1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.biopsych.2004.06.023" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.biopsych.2004.06.023</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
301-307
Issue
5
Volume
56
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Approaching A Consensus Cognitive Battery For Clinical Trials In Schizophrenia: The Nimh-matrics Conference To Select Cognitive Domains And Test Criteria
Publisher
An entity responsible for making the resource available
Biological Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-09
Subject
The topic of the resource
cognition; cognitive assessment; cognitive enhancement; impairment; memory; neural basis; neurocognition; neurocognitive deficits; neuroleptic-naive; neuropsychological function; Neurosciences & Neurology; performance; Psychiatry; psychopharmacology; risperidone; schizophrenia; siblings; thought-disorder
Creator
An entity primarily responsible for making the resource
Green M F; Nuechterlein K H; Gold J M; Barch D M; Cohen J; Essock S; Fenton W S; Frese F; Goldberg T E; Heaton R K; Keefe R S E; Kern R S; Kraemer H; Stover E; Weinberger D R; Zalcman S; Marder S R
Description
An account of the resource
To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) establisbed the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference . The goals of the meeting were to 1) the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria, for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literatum and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory. Reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizopbrenia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.biopsych.2004.06.023" target="_blank" rel="noreferrer noopener">10.1016/j.biopsych.2004.06.023</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
Barch D M
Biological psychiatry
Cognition
cognitive assessment
cognitive enhancement
Cohen J
Essock S
Fenton W S
Frese F
Gold J M
Goldberg T E
Green M F
Heaton R K
impairment
Journal Article or Conference Abstract Publication
Keefe R S E
Kern R S
Kraemer H
Marder S R
Memory
neural basis
neurocognition
neurocognitive deficits
neuroleptic-naive
neuropsychological function
Neurosciences & Neurology
Nuechterlein K H
Performance
Psychiatry
Psychopharmacology
risperidone
Schizophrenia
siblings
Stover E
thought-disorder
Weinberger D R
Zalcman S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1176/appi.ajp.2010.10030414" target="_blank" rel="noreferrer noopener">http://doi.org/10.1176/appi.ajp.2010.10030414</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
400-407
Issue
4
Volume
168
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evaluation Of Functionally Meaningful Measures For Clinical Trials Of Cognition Enhancement In Schizophrenia
Publisher
An entity responsible for making the resource available
American Journal of Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
battery; matrics; Psychiatry; reliability; scale; standardization; validity
Creator
An entity primarily responsible for making the resource
Green M F; Schooler N R; Kern R S; Frese F J; Granberry W; Harvey P D; Karson C N; Peters R N N; Stewart M; Seidman L J; Sonnenberg J; Stone W S; Walling D; Stover E; Marder S R
Description
An account of the resource
Objective: Because reduction of psychotic symptoms in schizophrenia does not result in adequate community functioning, efforts have shifted to other areas, such as cognitive impairment. The U. S. Food and Drug Administration requires that drugs for cognition enhancement in schizophrenia show improvement on two distinct outcome measures in clinical trials: an accepted cognitive performance battery and a functionally meaningful coprimary measure. The authors examined the reliability, validity, and practicality of functionally meaningful measures. Method: In this four-site validation study, schizophrenia patients were assessed at baseline (N= 166) and 4 weeks later (N= 144) on performance-based (Independent Living Scales, Test of Adaptive Behavior in Schizophrenia [TABS], and UCSD Performance-based Skills Assessment [UPSA]) and interview-based (Cognitive Assessment Interview and Clinical Global Impression Scale for Cognition) candidate coprimary measures. In addition, cognitive performance, community functioning, and clinical symptoms were assessed. Both full and short forms of the performance-based measures were evaluated. Results: All measures were well tolerated by patients, had adequate test-retest reliability, and showed good utility as a repeated measure. Measures differed in their correlation with cognitive performance, with performance-based measures having stronger correlations than interview-based measures. None of the measures had notable floor or ceiling effects or missing data. Conclusions: Among the full-form measures, the UPSA was judged to have the strongest overall properties. Among the short forms, the TABS and UPSA appeared to have the strongest features. Use of the short forms saves time, but at the cost of lower test-retest reliability and weaker correlations with cognitive performance.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1176/appi.ajp.2010.10030414" target="_blank" rel="noreferrer noopener">10.1176/appi.ajp.2010.10030414</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
American Journal of Psychiatry
battery
Frese F J
Granberry W
Green M F
Harvey P D
Journal Article or Conference Abstract Publication
Karson C N
Kern R S
Marder S R
matrics
Peters R N N
Psychiatry
reliability
scale
Schooler N R
Seidman L J
Sonnenberg J
standardization
Stewart M
Stone W S
Stover E
Validity
Walling D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1176/appi.ajp.2007.07010042" target="_blank" rel="noreferrer noopener">http://doi.org/10.1176/appi.ajp.2007.07010042</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
203-213
Issue
2
Volume
165
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity
Publisher
An entity responsible for making the resource available
American Journal of Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-02
Subject
The topic of the resource
improve cognition; memory; performance; programs; Psychiatry; Rehabilitation; scale; schizophrenia; severe mental-illness; support
Creator
An entity primarily responsible for making the resource
Nuechterlein K H; Green M F; Kern R S; Baade L E; Barch D M; Cohen J D; Essock S; Fenton W S; Frese F J; Gold J M; Goldberg T; Heaton R K; Keefe R S E; Kraemer H; Mesholam-Gately R; Seidman L J; Stover E; Weinberger D R; Young A S; Zalcman S; Marder S R
Description
An account of the resource
Objective: The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing treatments. A primary mandate of the National institute of Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative was to develop a consensus cognitive battery for clinical trials of cognition-enhancing treatments for schizophrenia through a broadly based scientific evaluation of measures. Method: The MATRICS Neurocognition Committee evaluated more than 90 tests in seven cognitive domains to identify the 36 most promising measures. A separate expert panel evaluated the degree to which each test met specific selection criteria. Twenty tests were selected as a beta battery. The beta battery was administered to 176 individuals with schizophrenia and readministered to 167 of them 4 weeks later so that the 20 tests could be compared directly. Results: The expert panel ratings are presented for the initially selected 36 tests. For the beta battery tests, data on test-retest reliability, practice effects, relationships to functional status, practicality, and tolerability are presented. Based on these data, 10 tests were selected to represent seven cognitive domains in the MATRICS Consensus Cognitive Battery. Conclusions: The structured consensus method was a feasible and fair mechanism for choosing candidate tests, and direct comparison of beta battery tests in a common sample allowed selection of a final consensus battery. The MATRICS Consensus Cognitive Battery is expected to be the standard tool for assessing cognitive change in clinical trials of cognition-enhancing drugs for schizophrenia. it may also aid evaluation of cognitive remediation strategies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1176/appi.ajp.2007.07010042" target="_blank" rel="noreferrer noopener">10.1176/appi.ajp.2007.07010042</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2008
American Journal of Psychiatry
Baade L E
Barch D M
Cohen J D
Essock S
Fenton W S
Frese F J
Gold J M
Goldberg T
Green M F
Heaton R K
improve cognition
Journal Article
Keefe R S E
Kern R S
Kraemer H
Marder S R
Memory
Mesholam-Gately R
Nuechterlein K H
Performance
programs
Psychiatry
Rehabilitation
scale
Schizophrenia
Seidman L J
severe mental-illness
Stover E
Support
Weinberger D R
Young A S
Zalcman S