1
40
3
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Text
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<a href="http://doi.org/10.3389/fnbeh.2016.00038" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnbeh.2016.00038</a>
Pages
38–38
Volume
10
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Contextual Modulation of Vocal Behavior in Mouse: Newly Identified 12 kHz "Mid-Frequency" Vocalization Emitted during Restraint.
Publisher
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Frontiers in behavioral neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
1905-07
Subject
The topic of the resource
mouse; context; isolation; restraint; stress; vocalization
Creator
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Grimsley Jasmine M S; Sheth Saloni; Vallabh Neil; Grimsley Calum A; Bhattal Jyoti; Latsko Maeson; Jasnow Aaron; Wenstrup Jeffrey J
Description
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While several studies have investigated mouse ultrasonic vocalizations (USVs) emitted by isolated pups or by males in mating contexts, studies of behavioral contexts other than mating and vocalization categories other than USVs have been limited. By improving our understanding of the vocalizations emitted by mice across behavioral contexts, we will better understand the natural vocal behavior of mice and better interpret vocalizations from mouse models of disease. Hypothesizing that mouse vocal behavior would differ depending on behavioral context, we recorded vocalizations from male CBA/CaJ mice across three behavioral contexts including mating, isolation, and restraint. We found that brief restraint elevated blood corticosterone levels of mice, indicating increased stress relative to isolation. Further, after 3 days of brief restraint, mice displayed behavioral changes indicative of stress. These persisted for at least 2 days after restraint. Contextual differences in mouse vocal behavior were striking and robust across animals. Thus, while USVs were the most common vocalization type across contexts, the spectrotemporal features of USVs were context-dependent. Compared to the mating context, vocalizations during isolation and restraint displayed a broader frequency range, with a greater emphasis on frequencies below 50 kHz. These contexts also included more non-USV vocal categories and different vocal patterns. We identified a new Mid-Frequency Vocalization, a tonal vocalization with fundamental frequencies below 18 kHz, which was almost exclusively emitted by mice undergoing restraint stress. These differences combine to form vocal behavior that is grossly different among behavioral contexts and may reflect the level of anxiety in these contexts.
Identifier
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<a href="http://doi.org/10.3389/fnbeh.2016.00038" target="_blank" rel="noreferrer noopener">10.3389/fnbeh.2016.00038</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Bhattal Jyoti
College of Anatomy & Neurobiology
context
Department of Anatomy & Neurobiology
Frontiers in behavioral neuroscience
Grimsley Calum A
Grimsley Jasmine M S
isolation
Jasnow Aaron
Latsko Maeson
mouse
NEOMED College of Medicine
Restraint
Sheth Saloni
Stress
Vallabh Neil
Vocalization
Wenstrup Jeffrey J
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2013.11.051" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2013.11.051</a>
Pages
152–157
Volume
559
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.
Publisher
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Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-01
Subject
The topic of the resource
*Disease Models; AHL; Animal; Animals; Auditory brainstem responses; Auditory Pathways/*growth & development/*pathology; Auditory system; DBA/2; Hearing Loss/*pathology; Inbred CBA; Inbred DBA; Mice; MNTB; Newborn; Olivary Nucleus/*growth & development/*pathology; Organ Culture Techniques
Creator
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Grimsley Calum A; Sivaramakrishnan Shobhana
Description
An account of the resource
Age-related hearing loss (AHL) is a multifactorial disorder characterized by a decline in peripheral and central auditory function. Here, we examined synaptic transmission in DBA/2 mice, which carry the AHL8 gene, at the identifiable glutamatergic synapse in the medial nucleus of the trapezoid body (MNTB), a nucleus in the superior olivary complex critical for acoustic timing. Mice exhibited raised auditory brainstem thresholds by P14, soon after hearing onset. Excitatory postsynaptic currents were prolonged; however, postsynaptic excitability was normal. By P18, high-frequency hearing loss was evident. Coincident with the onset of hearing loss, MNTB principal neurons displayed changes in intrinsic firing properties. These results suggest that changes in transmission in the superior olivary complex are associated with early onset hearing loss.
Identifier
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<a href="http://doi.org/10.1016/j.neulet.2013.11.051" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2013.11.051</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Disease Models
2014
AHL
Animal
Animals
Auditory brainstem responses
Auditory Pathways/*growth & development/*pathology
Auditory system
DBA/2
Grimsley Calum A
Hearing Loss/*pathology
Inbred CBA
Inbred DBA
Mice
MNTB
Neuroscience letters
Newborn
Olivary Nucleus/*growth & development/*pathology
Organ Culture Techniques
Sivaramakrishnan Shobhana
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2015.07.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2015.07.001</a>
Pages
206–217
Volume
253
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
An improved approach to separating startle data from noise.
Publisher
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Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-09
Subject
The topic of the resource
*Electronic Data Processing; *Noise; Acoustic startle reflex; Acoustic Stimulation/methods; Analysis of Variance; Animal locomotion; Animals; Auditory/*physiology; Automated classification; Evoked Potentials; Inbred CBA; Male; Mice; Reflex; Startle waveform analysis; Startle/*physiology; Time Factors; Video Recording
Creator
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Grimsley Calum A; Longenecker Ryan J; Rosen Merri J; Young Jesse W; Grimsley Jasmine M S; Galazyuk Alexander V
Description
An account of the resource
BACKGROUND: The acoustic startle reflex (ASR) is a rapid, involuntary movement to sound, found in many species. The ASR can be modulated by external stimuli and internal state, making it a useful tool in many disciplines. ASR data collection and interpretation varies greatly across laboratories making comparisons a challenge. NEW METHOD: Here we investigate the animal movement associated with a startle in mouse (CBA/CaJ). Movements were simultaneously captured with high-speed video and a piezoelectric startle plate. We also use simple mathematical extrapolations to convert startle data (force) into center of mass displacement ("height"), which incorporates the animal's mass. RESULTS: Startle plate force data revealed a stereotype waveform associated with a startle that contained three distinct peaks. This waveform allowed researchers to separate trials into 'startles' and 'no-startles' (termed 'manual classification). Fleiss' kappa and Krippendorff"s alpha (0.865 for both) indicate very good levels of agreement between researchers. Further work uses this waveform to develop an automated startle classifier. The automated classifier compares favorably with manual classification. A two-way ANOVA reveals no significant difference in the magnitude of the 3 peaks as classified by the manual and automated methods (P1: p=0.526, N1: p=0.488, P2: p=0.529). COMPARISON WITH EXISTING METHOD(S): The ability of the automated classifier was compared with three other commonly used classification methods; the automated classifier far outperformed these methods. CONCLUSIONS: The improvements made allow researchers to automatically separate startle data from noise, and normalize for an individual animal's mass. These steps ease inter-animal and inter-laboratory comparisons of startle data.
Identifier
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<a href="http://doi.org/10.1016/j.jneumeth.2015.07.001" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2015.07.001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Electronic Data Processing
*Noise
2015
Acoustic startle reflex
Acoustic Stimulation/methods
Analysis of Variance
Animal locomotion
Animals
Auditory/*physiology
Automated classification
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk Alexander V
Grimsley Calum A
Grimsley Jasmine M S
Inbred CBA
Journal of neuroscience methods
Longenecker Ryan J
Male
Mice
NEOMED College of Medicine
Reflex
Rosen Merri J
Startle waveform analysis
Startle/*physiology
Time Factors
Video Recording
Young Jesse W