1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
931A-931A
Issue
4
Volume
52
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Transgenic Expression Of Cyp7a1 In Mouse Livers Promotes Biliary Cholesterol Secretion Via Fxr-dependent Induction Of Hepatic Abcg5 And Abcg8 Expression
Publisher
An entity responsible for making the resource available
Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Li T G; Kong B; Matozel M; Boehme S; Hsu P; Nilsson L M; Guo G L; Ellis E C S; Chiang J
Identifier
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n/a
Format
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Journal Article or Conference Abstract Publication
2010
Boehme S
Chiang J
Ellis E C S
Gastroenterology & Hepatology
Guo G L
Hepatology
Hsu P
Journal Article or Conference Abstract Publication
Kong B
Li T G
Matozel M
Nilsson L M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/hep.25740" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hep.25740</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1034-1043
Issue
3
Volume
56
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanism Of Tissue-specific Farnesoid X Receptor In Suppressing The Expression Of Genes In Bile-acid Synthesis In Mice
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-09
Subject
The topic of the resource
7-alpha-hydroxylase; activation; biosynthesis; cholesterol; feedback-regulation; fxr; Gastroenterology & Hepatology; homeostasis; molecular-basis; orphan nuclear receptor; signal; small heterodimer partner
Creator
An entity primarily responsible for making the resource
Kong B; Wang L; Chiang J Y L; Zhang Y C; Klaassen C D; Guo G L
Description
An account of the resource
Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism in suppressing bile-acid synthesis by reducing the expression levels of genes encoding key bile-acid synthetic enzymes (e.g., cytochrome P450 [CYP]7A1/Cyp7a1 and CYP8B1/Cyp8b1). FXR-mediated induction of hepatic small heterodimer partner (SHP/Shp, Nr0b2) and intestinal fibroblast growth factor 15 (Fgf15; FGF19 in humans) has been shown to be responsible for this suppression. However, the exact contribution of Shp/Fgf15 to this suppression, and the associated cell-signaling pathway, is unclear. By using novel genetically modified mice, the current study showed that the intestinal Fxr/Fgf15 pathway was critical for suppressing both Cyp7a1 and Cyp8b1 gene expression, but the liver Fxr/Shp pathway was important for suppressing Cyp8b1 gene expression and had a minor role in suppressing Cyp7a1 gene expression. Furthermore, in vivo administration of Fgf15 protein to mice led to a strong activation of extracellular signal-related kinase (ERK) and, to a smaller degree, Jun N-terminal kinase (JNK) in the liver. In addition, deficiency of either the ERK or JNK pathway in mouse livers reduced the basal, but not the Fgf15-mediated, suppression of Cyp7a1 and Cyp8b1 gene expression. However, deficiency of both ERK and JNK pathways prevented Fgf15-mediated suppression of Cyp7a1 and Cyp8b1 gene expression. Conclusion: The current study clearly elucidates the underlying molecular mechanism of hepatic versus intestinal Fxr in regulating the expression of genes critical for bile-acid synthesis and hydrophobicity in the liver. (HEPATOLOGY 2012;56:10341043)
Identifier
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<a href="http://doi.org/10.1002/hep.25740" target="_blank" rel="noreferrer noopener">10.1002/hep.25740</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
7-alpha-hydroxylase
activation
biosynthesis
Chiang J Y L
Cholesterol
feedback-regulation
FXR
Gastroenterology & Hepatology
Guo G L
Hepatology
Homeostasis
Journal Article or Conference Abstract Publication
Klaassen C D
Kong B
molecular-basis
orphan nuclear receptor
signal
small heterodimer partner
Wang L
Zhang Y C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
397A-397A
Volume
54
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differential Roles Of Intestinal Fgf15 And Hepatic Shp In Feed-back Suppression Of Cyp7a1 And Cyp8b1 Gene Transcription In Mice
Publisher
An entity responsible for making the resource available
Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Kong B; Wang L; Chiang J; Guo G L
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
Chiang J
Gastroenterology & Hepatology
Guo G L
Hepatology
Journal Article or Conference Abstract Publication
Kong B
Wang L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1124/dmd.112.048694" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/dmd.112.048694</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-11
Issue
1
Volume
41
Search for Full-text
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Dublin Core
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Title
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Role of Nuclear Receptors in Lipid Dysfunction and Obesity-Related Diseases
Publisher
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Drug Metabolism and Disposition
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
bile-acid-homeostasis; carbohydrate-metabolism; constitutive androstane receptor; estrogen sulfotransferase; farnesoid X receptor; fatty liver-disease; glucose-homeostasis; heterodimer partner; insulin sensitivity; Pharmacology & Pharmacy; small; type-2 diabetes-mellitus
Creator
An entity primarily responsible for making the resource
Swanson H I; Wada T; Xie W; Renga B; Zampella A; Distrutti E; Fiorucci S; Kong B; Thomas A M; Guo G L; Narayanan R; Yepuru M; Dalton J T; Chiang J Y L
Description
An account of the resource
This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the Experimental Biology 12 meeting in San Diego, CA. The presentations discussed the roles of a number of nuclear receptors in regulating glucose and lipid homeostasis, the pathophysiology of obesity-related disease states, and the promise associated with targeting their activities to treat these diseases. While many of these receptors (in particular, constitutive androstane receptor and pregnane X receptor) and their target enzymes have been thought of as regulators of drug and xenobiotic metabolism, this symposium highlighted the advances made in our understanding of the endogenous functions of these receptors. Similarly, as we gain a better understanding of the mechanisms underlying bile acid signaling pathways in the regulation of body weight and glucose homeostasis, we see the importance of using complementary approaches to elucidate this fascinating network of pathways. The observation that some receptors, like the farnesoid X receptor, can function in a tissue-specific manner via well defined mechanisms has important clinical implications, particularly in the treatment of liver diseases. Finally, the novel findings that agents that selectively activate estrogen receptor beta can effectively inhibit weight gain in a high-fat diet model of obesity identifies a new role for this member of the steroid superfamily. Taken together, the significant findings reported during this symposium illustrate the promise associated with targeting a number of nuclear receptors for the development of new therapies to treat obesity and other metabolic disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1124/dmd.112.048694" target="_blank" rel="noreferrer noopener">10.1124/dmd.112.048694</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
bile-acid-homeostasis
carbohydrate-metabolism
Chiang J Y L
constitutive androstane receptor
Dalton J T
Distrutti E
Drug Metabolism and Disposition
estrogen sulfotransferase
Farnesoid X receptor
fatty liver-disease
Fiorucci S
glucose-homeostasis
Guo G L
heterodimer partner
insulin sensitivity
Journal Article
Kong B
Narayanan R
Pharmacology & Pharmacy
Renga B
Small
Swanson H I
Thomas A M
type-2 diabetes-mellitus
Wada T
Xie W
Yepuru M
Zampella A