1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00214.2003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00214.2003</a>
Pages
L756–766
Issue
4
Volume
286
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
IL-1beta stimulates alveolar fluid absorption in fetal guinea pig lungs via the hypothalamus-pituitary-adrenal gland axis.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
Adrenocorticotropic Hormone/blood; Animals; Epinephrine/blood; Epithelial Sodium Channels; Extravascular Lung Water/*metabolism; Female; Guinea Pigs; Hydrocortisone/blood; Hypothalamo-Hypophyseal System/*physiology; Interleukin-1/blood/*pharmacology; Norepinephrine/blood; Pituitary-Adrenal System/*physiology; Pregnancy; Pulmonary Alveoli/*drug effects/embryology/*metabolism; Sodium Channels/metabolism; Sodium-Potassium-Exchanging ATPase/metabolism
Creator
An entity primarily responsible for making the resource
Ye Xin; Acharya Reshma; Herbert Jonathan B; Hamilton Sarah E; Folkesson Hans G
Description
An account of the resource
We tested the hypothesis that interleukin (IL)-1beta-induced cortisol synthesis stimulates alveolar fluid clearance in preterm fetuses. IL-1beta was administered subcutaneously daily to timed-pregnant guinea pigs for 3 days with and without simultaneous cortisol synthesis inhibition by metyrapone. Fetuses were obtained by abdominal hysterotomy at 61 and 68 days gestation and instilled with isosmolar 5% albumin in the lungs, and alveolar fluid movement was measured over 1 h from the change in alveolar protein concentration. Alveolar fluid clearance was induced at 61 days gestation and stimulated at 68 days gestation by IL-1beta, which both were attenuated by cortisol synthesis inhibition. Plasma ACTH and cortisol concentrations were increased by IL-1beta at both gestational ages, and metyrapone reduced cortisol concentrations. IL-1beta was mostly low or undetectable in both fetal and maternal blood. Prenatal alveolar fluid clearance, when present as well as IL-1beta induced, was always propranolol and amiloride sensitive, suggesting that beta-adrenoceptor stimulation and amiloride-sensitive Na+ channels were critical for fluid absorption. IL-1beta increased lung beta-adrenoceptor density at gestation day 61, and cortisol synthesis inhibition attenuated the increased beta-adrenoceptor density. Epithelial Na+ channel and Na+-K+-ATPase subunit expressions were both increased by IL-1beta and attenuated by cortisol synthesis inhibition. These results may explain why babies delivered preterm after intrauterine inflammation have a reduced risk of developing severe respiratory distress.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00214.2003" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00214.2003</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Acharya Reshma
Adrenocorticotropic Hormone/blood
American journal of physiology. Lung cellular and molecular physiology
Animals
Epinephrine/blood
Epithelial Sodium Channels
Extravascular Lung Water/*metabolism
Female
Folkesson Hans G
Guinea Pigs
Hamilton Sarah E
Herbert Jonathan B
Hydrocortisone/blood
Hypothalamo-Hypophyseal System/*physiology
Interleukin-1/blood/*pharmacology
Norepinephrine/blood
Pituitary-Adrenal System/*physiology
Pregnancy
Pulmonary Alveoli/*drug effects/embryology/*metabolism
Sodium Channels/metabolism
Sodium-Potassium-Exchanging ATPase/metabolism
Ye Xin