1
40
2
-
Text
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
3279-3287
Issue
4
Volume
23
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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The in vitro antitumor activity of vitamins C and K-3 against ovarian carcinoma
Publisher
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Anticancer Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-07
Subject
The topic of the resource
alternative medicine use; aspects; autoschizis; cancer-chemotherapy; cell-lines; double-blind; k-3 combinations; mitomycin-c; Oncology; ovarian-cancer; phase-ii trial; pretreatment; tumor; ultrastructural; vitamin C; vitamin K-3
Creator
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Von Gruenigen V E; Jamison J M; Gilloteaux J; Lorimer H E; Summers M; Pollard R R; Gwin C A; Summers J L
Description
An account of the resource
Background: The objective was to evaluate the cytotoxic effect and mechanism of action of vitamins C (VC) and K-3 (VK3) on ovarian carcinoma. Materials and Methods: Cytotoxicity assays were performed on ovarian cancer cell lines with VC, VK3 or a VC/VK3 combination. FIC index was employed to evaluate synergism. Flow cytometry was accomplished at 90% cytotoxic doses. Light, transmission electron microscopy and DNA isolation were performed. Results: Antitumor activity was exhibited by both VC, VK3 and VC/VK3. VC/VK3 demonstrated synergistic activity. VC/VK3 may induce a G(1) block in the cell cycle. Combined vitamin treatment resulted in cells that maintain apparently intact nuclei while extruding pieces of organelle-free cytoplasm. Degradation of chromosomal DNA was observed. Conclusion: Cell death (autoschizis) displayed characteristics of both apoptosis and necrosis. The cytotoxic effects observed may enable vitamins C and K-3 to play an adjuvant role in the treatment of ovarian cancer.
Identifier
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n/a
Format
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Journal Article
2003
alternative medicine use
Anticancer research
aspects
autoschizis
cancer-chemotherapy
cell-lines
double-blind
Gilloteaux J
Gwin C A
Jamison J M
Journal Article
k-3 combinations
Lorimer H E
mitomycin-c
oncology
ovarian-cancer
phase-ii trial
Pollard R R
pretreatment
Summers J L
Summers M
Tumor
ultrastructural
vitamin C
vitamin K-3
von Gruenigen V E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/002215540104900111" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/002215540104900111</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
109-119
Issue
1
Volume
49
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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In vivo reactivation of DNases in implanted human prostate tumors after administration of a vitamin C/K-3 combination
Publisher
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Journal of Histochemistry & Cytochemistry
Date
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2001
2001-01
Subject
The topic of the resource
apoptosis; cancer; cancer-chemotherapy; carcinoma cells; Cell Biology; cell death; deoxyribonuclease-ii; DNASE; growth-invitro; identification; lines; necrobiology; pretreatment; programmed cell-death; Prostate cancer; synergistic antitumor-activity; vitamin C; vitamin K-3
Creator
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Taper H S; Jamison J M; Gilloteaux J; Gwin C A; Gordon T; Summers J L
Description
An account of the resource
Human prostate cancer cells (DU145) implanted into nude mice are deficient in DNase activity. After administration of a vitamin C/vitamin K-3 combination, both alkaline DNase (DNase I) and acid DNase (DNase II) activities were detected in cryosections with a histochemical lead nitrate technique. Alkaline DNase activity appeared 1 hr after vitamin administration, decreased slightly until 2 hr, and disappeared by 8 hr after treatment. Acid DNase activity appeared 2 hr after vitamin administration, reached its highest levels between 4 and 8 hr, and maintained its activity 24 hr after treatment. Methyl green staining indicated that DNase expression was accompanied by a decrease in DNA content of the tumor cells. Microscopic examination of 1-mum sections of the tumors indicated that DNase reactivation and the subsequent degradation of DNA induced multiple forms of tumor cell death, including apoptosis and necrosis. The primary form of vitamin-induced tumor cell death was autoschizis, which is characterized by membrane damage and the progressive loss of cytoplasm through a series of self-excisions. These self-excisions typically continue until the perikaryon consists of an apparently intact nucleus surrounded by a thin rim of cytoplasm that contains damaged organelles.
Identifier
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<a href="http://doi.org/10.1177/002215540104900111" target="_blank" rel="noreferrer noopener">10.1177/002215540104900111</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
Apoptosis
Cancer
cancer-chemotherapy
carcinoma cells
Cell Biology
Cell Death
deoxyribonuclease-ii
DNASE
Gilloteaux J
Gordon T
growth-invitro
Gwin C A
identification
Jamison J M
Journal Article
Journal of Histochemistry & Cytochemistry
lines
necrobiology
pretreatment
programmed cell-death
Prostate cancer
Summers J L
synergistic antitumor-activity
Taper H S
vitamin C
vitamin K-3