Browse Items · NEOMED Bibliography Database

MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1beta-stimulated human chondrocytes.

OBJECTIVE: Enhanced expression of interleukin-6 (IL-6) plays an important role in the pathogenesis of osteoarthritis (OA). Monocyte chemoattractant protein-induced protein 1 (MCPIP-1) is a novel posttranscriptional regulator of IL-6 expression and is…

Tags: 2015, Academic Medical Centers, Aged, Arthritis & rheumatology (Hoboken, N.J.), Articular/drug effects/*metabolism, Cartilage, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism, Cultured, Department of Anatomy & Neurobiology, Enzyme-Linked Immunosorbent Assay, Funding Source, Gene Knockdown Techniques, Haqqi Tariq M, Haseeb Abdul, Hip/*genetics/metabolism, Human, Humans, Immunoblotting – Utilization, Immunoprecipitation, Interleukin-1beta/pharmacology, Interleukin-6/*genetics/metabolism, Interleukins – Physiology, Makki Mohammad S, Messenger/drug effects/*metabolism, MicroRNAs/drug effects/*genetics/metabolism, Middle Aged, NEOMED College of Medicine, Ohio, Osteoarthritis, Osteoarthritis – Complications, Osteoarthritis – Physiopathology, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleases/drug effects/*genetics/metabolism, RNA, T-Tests, Transcription Factors/drug effects/*genetics/metabolism

Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.

There is growing evidence in support of the involvement of inflammatory response in the pathogenesis of osteoarthritis (OA). Harpagoside, one of the bioactive components of Harpagophytum procumbens (Hp), has been shown to possess anti-inflammatory…

Tags: *c-FOS/AP-1, *harpagoside, *IL-6, *MMP-13, *OSTEOARTHRITIS, 2017, Ansari Mohammad Yunus, CCAAT-Enhancer-Binding Protein-beta/metabolism, Chemokines/metabolism, Chondrocytes/*drug effects/metabolism, Department of Anatomy & Neurobiology, Drug Evaluation, Glycosides/pharmacology/*therapeutic use, Haqqi Tariq M, Harpagophytum, Haseeb Abdul, Humans, Interleukin-1beta, Interleukin-6/antagonists & inhibitors/*metabolism, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Matrix Metalloproteinase 13/metabolism, NEOMED College of Medicine, NF-kappa B/metabolism, Osteoarthritis/*drug therapy/metabolism, Phytotherapy, Plant Extracts/pharmacology/therapeutic use, Preclinical, Primary Cell Culture, Proto-Oncogene Proteins c-fos/metabolism, Pyrans/pharmacology/*therapeutic use, Reactive Oxygen Species/metabolism, Transcription Factor AP-1/metabolism

A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.

Pomegranate fruit extract (PE) rich in polyphenols has been shown to exert chondroprotective effects, but the mechanism is not established. Here, we used an in vitro model of inflammation in osteoarthritis (OA) to investigate the potential of PE to…

Tags: 2017, Ashruf Omer S, Chondrocytes, Chondrocytes – Drug Effects, Chondrocytes/drug effects, Department of Anatomy & Neurobiology, Fruit, Fruit/chemistry, Gene Expression Regulation/drug effects, Genes – Drug Effects, Haqqi Tariq M, Haseeb Abdul, Humans, I-kappa B Kinase/genetics/*metabolism, IkappaB, IKKbeta, IL-1beta, Interleukin 1 – Metabolism, Interleukin-1beta/metabolism, Interleukin-6/genetics/*metabolism, Interleukins, Interleukins – Metabolism, Khan Nazir M, NEOMED College of Medicine, NF-kappa B, NF-kappa B – Metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, NIK, Osteoarthritis, Phosphorylation – Drug Effects, Phosphorylation/drug effects, Phytotherapy research : PTR, Plant Extracts, Plant Extracts – Pharmacodynamics, Plant Extracts/chemistry/*pharmacology, Polyphenols – Pharmacodynamics, Polyphenols/pharmacology, Pomegranate, Protein-Serine-Threonine Kinases/genetics/*metabolism, Proteins – Metabolism, Punicaceae/*chemistry, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Transcription Factor RelA/metabolism, Transferases, Transferases – Metabolism

Identification of plasma microRNA expression profile in radiographic axial spondyloarthritis-a pilot study.

At present, there are no studies that have established a microRNA (miRNA)-based signature profile in patients with radiographic axial spondyloarthritis (rad-axial SpA), and we hypothesized that these patients may have aberrantly expressed circulating…

Immunopathogenesis of osteoarthritis.

Even though osteoarthritis (OA) is mainly considered as a degradative condition of the articular cartilage, there is increasing body of data demonstrating the involvement of all branches of the immune system. Genetic, metabolic or mechanical factors…

Tags: 2013, Adaptive Immunity, Animals, Clinical immunology (Orlando, Fla.), Department of Anatomy & Neurobiology, Haqqi Tariq M, Haseeb Abdul, Humans, Immunity, Innate, NEOMED College of Medicine, Osteoarthritis/*immunology, Signal Transduction

Dataset of effect of Wogonin, a natural flavonoid, on the viability and activation of NF-kappaB and MAPKs in IL-1beta-stimulated human OA chondrocytes.

This article contains data related to the article "Wogonin, a plant derived small molecule exerts potent anti-inflammatory and chondroprotective effects through activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes" (Khan…

Tags: 2017, Ansari Mohammad Y, Data in brief, Department of Anatomy & Neurobiology, Devarapalli Pratap, Haqqi Tariq M, Haseeb Abdul, Haynie Sara, Khan Nazir M, MAPK, Mass-spectrometry, NEOMED College of Medicine, NF-kappaB, Nrf2, Osteoarthritis, Wogonin

Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.

Osteoarthritis (OA), characterized by progressive destruction of articular cartilage, is the most common form of human arthritis. Here, we evaluated the potential chondroprotective and anti-inflammatory effects of Wogonin, a naturally occurring…

Tags: *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, *Wogonin, 2017, Ansari Mohammad Y, Anti-Inflammatory Agents/administration & dosage, Chondrocytes/drug effects/pathology, Department of Anatomy & Neurobiology, Devarapalli Pratap, Flavanones/*administration & dosage, Free radical biology & medicine, Gene Expression Regulation/drug effects, Haqqi Tariq M, Haseeb Abdul, Haynie Sara, Humans, Inflammation/*drug therapy/metabolism/pathology, Kelch-Like ECH-Associated Protein 1/chemistry/*genetics/metabolism, Khan Nazir M, MAP Kinase Signaling System/drug effects, Molecular Docking Simulation, NEOMED College of Medicine, NF-E2-Related Factor 2/antagonists & inhibitors/chemistry/*genetics/metabolism, Osteoarthritis/*drug therapy/metabolism/pathology, Protein Binding, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects

Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes.

MicroRNAs, a group of small, noncoding RNAs that post-transcriptionally regulate gene expression, play important roles in chondrocyte function and in the development of osteoarthritis. We characterized the dynamic repertoire of the chondrocyte…

Tags: 2017, Ahmad Imran, Department of Anatomy & Neurobiology, Haqqi Tariq M, Haseeb Abdul, Khan Nazir M, Makki Mohammad Shahidul, NEOMED College of Medicine, Scientific reports

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1beta-induced activation of AP-1 in human OA chondrocytes.

Osteoarthritis (OA) is a common joint disorder with varying degrees of inflammation and sustained oxidative stress. The root extract of Scutellaria baicalensis (SBE) has been used for the treatment of inflammatory and other diseases. Here, we…

Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.

5-Hydroxymethylcytosine (5-hmC) generated by ten-eleven translocation 1-3 (TET1-3) enzymes is an epigenetic mark present in many tissues with different degrees of abundance. IL-1beta and TNF-alpha are the two major cytokines present in arthritic…

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