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40
7
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Text
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<a href="http://doi.org/10.1016/j.carrev.2020.12.024" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.carrev.2020.12.024</a>
Pages
88-89
Volume
27
ISSN
1553-8389
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July 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
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Title
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Adverse Events Related to Excimer Laser Coronary Atherectomy: Analysis of the FDA MAUDE Database
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Cardiovascular Revascularization Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-06
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Bansal A; Gupta S; Jain V; Tsutsui R; Reed GW; Puri R; Hedrick DP; Kanaa'N A; Khatri JJ; Kapadia SR; Kalra A
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<a href="http://doi.org/10.1016/j.carrev.2020.12.024" target="_blank" rel="noreferrer noopener">10.1016/j.carrev.2020.12.024</a>
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journalArticle
2021
Bansal A
Cardiovascular Revascularization Medicine
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Gupta S
Hedrick DP
Jain V
journalArticle
July 2021 List
Kalra A
Kanaa'N A
Kapadia SR
Khatri JJ
NEOMED College of Medicine
Puri R
Reed GW
Tsutsui R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/10.1161/ATVBAHA.120.314962" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/ATVBAHA.120.314962</a>
Pages
ATVBAHA120314962
ISSN
1524-4636 1079-5642
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January 2021 List
NEOMED College
NEOMED College of Medicine
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Department of Integrative Medical Sciences
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Title
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TSP-1 (thrombospondin-1) deficiency protects APOE(-/-) mice against leptin-induced atherosclerosis.
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Arteriosclerosis, Thrombosis, and Vascular Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-17
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atherosclerosis; leptin; obesity; smooth muscle; thrombospondins
Creator
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Ganguly R; Khanal S; Mathias A; Gupta S; Lallo J; Sahu S; Ohanyan VA; Patel A; Storm K; Datta S; Raman P
Description
An account of the resource
OBJECTIVE: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on TSP-1 (thrombospondin-1) expression, a proatherogenic matricellular protein implicated in atherogenesis. However, a causal role of TSP-1 in leptin-driven atherosclerosis remains unknown. Approach and Results: Seventeen-weeks-old ApoE(-/-) and TSP-1(-/-)/ApoE(-/-) double knockout mice, on normocholesterolemic diet, were treated with or without murine recombinant leptin (5 µg/g bwt, IP) once daily for 3 weeks. Using aortic root morphometry and en face lesion assay, we found that TSP-1 deletion abrogated leptin-stimulated lipid-filled lesion burden, plaque area, and collagen accumulation in aortic roots of ApoE(-/-) mice, shown via Oil red O, hematoxylin and eosin, and Masson trichrome staining, respectively. Immunofluorescence microscopy of aortic roots showed that TSP-1 deficiency blocked leptin-induced inflammatory and smooth muscle cell abundance as well as cellular proliferation in ApoE(-/-) mice. Moreover, these effects were concomitant to changes in VLDL (very low-density lipoprotein)-triglyceride and HDL (high-density lipoprotein)-cholesterol levels. Immunoblotting further revealed reduced vimentin and pCREB accompanied with augmented smooth muscle-myosin heavy chain expression in aortic vessels of leptin-treated double knockout versus leptin-treated ApoE(-/-); also confirmed in aortic smooth muscle cells from the mice genotypes, incubated ± leptin in vitro. Finally, TSP-1 deletion impeded plaque burden in leptin-treated ApoE(-/-) on western diet, independent of plasma lipid alterations. CONCLUSIONS: The present study provides evidence for a protective effect of TSP-1 deletion on leptin-stimulated atherogenesis. Our findings suggest a regulatory role of TSP-1 on leptin-induced vascular smooth muscle cell phenotypic transition and inflammatory lesion invasion. Collectively, these results underscore TSP-1 as a potential target of leptin-induced vasculopathy.
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<a href="http://doi.org/10.1161/ATVBAHA.120.314962" target="_blank" rel="noreferrer noopener">10.1161/ATVBAHA.120.314962</a>
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journalArticle
2020
and vascular biology
Arteriosclerosis
Arteriosclerosis, thrombosis, and vascular biology
Atherosclerosis
Datta S
Department of Integrative Medical Sciences
Ganguly R
Gupta S
January 2021 List
journalArticle
Khanal S
Lallo J
leptin
Mathias A
NEOMED College of Medicine
Obesity
Ohanyan VA
Patel A
Raman P
Sahu S
smooth muscle
Storm K
Thrombosis
thrombospondins
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.urology.2020.11.017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.urology.2020.11.017</a>
ISSN
1527-9995 0090-4295
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December 2020 List
NEOMED College
NEOMED College of Medicine Student
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NEOMED Student Publications
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Title
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Author Reply to Letter-to-the-Editor on: Validating the Martini Staging System for Rectourethral Fistula.
Publisher
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Urology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11-19
Creator
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Mishra K; Mahran A; Abboud B; Elshafei A; Bukavina L; Zhao LC; Gupta S
Identifier
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<a href="http://doi.org/10.1016/j.urology.2020.11.017" target="_blank" rel="noreferrer noopener">10.1016/j.urology.2020.11.017</a>
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journalArticle
2020
Abboud B
Bukavina L
December 2020 List
Elshafei A
Gupta S
journalArticle
Mahran A
Mishra K
NEOMED College of Medicine Student
NEOMED Student Publications
Urology
Zhao LC
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1096/fasebj.2020.34.s1.03648" target="_blank" rel="noreferrer noopener">http://doi.org/10.1096/fasebj.2020.34.s1.03648</a>
Issue
1
Volume
34
ISSN
0892-6638
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September 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Department of Integrative Medical Sciences
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Title
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Alzheimers disease-related pathology and impaired cognitive function associate with reduced O-GLCNAC transferase in aged metabolic syndrome KKAY(+/-) mice
Publisher
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Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Creator
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Jinka S;Lallo Jason;Gupta S;Mathias A;Khanal S;Al-Rhayyel Y;Herman D;Fleming S;Raman P
Description
An account of the resource
Metabolic syndrome (MetS) refers to a cluster of anomalies including type 2 diabetes, obesity, insulin resistance and dyslipidemia. Patients with MetS are 1.5 times more likely to develop late‐onset Alzheimer’s Disease (AD), with impaired glucose metabolism, defective insulin signaling, increased oxidative stress and inflammation being shared between the comorbid diseases. Notably, risk of AD is profoundly enhanced in the aging MetS population. Recent studies in AD patients and AD mouse models suggest a putative link between hyperphosphorylated tau neurofibrillary tangles, a commonly accepted AD pathology, and cerebral glucose hypometabolism. Impaired glucose metabolism is characterized by reduced glucose flux through the hexosamine metabolic pathway triggering attenuated signaling via O‐linked N‐acetylglucosamine (O‐GlcNAc) transferase (OGT), a major regulator of intracellular protein O‐GlcNAcylation. However, the role of OGT in the etiology of MetS‐induced AD remains incompletely understood. The goal of the present study was to examine the link between cognitive function, AD pathology and OGT signaling in a mouse model of MetS (KKAy+/−) that develops increased body weight, hyperglycemia, elevated total cholesterol and total triglyceride levels. Briefly, male and female obese agouti KKAy+/−, lean non‐agouti KKAy−/− and normal C57BL/6 control mice weaned at 4 wks of age on regular chow diet were subjected to periodic body weight and random blood glucose monitoring followed by a battery of behavioral tests at 12+ months of age. Plasma and brain (frontal cortex and hippocampus) tissues were then harvested from each genotype for biochemical and molecular studies. In an object recognition test of attention and memory, obese KKAy+/− mice showed a more severe impairment in discrimination between a novel and familiar object compared to lean KKAy−/− and normal C57BL/6 mice. Additionally, in a test of spontaneous activity obese KKAy+/− mice made significantly fewer rears vs lean KKAy−/− mice and wild‐type C57BL/6 controls; these results suggest diminished cognitive function in the obese KKAy+/− mice. Furthermore, immunoblotting of brain tissue lysates derived from the agouti KKAy+/− mice revealed increased ptau expression coupled with reduced pERK (signaling mediator of neuronal function) and pGSK (inactive form of tau kinase GSK3β) expression compared to non‐agouti KKAy−/−. Importantly, augmented tau phosphorylation was concomitant to attenuated OGT expression in brain lysates of obese KKAy+/− mice. Together, these data demonstrate a direct association between cognitive dysfunction, AD‐related pathology and reduced OGT expression in aged MetS KKAy+/− mice. Overall, our study implicates a role of OGT in MetS‐induced cognitive decline and AD pathogenesis.
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<a href="http://doi.org/10.1096/fasebj.2020.34.s1.03648" target="_blank" rel="noreferrer noopener">10.1096/fasebj.2020.34.s1.03648</a>
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journalArticle
2020
Al-Rhayyel Y
Department of Integrative Medical Sciences
Faseb Journal
Fleming S
Gupta S
Herman D
Jinka S
journalArticle
Khanal S
Lallo Jason
Mathias A
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
Raman P
September 2020 List
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.urology.2020.08.047" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.urology.2020.08.047</a>
ISSN
1527-9995
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September 2020 List
NEOMED College
NEOMED College of Medicine Student
NEOMED Department
NEOMED Student Publications
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Title
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Validating the martini staging system for rectourethral fistula: A meta-analysis of postoperative outcomes.
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Urology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-09-08
Creator
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Mishra K;Mahran A;Abboud B;Bukavina L;Elshafei A;Ray A;Fernstrum A;Abboud R;Elgammal M;Zhao LC;Gupta S
Description
An account of the resource
Objective: To validate the Martini staging system for postoperative rectourethral fistula (RUF) utilizing data from previous studies to determine whether it can accurately predict postoperative success rate.; Methods: A systematic search of peer-reviewed studies was conducted through January, 2020. The primary inclusion criteria for the studies were studies that evaluated outcomes based on the etiology of the fistula (ie, radiotherapy/ablation [RA] vs nonradiotherapy/ablation [NRA]). Martini RUF classification was utilized for the subgroup analysis.; Results: Out of 1948 papers, 7 studies with a total of 490 patients (251 in RA vs 239 NRA) were included in this study. Receiving RA increased the risk of permanent bowel diversion by 11.1 folds, eventual fistula recurrence by 9.1 folds, and post-op urinary incontinence (UI) by 2.6 folds. Similarly, compared to a Grade 0 fistula, a Grade I fistula increased the risk of permanent bowel diversion by 9.1 folds, fistula recurrence by 20 folds, and post-op UI by 2.7 folds. There were some valuable variables that were not captured by the Martini classification.; Conclusion: Overall, the Martini classification system is efficacious in stratifying post-op complications from RUF repair based on the grade and etiology; however, it is limited in application. There is an opportunity for the development of more comprehensive staging systems in this domain. (Copyright © 2020 Elsevier Inc. All rights reserved.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.urology.2020.08.047" target="_blank" rel="noreferrer noopener">10.1016/j.urology.2020.08.047</a>
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journalArticle
2020
Abboud B
Abboud R
Bukavina L
Elgammal M
Elshafei A
Fernstrum A
Gupta S
journalArticle
Mahran A
Mishra K
NEOMED College of Medicine Student
NEOMED Student Publications
Ray A
September 2020 List
Urology
Zhao LC
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S231-S232
Volume
65
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Title
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Profiling Srf And Modulation Of Srf Target Genes In A Mouse Model Of Cardiac Aging
Publisher
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Journal of the American Geriatrics Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
Geriatrics & Gerontology
Creator
An entity primarily responsible for making the resource
Gupta S; Gopalkrishna S; Schmidt A; Ramasamy R
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n/a
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Journal Article or Conference Abstract Publication
2017
Geriatrics & Gerontology
Gopalkrishna S
Gupta S
Journal Article or Conference Abstract Publication
Journal of the American Geriatrics Society
Ramasamy R
Schmidt A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ijrobp.2008.04.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ijrobp.2008.04.001</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
15-23
Issue
1
Volume
73
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A name given to the resource
RADIOTHERAPY AND SURVIVAL IN PROSTATE CANCER PATIENTS: A POPULATION-BASED STUDY
Publisher
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International Journal of Radiation Oncology Biology Physics
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-01
Subject
The topic of the resource
active surveillance; brachytherapy; carcinoma; external-beam radiotherapy; failure; management; Nuclear Medicine & Medical Imaging; Oncology; outcomes; Population-based study; Prostate cancer; radiation-therapy; radical prostatectomy; Radiology; risk; survival; Treatment modalities
Creator
An entity primarily responsible for making the resource
Zhou E H; Ellis R T; Cherullo E; Colussi V; Xu F; Chen W D; Gupta S; Whalen C C; Bodner D; Resnick M I; Rimm A A; Koroukian S M
Description
An account of the resource
Purpose: To investigate the association of overall and disease-specific survival with the five standard treatment modalities for prostate cancer (CaP): radical prostatectomy (RP), brachytherapy (BT), external beam radiotherapy, androgen deprivation therapy, and no treatment (NT) within 6 months after CaP diagnosis. Methods and Materials: The study population included 10,179 men aged 65 years and older with incident CaP diagnosed between 1999 and 2001. Using the linked Ohio Cancer Incidence Surveillance System, Medicare, and death certificate files, overall and disease-specific survival through 2005 among the five clinically accepted therapies were analyzed. Results: Disease-specific survival rates were 92.3% and 23.9% for patients with localized vs. distant disease at 7 years, respectively. Controlling for age, race, comorbidities, stage, and Gleason score, results from the Cox multiple regression models indicated that the risk of CaP-specific death was significantly reduced in patients receiving RP or BT, compared with NT. For localized disease, compared with NT, in the monotherapy cohort, RP and BT were associated with reduced hazard ratios (HR) of 0.25 and 0.45 (95% confidence intervals 0.13-0.48 and 0.23-0.87, respectively), whereas in the combination therapy cohort, HR were 0.40 (0.17-0.94) and 0.46 (0.270.80), respectively. Conclusions: The present population-based study indicates that RP and BT are associated with improved survival outcomes. Further studies are warranted to improve clinical determinates in the selection of appropriate management of CaP and to improve predictive modeling for which patient subsets may benefit most from definitive therapy vs. conservative management and/or observation. (C) 2009 Elsevier Inc.
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<a href="http://doi.org/10.1016/j.ijrobp.2008.04.001" target="_blank" rel="noreferrer noopener">10.1016/j.ijrobp.2008.04.001</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2009
active surveillance
Bodner D
brachytherapy
Carcinoma
Chen W D
Cherullo E
Colussi V
Ellis R T
external-beam radiotherapy
failure
Gupta S
International Journal of Radiation Oncology Biology Physics
Journal Article
Koroukian S M
Management
Nuclear Medicine & Medical Imaging
oncology
outcomes
Population-based study
Prostate cancer
radiation-therapy
radical prostatectomy
Radiology
Resnick M I
Rimm A A
Risk
Survival
Treatment modalities
Whalen C C
Xu F
Zhou E H