1
40
5
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1369/jhc.4A6455.2004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1369/jhc.4A6455.2004</a>
Pages
1665–1674
Issue
12
Volume
52
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening.
Publisher
An entity responsible for making the resource available
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-12
Subject
The topic of the resource
Female; Animals; Immunohistochemistry; Pregnancy; Rats; Microcirculation; Phosphorylation; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Reverse Transcriptase Polymerase Chain Reaction; Cervical Ripening/*metabolism; Cervix Uteri/blood supply/innervation/*metabolism; Denervation; Nitric Oxide Synthase Type III; Nitric Oxide Synthase/biosynthesis; Protein Isoforms/biosynthesis/metabolism; Protein-Serine-Threonine Kinases/biosynthesis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins/biosynthesis; Vascular Endothelial Growth Factor A/biosynthesis/*metabolism; Vascular Endothelial Growth Factor Receptor-2/biosynthesis; Wistar; Animal/*metabolism
Creator
An entity primarily responsible for making the resource
Mowa C N; Jesmin S; Sakuma I; Usip S; Togashi H; Yoshioka M; Hattori Y; Papka R
Description
An account of the resource
Bilateral neurectomy of the pelvic nerve (BLPN) that carries uterine cervix-related sensory nerves induces dystocia, and administration of its vasoactive neuropeptides induces changes in the cervical microvasculature, resembling those that occur in the ripening cervix. This study was designed to test the hypothesis that (a) the cervix of pregnant rats expresses vascular endothelial growth factor (VEGF) and components of the angiogenic signaling pathway [VEGF receptors (Flt-1, KDR), activity of protein kinase B, Akt (phosphorylated Akt), and endothelial nitric oxide synthase (eNOS)] and von Willebrand Factor (vWF) and that these molecules undergo changes with pregnancy, and (b) bilateral pelvic neurectomy (BLPN) alters levels of VEGF concentration in the cervix. Using RT-PCR and sequencing, two VEGF isoforms, 120 and 164, were identified in the rat cervix. VEGF, VEGF receptor-1 (Flt-1), eNOS, and vWF immunoreactivities (ir) were localized in the microvasculature of cervical stroma. Their protein levels increased during pregnancy but decreased to control levels by 2 days postpartum. VEGF receptor-2 (KDR)-ir was confined to the epithelium of the endocervix. BLPN downregulated levels of VEGF by a third. Therefore, the components of the angiogenic signaling pathway are expressed in the cervix and change over pregnancy. Furthermore, angiogenic and sensory neuronal factors may be important in regulating the dynamic microvasculature in the ripening cervix and may subsequently play a role in cervical ripening and the birth process.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1369/jhc.4A6455.2004" target="_blank" rel="noreferrer noopener">10.1369/jhc.4A6455.2004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Animal/*metabolism
Animals
Cervical Ripening/*metabolism
Cervix Uteri/blood supply/innervation/*metabolism
Denervation
Department of Anatomy & Neurobiology
Down-Regulation
Enzyme-Linked Immunosorbent Assay
Female
Hattori Y
Immunohistochemistry
Jesmin S
Microcirculation
Mowa C N
NEOMED College of Medicine
Nitric Oxide Synthase Type III
Nitric Oxide Synthase/biosynthesis
Papka R
Phosphorylation
Pregnancy
Protein Isoforms/biosynthesis/metabolism
Protein-Serine-Threonine Kinases/biosynthesis
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins/biosynthesis
Rats
Reverse Transcriptase Polymerase Chain Reaction
Sakuma I
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Togashi H
Usip S
Vascular Endothelial Growth Factor A/biosynthesis/*metabolism
Vascular Endothelial Growth Factor Receptor-2/biosynthesis
Wistar
Yoshioka M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S23-S23
Volume
52
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Denervation of uterine cervix-related sensory nerves down-regulates levels of VEGF in the rat cervix at parturition
Publisher
An entity responsible for making the resource available
Journal of Histochemistry & Cytochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-07
Subject
The topic of the resource
Cell Biology
Creator
An entity primarily responsible for making the resource
Mowa C N; Jesmin S; Sakuma I; Hattori Y; Usip S; Papka R
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2004
Cell Biology
Hattori Y
Jesmin S
Journal Article
Journal of Histochemistry & Cytochemistry
Mowa C N
Papka R
Sakuma I
Usip S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S51-S51
Volume
52
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The penis is a target and producer of estrogen: Evidence of presence of an estrogen-ER system
Publisher
An entity responsible for making the resource available
Journal of Histochemistry & Cytochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-07
Subject
The topic of the resource
Cell Biology
Creator
An entity primarily responsible for making the resource
Mowa C N; Jesmin S; Hattori Y; Sakuma I
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2004
Cell Biology
Hattori Y
Jesmin S
Journal Article
Journal of Histochemistry & Cytochemistry
Mowa C N
Sakuma I
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1677/jme.101548" target="_blank" rel="noreferrer noopener">http://doi.org/10.1677/jme.101548</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
343-359
Issue
2
Volume
33
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aromatase Is Abundantly Expressed By Neonatal Rat Penis But Downregulated In Adulthood
Publisher
An entity responsible for making the resource available
Journal of Molecular Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-10
Subject
The topic of the resource
androgen receptor; beta messenger-rnas; brain; cytochrome-p450 aromatase; Endocrinology & Metabolism; estrogen-receptor-alpha; female reproductive organ; in-situ hybridization; leydig-cells; ribonucleic-acid; tract
Creator
An entity primarily responsible for making the resource
Jesmin S; Mowa C N; Sakuma I; Matsuda N; Togashi H; Yoshioka M; Hattori Y; Kitabatake A
Description
An account of the resource
Although synthesis of estrogen by male gonads has been well documented for over half a century, it is only recently that the role of estrogen in male reproductive events has gained appreciation. We recently reported abundant expression of estrogen receptor (ER)-alpha and -beta in different cell types of the rat penis, whose levels diminished with advancing age. The present study, which builds on data from the ER study, was designed to determine whether the penis is capable of generating its own local estrogen by examining evidence of the expression of aromatase, a microsomal enzymatic complex which irreversibly converts androgens to estrogens, using immunohistochemistry, Western blotting, in situ hybridization and real-time PCR analyses. Secondly, the effects of sex steroid hormones on penile aromatase were examined. Discrete aromatase immunoreactive cells were localized in primordial corpus cavernosum, corpus spongiosus and os penis, blood vessels and sensory corpuscle of glans penis. In situ hybridization signals corresponded with immunohistochemical findings. Western blot, enzyme immunoassay and real-time PCR analyses of rat penile samples revealed an age-dependent expression of aromatase and estrogen, with levels at week 1 almost resembling those of the ovary, but they decreased sharply by week 8, and decreased further by week 35. This expression pattern was strikingly similar to that of ER-alpha reported previously. Testosterone and diethylstilbesterol administered prenatally upregulate levels of aromatase mRNA and protein, and estrogen postnatally. Dihydrotestosterone upregulated aromatase mRNA and protein, but not estrogen. We conclude that estrogen acts via ER in a paracrine and/or autocrine manner to regulate penile events, particularly during development, and that estrogen synthesis is regulated by estrogen and androgens.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1677/jme.101548" target="_blank" rel="noreferrer noopener">10.1677/jme.101548</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
androgen receptor
beta messenger-rnas
Brain
cytochrome-p450 aromatase
Endocrinology & Metabolism
estrogen-receptor-alpha
female reproductive organ
Hattori Y
in-situ hybridization
Jesmin S
Journal Article or Conference Abstract Publication
Journal of Molecular Endocrinology
Kitabatake A
leydig-cells
Matsuda N
Mowa C N
ribonucleic-acid
Sakuma I
Togashi H
tract
Yoshioka M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1210/en.2002-220628" target="_blank" rel="noreferrer noopener">http://doi.org/10.1210/en.2002-220628</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4764-4774
Issue
12
Volume
143
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evidence For A Potential Role Of Estrogen In The Penis: Detection Of Estrogen Receptor-alpha And -beta Messenger Ribonucleic Acid And Protein
Publisher
An entity responsible for making the resource available
Endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
androgen receptor; differential expression; dorsal-root ganglion; Endocrinology & Metabolism; hyena crocuta-crocuta; in-situ hybridization; male reproductive-system; molecular-cloning; rat pituitary; sexual-behavior; spinal-cord
Creator
An entity primarily responsible for making the resource
Jesmin S; Mowa C N; Matsuda N; Salah-Eldin A E; Togashi H; Sakuma I; Hattori Y; Kitabatake A
Description
An account of the resource
Body tissues are traditionally classified as estrogen targets based on both the response to the hormone and the presence of estrogen receptors (ERs). We undertook the study on expression of ERalpha and ERbeta in the penis to identify compartments/cells responsive to estrogen, using immunohistochemistry, Western blotting, in situ hybridization, and RT-PCR analyses. Expressions of ERalpha and ERbeta in the rat penis were age dependent at both mRNA and protein levels, with the most intense signals being observed during the perinatal period and declining thereafter with age. Initial signals (fetal d 17) of ERalpha were localized to the mesenchyme and subepithelial stroma and later (postnatal d 2) to the corpus spongiosus, corpus cavernosus; and urethral epithelia. ERbeta was initially detected by postnatal d 2 and was localized diffusely in corpus spongiosus and cavernosus in immature rats. In the. adult, both ERs were concentrated largely to the urethral eithelia and vascular and neuronal structures. The present study provides the first evidence for ER expression in the penis. Thus, our data add the penis to the list of estrogen-responsive tissues in males and provide a base and insight for future studies aimed at investigating a functional role of estrogen in the penis, especially in development.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1210/en.2002-220628" target="_blank" rel="noreferrer noopener">10.1210/en.2002-220628</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2002
androgen receptor
differential expression
dorsal-root ganglion
Endocrinology
Endocrinology & Metabolism
Hattori Y
hyena crocuta-crocuta
in-situ hybridization
Jesmin S
Journal Article or Conference Abstract Publication
Kitabatake A
male reproductive-system
Matsuda N
molecular-cloning
Mowa C N
rat pituitary
Sakuma I
Salah-Eldin A E
sexual-behavior
spinal-cord
Togashi H