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Text
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<a href="http://doi.org/10.1038/s41581-020-0267-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/s41581-020-0267-8</a>
ISSN
1759-507X 1759-5061
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1038/s41581-020-0267-8" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1038/s41581-020-0267-8</a>
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Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
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Title
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Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.
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Nature reviews. Nephrology
Date
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2020
2020-04-08
Creator
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Raina Rupesh; Bedoyan Jirair K; Lichter-Konecki Uta; Jouvet Philippe; Picca Stefano; Mew Nicholas Ah; Machado Marcel C; Chakraborty Ronith; Vemuganti Meghana; Grewal Manpreet K; Bunchman Timothy; Sethi Sidharth Kumar; Krishnappa Vinod; McCulloch Mignon; Alhasan Khalid; Bagga Arvind; Basu Rajit K; Schaefer Franz; Filler Guido; Warady Bradley A
Description
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Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in neonates and children. Moreover, consensus guidelines are lacking for the use of non-kidney replacement therapy (NKRT) and kidney replacement therapies (KRTs, including peritoneal dialysis, continuous KRT, haemodialysis and hybrid therapy) to manage hyperammonaemia in neonates and children. Prompt treatment with KRT and/or NKRT, the choice of which depends on the ammonia concentrations and presenting symptoms of the patient, is crucial. This expert Consensus Statement presents recommendations for the management of hyperammonaemia requiring KRT in paediatric populations. Additional studies are required to strengthen these recommendations.
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<a href="http://doi.org/10.1038/s41581-020-0267-8" target="_blank" rel="noreferrer noopener">10.1038/s41581-020-0267-8</a>
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journalArticle
2020
Alhasan Khalid
Bagga Arvind
Basu Rajit K
Bedoyan Jirair K
Bunchman Timothy
Chakraborty Ronith
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Filler Guido
Grewal Manpreet K
journalArticle
Jouvet Philippe
June 2020 Update II
Krishnappa Vinod
Lichter-Konecki Uta
Machado Marcel C
McCulloch Mignon
Mew Nicholas Ah
Nature reviews. Nephrology
NEOMED College of Medicine
Picca Stefano
Raina Rupesh
Schaefer Franz
Sethi Sidharth Kumar
Vemuganti Meghana
Warady Bradley A