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Text
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URL Address
<a href="http://doi.org/10.3899/jrheum.130904" target="_blank" rel="noreferrer noopener">http://doi.org/10.3899/jrheum.130904</a>
Pages
938–944
Issue
5
Volume
41
Dublin Core
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Title
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Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.
Publisher
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The Journal of rheumatology
Date
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2014
2014-05
Subject
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Adult; Female; Humans; Male; Middle Aged; Aged; Cross-Sectional Studies; Severity of Illness Index; Biomarkers/blood; Radiography; Human; Cross Sectional Studies; Middle Age; Arthralgia/*diagnostic imaging/*metabolism/physiopathology; BIOMARKERS; Carpometacarpal Joints/diagnostic imaging/metabolism/physiopathology; Finger Joint/diagnostic imaging/metabolism/physiopathology; HAND JOINTS; Hand Joints/*diagnostic imaging/*metabolism/physiopathology; Metacarpophalangeal Joint/diagnostic imaging/metabolism/physiopathology; OSTEOARTHRITIS; Osteoarthritis/*diagnostic imaging/*metabolism/physiopathology; RADIOGRAPHY; Severity of Illness Indices; Osteoarthritis – Physiopathology; Biological Markers – Blood; Arthralgia – Metabolism; Arthralgia – Physiopathology; Arthralgia – Radiography; Carpometacarpal Joints – Metabolism; Carpometacarpal Joints – Physiopathology; Carpometacarpal Joints – Radiography; Finger Joint – Metabolism; Finger Joint – Physiopathology; Finger Joint – Radiography; Hand Joints – Metabolism; Hand Joints – Physiopathology; Hand Joints – Radiography; Metacarpophalangeal Joint – Metabolism; Metacarpophalangeal Joint – Physiopathology; Metacarpophalangeal Joint – Radiography; Osteoarthritis – Metabolism; Osteoarthritis – Radiography
Creator
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Aslam Imran; Perjar Irina; Shi Xiaoyan A; Renner Jordan B; Kraus Virginia B; Golightly Yvonne M; Jordan Joanne M; Nelson Amanda E
Description
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OBJECTIVE: To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade \textgreater/= 2], symptoms, and function. METHODS: Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure involving at least 3 hand joints distributed bilaterally with 2 of 3 in the same joint group, including \textgreater/= 1 distal interphalangeal joint, without metacarpophalangeal (MCP) swelling; (2) rOA in at least 1 joint of a group; and (3) number of joints with KL \textgreater/= 2. We assessed hand symptoms and the 15-item Australian Canadian Hand Osteoarthritis Index (AUSCAN; Likert format). We measured serum cartilage oligomeric matrix protein (sCOMP), hyaluronic acid (sHA), carboxy-terminal propeptide of type II collagen, type II collagen degradation product, urinary C-terminal crosslinked telopeptide of type II collagen, and urinary N-terminal crosslinked telopeptide. Linear regression models were performed to assess associations between each biomarker with hand rOA, AUSCAN, and symptoms, adjusting for age, sex, race, current smoking/drinking status, body mass index, and hip and knee rOA. RESULTS: In adjusted analyses, MCP (p \textless 0.0001) and carpometacarpal rOA (p = 0.003), and a higher number of hand joints with rOA (p = 0.009), were associated with higher levels of sHA. Positive associations were seen between AUSCAN and hand symptoms and levels of sCOMP (p
Identifier
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<a href="http://doi.org/10.3899/jrheum.130904" target="_blank" rel="noreferrer noopener">10.3899/jrheum.130904</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Adult
Aged
Arthralgia – Metabolism
Arthralgia – Physiopathology
Arthralgia – Radiography
Arthralgia/*diagnostic imaging/*metabolism/physiopathology
Aslam Imran
Biological Markers – Blood
Biomarkers
Biomarkers/blood
Carpometacarpal Joints – Metabolism
Carpometacarpal Joints – Physiopathology
Carpometacarpal Joints – Radiography
Carpometacarpal Joints/diagnostic imaging/metabolism/physiopathology
Cross Sectional Studies
Cross-Sectional Studies
Female
Finger Joint – Metabolism
Finger Joint – Physiopathology
Finger Joint – Radiography
Finger Joint/diagnostic imaging/metabolism/physiopathology
Golightly Yvonne M
HAND JOINTS
Hand Joints – Metabolism
Hand Joints – Physiopathology
Hand Joints – Radiography
Hand Joints/*diagnostic imaging/*metabolism/physiopathology
Human
Humans
Jordan Joanne M
Kraus Virginia B
Male
Metacarpophalangeal Joint – Metabolism
Metacarpophalangeal Joint – Physiopathology
Metacarpophalangeal Joint – Radiography
Metacarpophalangeal Joint/diagnostic imaging/metabolism/physiopathology
Middle Age
Middle Aged
Nelson Amanda E
Osteoarthritis
Osteoarthritis – Metabolism
Osteoarthritis – Physiopathology
Osteoarthritis – Radiography
Osteoarthritis/*diagnostic imaging/*metabolism/physiopathology
Perjar Irina
Radiography
Renner Jordan B
Severity of Illness Index
Severity of Illness Indices
Shi Xiaoyan A
The Journal of rheumatology