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Text
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<a href="http://doi.org/10.1089/ars.2020.8180" target="_blank" rel="noreferrer noopener">http://doi.org/10.1089/ars.2020.8180</a>
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1557-7716
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May 2021 List
NEOMED College
NEOMED College of Pharmacy
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Department of Pharmaceutical Sciences
NEOMED Student Publications
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Title
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Oxidative Stress and Hypoxia Modify Mitochondrial Homeostasis During Glaucoma.
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Antioxidants & Redox Signaling
Date
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2021
2021-04-29
Subject
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glaucoma; oxidative stress; hypoxia; glycolysis; HIF-1α; PGC-1α
Creator
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Jassim AH; Fan Y; Pappenhagen N; Nsiah NY; Inman DM
Description
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Aims: Cellular response to hypoxia can include transition from respiration to glycolysis via upregulation of glycolytic enzymes and transporters, as well as mitophagy induction to eliminate surplus mitochondria. Our purpose was to evaluate the impact of hypoxia-inducible factor-1α (HIF-1α) stabilization on mitochondrial homeostasis and oxidative stress in a chronic model of glaucoma. Results: Retina and optic nerve (ON) were evaluated from young and aged DBA/2J (D2) glaucoma model mice and the control strain, the DBA/2- Gpnmb + . Hypoxic retinal ganglion cells (RGCs) were observed in young and aged D2 retina, with a significant increase in HIF-1α protein in the aged D2 retina. Reactive oxygen species observed in young D2 retina and ON were followed by significant decreases in antioxidant capacity in aged D2 retina and ON. HIF-1α targets such as neuron-specific glucose transporter-3 and lactate dehydrogenase were decreased or unchanged, respectively, in aged D2 retina despite an increased hypoxia response in RGCs. Mitochondrial mass was decreased in aged D2 retina concomitant with decreased mitochondrially encoded electron transport chain transcripts despite a stable nuclear-encoded TFAM (mitochondrial transcription factor), suggesting a breakdown in the nuclear-mitochondrial communication. Decreased mitophagy-associated proteins p62 and Rheb were observed in aged D2 retina, although p62 was significantly increased in the aged D2 ON. Innovation and Conclusion: The increased reactive oxygen species concomitant with HIF-1α upregulation despite reduced glucose transporters, mis-match of nuclear- and mitochondrial-encoded transcripts, and signs of reduced mitophagy suggest that retinas from D2 mice with chronic intraocular pressure elevation transition to pseudohypoxia without consistent metabolic reprogramming before significant RGC loss.
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<a href="http://doi.org/10.1089/ars.2020.8180" target="_blank" rel="noreferrer noopener">10.1089/ars.2020.8180</a>
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journalArticle
2021
Antioxidants & redox signaling
Department of Pharmaceutical Sciences
Fan Y
Glaucoma
glycolysis
HIF-1α
hypoxia
Inman DM
Jassim AH
journalArticle
May 2021 List
NEOMED College of Pharmacy Student
NEOMED Student Publications
Nsiah NY
Oxidative Stress
Pappenhagen N
PGC-1α
-
Dublin Core
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Title
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Articles Published in 2021
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Shelley Harrell
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Shelley Harrell
Date
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2021
Description
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Items published in 2021
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1089/ars.2020.8180">http://doi.org/10.1089/ars.2020.8180</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pharmaceutical Sciences
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oxidative Stress and Hypoxia Modify Mitochondrial Homeostasis During Glaucoma.
Creator
An entity primarily responsible for making the resource
Jassim AH; Fan Y; Pappenhagen N; Nsiah NY; Inman DM
Publisher
An entity responsible for making the resource available
Antioxidants & Redox Signaling
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-04-29
Description
An account of the resource
Aims: Cellular response to hypoxia can include transition from respiration to glycolysis via upregulation of glycolytic enzymes and transporters, as well as mitophagy induction to eliminate surplus mitochondria. Our purpose was to evaluate the impact of hypoxia-inducible factor-1α (HIF-1α) stabilization on mitochondrial homeostasis and oxidative stress in a chronic model of glaucoma. Results: Retina and optic nerve (ON) were evaluated from young and aged DBA/2J (D2) glaucoma model mice and the control strain, the DBA/2-Gpnmb+. Hypoxic retinal ganglion cells (RGCs) were observed in young and aged D2 retina, with a significant increase in HIF-1α protein in the aged D2 retina. Reactive oxygen species observed in young D2 retina and ON were followed by significant decreases in antioxidant capacity in aged D2 retina and ON. HIF-1α targets such as neuron-specific glucose transporter-3 and lactate dehydrogenase were decreased or unchanged, respectively, in aged D2 retina despite an increased hypoxia response in RGCs. Mitochondrial mass was decreased in aged D2 retina concomitant with decreased mitochondrially encoded electron transport chain transcripts despite a stable nuclear-encoded TFAM (mitochondrial transcription factor), suggesting a breakdown in the nuclear-mitochondrial communication. Decreased mitophagy-associated proteins p62 and Rheb were observed in aged D2 retina, although p62 was significantly increased in the aged D2 ON. Innovation and Conclusion: The increased reactive oxygen species concomitant with HIF-1α upregulation despite reduced glucose transporters, mis-match of nuclear- and mitochondrial-encoded transcripts, and signs of reduced mitophagy suggest that retinas from D2 mice with chronic intraocular pressure elevation transition to pseudohypoxia without consistent metabolic reprogramming before significant RGC loss
Identifier
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1089/ars.2020.8180">http://doi.org/10.1089/ars.2020.8180</a></td>
</tr></tbody></table>
Format
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Journal Article
2021
Glaucoma
glycolysis
HIF-1α
hypoxia
Oxidative Stress
PGC-1α