1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11136-017-1745-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11136-017-1745-8</a>
Pages
1089–1098
Issue
4
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Minimal clinically important differences in the EORTC QLQ-C30 and brief pain inventory in patients undergoing re-irradiation for painful bone metastases.
Publisher
An entity responsible for making the resource available
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-04
Subject
The topic of the resource
*Bone metastases; *Brief pain inventory; *EORTC QLQ-C30; *Minimal Clinically Important Difference; *Minimal clinically important differences; *Radiation; 80 and over; 80 and Over; Adolescence; Adolescent; Adult; Aged; Bone Metastases – Radiotherapy; BONE metastasis; BONE metastasis – Treatment; Bone Neoplasms/*complications/radiotherapy/secondary; Brief Pain Inventory; BRIEF Pain Inventory; Cancer Patients; CANCER patients; CANCER radiotherapy; Clinical Assessment Tools; Female; Funding Source; Human; Humans; Instrument Scaling; LONGITUDINAL method; Male; Middle Age; Middle Aged; Pain Management; PAIN management; Pain/*diagnosis; Prospective Studies; Quality of Life/*psychology; Questionnaires; QUESTIONNAIRES; RANDOMIZED controlled trials; Re-Irradiation/*adverse effects; REOPERATION; Repeat Procedures; RESEARCH funding; SCALING (Social sciences); Secondary Analysis; SECONDARY analysis; Surveys and Questionnaires; Young Adult
Creator
An entity primarily responsible for making the resource
Raman Srinivas; Ding Keyue; Chow Edward; Meyer Ralph M; van der Linden Yvette M; Roos Daniel; Hartsell William F; Hoskin Peter; Wu Jackson S Y; Nabid Abdenour; Haas Rick; Wiggenraad Ruud; Babington Scott; Demas William F; Wilson Carolyn F; Wong Rebecca K S; Zhu Liting; Brundage Michael
Description
An account of the resource
PURPOSE: The EORTC QLQ-C30 and the Brief Pain Inventory (BPI) are validated tools for measuring quality of life (QOL) and the impact of pain in patients with advanced cancer. Interpretation of these instrument scores can be challenging and it is difficult to know what numerical changes translate to clinically significant impact in patients' lives. To address this issue, our study sought to establish the minimal clinically important differences (MCID) for these two instruments in a prospective cohort of patients with advanced cancer and painful bone metastases. METHODS: Both anchor-based and distribution-based methods were used to estimate the MCID scores from patients enrolled in a randomized phase III trial evaluating two different re-irradiation treatment schedules. For the anchor-based method, the global QOL item from the QLQ-C30 was chosen as the anchor. Spearman correlation coefficients were calculated for all items and only those items with moderate or better correlation (\textbarr\textbar \textgreater/= 0.30) with the anchor were used for subsequent analysis. A 10-point difference in the global QOL score was used to classify improvement and deterioration, and the MCID scores were calculated for each of these categories. These results were compared with scores obtained by the distribution-method, which estimates the MCID purely from the statistical characteristics of the sample population. RESULTS: A total of 375 patients were included in this study with documented pain responses and completed QOL questionnaires at 2 months. 9/14 items in the QLQ-C30 and 6/10 items in the BPI were found to have moderate or better correlation with the anchor. For deterioration, statistically significant MCID scores were found in all items of the QLQ-C30 and BPI. For improvement, statistically significant MCID scores were found in 7/9 items of the QLQ-C30 and 2/6 items of the BPI. The MCID scores for deterioration were uniformly higher than the MCIDs for improvement. Using the distribution-based method, there was good agreement between the 0.5 standard deviation (SD) values and anchor-based scores for deterioration. For improvement, there was less agreement and the anchor-based scores were lower than the 0.5 SD values obtained from the distribution-based method. CONCLUSION: We present MCID scores for the QLQ-C30 and BPI instruments obtained from a large cohort of patients with advanced cancer undergoing re-irradiation for painful bone metastases. The results from this study were compared to other similar studies which showed larger MCID scores for improvement compared to deterioration. We hypothesize that disease trajectory and patient expectations are important factors in understanding the contrasting results. The results of this study can guide clinicians and researchers in the interpretation of these instruments.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11136-017-1745-8" target="_blank" rel="noreferrer noopener">10.1007/s11136-017-1745-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Bone metastases
*Brief pain inventory
*EORTC QLQ-C30
*Minimal Clinically Important Difference
*Minimal clinically important differences
*Radiation
2018
80 and over
Adolescence
Adolescent
Adult
Aged
Babington Scott
Bone Metastases – Radiotherapy
BONE metastasis
BONE metastasis – Treatment
Bone Neoplasms/*complications/radiotherapy/secondary
Brief pain inventory
Brundage Michael
Cancer Patients
CANCER radiotherapy
Chow Edward
Clinical Assessment Tools
Demas William F
Ding Keyue
Female
Funding Source
Haas Rick
Hartsell William F
Hoskin Peter
Human
Humans
Instrument Scaling
LONGITUDINAL method
Male
Meyer Ralph M
Middle Age
Middle Aged
Nabid Abdenour
Pain Management
Pain/*diagnosis
Prospective Studies
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Quality of Life/*psychology
Questionnaires
Raman Srinivas
RANDOMIZED controlled trials
Re-Irradiation/*adverse effects
Reoperation
Repeat Procedures
RESEARCH funding
Roos Daniel
SCALING (Social sciences)
Secondary Analysis
Surveys and Questionnaires
van der Linden Yvette M
Wiggenraad Ruud
Wilson Carolyn F
Wong Rebecca K S
Wu Jackson S Y
Young Adult
Zhu Liting