130904" target="_blank" rel="noreferrer noopener">10.3899/jrheum.130904</a>
Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease.
Cardiovascular disease; Function; Osteoarthritis
BACKGROUND: Osteoarthritis (OA) is associated with worsening physical function and a high prevalence of comorbid health conditions. In particular, cardiovascular disease (CVD) risk is higher in individuals with OA than the general population. Limitations in physical function may be one pathway to the development of CVD among individuals with OA. This study evaluated associations of symptomatic knee OA (sxKOA), baseline physical function and worsening of function over time with self-reported incident CVD in a community-based cohort. METHODS: Our sample consisted of individuals from the Johnston County Osteoarthritis Project who did not report having CVD at baseline. Variables used to evaluate physical function were the Health Assessment Questionnaire (HAQ), time to complete 5 chair stands, and the 8-ft walk. Worsening function for these variables was defined based on previous literature and cutoffs from our sample. Logistic regression analyses examined associations of sxKOA, baseline function and worsening of function over time with self-reported incident CVD, unadjusted and adjusted for relevant demographic and clinical characteristics. RESULTS: Among 1709 participants included in these analyses, the mean age was 59.5 +/- 9.5 years, 63.6% were women, 15% had sxKOA, and the follow up time was 5.9 +/- 1.2 years. About a third of participants reported worsening HAQ score, about two-fifths had worsened chair stand time, half had worsened walking speed during the 8-ft walk, and 16% self-reported incident CVD. In unadjusted analyses, sxKOA, baseline function, and worsening function were all associated with self-reported incident CVD. In multivariable models including all of these variables, sxKOA was not associated with incident CVD, but worsening function was significantly associated with increased CVD risk, for all three functional measures: HAQ odds ratio (OR) = 2.49 (95% confidence interval (CI) 1.90-3.25), chair stands OR = 1.58 (95% CI 1.20-2.08), 8-ft walk OR = 1.53 (95%CI 1.15-2.04). These associations for worsening function remained in models additionally adjusted for demographic and clinical characteristics related to CVD risk. CONCLUSIONS: The association between symptomatic knee osteoarthritis and cardiovascular disease risk was explained by measures of physical function. This highlights the importance of physical activity and other strategies to prevent functional loss among individuals with symptomatic knee osteoarthritis.
Corsi Michela; Alvarez Carolina; Callahan Leigh F; Cleveland Rebecca J; Golightly Yvonne M; Jordan Joanne M; Nelson Amanda E; Renner Jordan; Tsai Allen; Allen Kelli D
BMC musculoskeletal disorders
2018
2018-11
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1186/s12891-018-2311-4" target="_blank" rel="noreferrer noopener">10.1186/s12891-018-2311-4</a>