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Text
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URL Address
<a href="http://doi.org/10.1016/S0003-9861(02)00066-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/S0003-9861(02)00066-8</a>
Pages
84–93
Issue
1
Volume
402
Dublin Core
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Title
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Phosphatidylinositide 3-kinase regulates angiotensin II-induced cytosolic phospholipase A2 activity and growth in vascular smooth muscle cells.
Publisher
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Archives of biochemistry and biophysics
Date
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2002
2002-06
Subject
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Angiotensin II/*metabolism; Animals; Arachidonic Acid/metabolism; Arachidonic Acids/pharmacology; Blotting; Cells; Chromones/pharmacology; Cultured; Enzyme Inhibitors/pharmacology; Flavonoids/pharmacology; Group IV Phospholipases A2; Male; Mitogen-Activated Protein Kinases/metabolism; Morpholines/pharmacology; Muscle; Phosphatidylinositol 3-Kinases/*physiology; Phospholipases A/*metabolism; Phospholipases A2; Phosphorylation; Rats; Smooth; Sprague-Dawley; Vascular/drug effects/*growth & development; Western
Creator
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Silfani Tonous N; Freeman Ernest J
Description
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Angiotensin (Ang) II via the AT(1) receptor acts as a mitogen in vascular smooth muscle cells (VSMC) through stimulation of multiple signaling mechanisms, including tyrosine kinases and mitogen-activated protein kinase (MAPK). In addition, cytosolic phospholipase A(2)(cPLA(2))-dependent release of arachidonic acid (AA) is linked to VSMC growth and we have reported that Ang II stimulates cPLA(2) activity via the AT(1) receptor. The coupling of Ang II to the activation of cPLA(2) appears to involve mechanisms both upstream and downstream of MAPK such that AA stimulates MAPK activity which phosphorylates cPLA(2) to further enhance AA release. However, the upstream mechanisms responsible for activation of cPLA(2) are not well-defined. One possibility includes phosphatidylinositide
Identifier
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<a href="http://doi.org/10.1016/S0003-9861(02)00066-8" target="_blank" rel="noreferrer noopener">10.1016/S0003-9861(02)00066-8</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Angiotensin II/*metabolism
Animals
Arachidonic Acid/metabolism
Arachidonic Acids/pharmacology
Archives of biochemistry and biophysics
Blotting
Cells
Chromones/pharmacology
Cultured
Enzyme Inhibitors/pharmacology
Flavonoids/pharmacology
Freeman Ernest J
Group IV Phospholipases A2
Male
Mitogen-Activated Protein Kinases/metabolism
Morpholines/pharmacology
Muscle
Phosphatidylinositol 3-Kinases/*physiology
Phospholipases A/*metabolism
Phospholipases A2
Phosphorylation
Rats
Silfani Tonous N
Smooth
Sprague-Dawley
Vascular/drug effects/*growth & development
Western