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Text
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URL Address
<a href="http://doi.org/10.1016/s0272-6386(98)70042-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0272-6386(98)70042-3</a>
Pages
E4–E4
Issue
4
Volume
32
Dublin Core
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Title
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Cyclosporine disposition and long-term renal function in a 500-pound kidney transplant recipient.
Publisher
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American journal of kidney diseases : the official journal of the National Kidney Foundation
Date
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1998
1998-10
Subject
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Biological Availability; Cadaver; Chronic/surgery; Cyclosporine/administration & dosage/*pharmacokinetics; Diabetes Mellitus; Diabetic Nephropathies/surgery; Humans; Immunosuppressive Agents/administration & dosage/*pharmacokinetics; Injections; Intravenous; Kidney Failure; Kidney Function Tests; Kidney Transplantation/*physiology; Male; Middle Aged; Morbid/etiology/*physiopathology; Obesity; Type 1/complications
Creator
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Flechner S M; Haug M; Fisher R K; Modlin C S
Description
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Patient size has been suggested as a risk factor in kidney transplantation. We have followed a recipient of a cadaver kidney who became massively obese (232 kg, 511 lbs) 5 years posttransplantation. He has maintained stable renal function with no rejection episodes and at 5 years has a measured serum creatinine of 2.2 mg/dL, creatinine clearance 42 mL/min, and urinary protein excretion of 320 mg/24h. Both oral and intravenous cyclosporine (Sandimmune) pharmacokinetic studies were done on a steady-state dose of 150 mg, which represents 0.65 mg/kg per dose. The patient exhibited very high bioavailability, F = 95%, and an oral elimination T1/2 of over 21 hours. These data confirm that stable cyclosporine delivery in very obese recipients can be sustained by dosing normalized to the ideal body weight and trough level monitoring.
Identifier
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<a href="http://doi.org/10.1016/s0272-6386(98)70042-3" target="_blank" rel="noreferrer noopener">10.1016/s0272-6386(98)70042-3</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
American journal of kidney diseases : the official journal of the National Kidney Foundation
Biological Availability
Cadaver
Chronic/surgery
Cyclosporine/administration & dosage/*pharmacokinetics
Diabetes Mellitus
Diabetic Nephropathies/surgery
Fisher R K
Flechner S M
Haug M
Humans
Immunosuppressive Agents/administration & dosage/*pharmacokinetics
Injections
Intravenous
Kidney Failure
Kidney Function Tests
Kidney Transplantation/*physiology
Male
Middle Aged
Modlin C S
Morbid/etiology/*physiopathology
Obesity
Type 1/complications