1
40
21
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.heares.2020.107896" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2020.107896</a>
Pages
107896-107896
Volume
388
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Generation of a ChAT(Cre) mouse line without the early onset hearing loss typical of the C57BL/6J strain.
Publisher
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Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03
Subject
The topic of the resource
Acetylcholine; Age-related hearing loss; Presbycusis; Choline acetyltransferase; Normal hearing; Transgenic mouse
Creator
An entity primarily responsible for making the resource
Beebe Nichole L; Sowick Colleen S; Kristaponyte Inga; Galazyuk Alexander V; Vetter Douglas E; Cox Brandon C; Schofield Brett R
Description
An account of the resource
The development of knockin mice with Cre recombinase expressed under the control of the promoter for choline acetyltransferase (ChAT) has allowed experimental manipulation of cholinergic circuits. However, currently available ChAT(Cre) mouse lines are on the C57BL/6J strain background, which shows early onset age-related hearing loss attributed to the Cdh23(753A) mutation (a.k.a., the ahl mutation). To develop ChAT(Cre) mice without accelerated hearing loss, we backcrossed ChAT(IRES-Cre) mice with CBA/CaJ mice that have normal hearing. We used genotyping to obtain mice homozygous for ChAT(IRES-Cre) and the wild-type allele at the Cdh23 locus (ChAT(Cre,Cdh23WT)). In the new line, auditory brainstem response thresholds were approximately 20 dB lower than those in 9 month old ChAT(IRES-Cre) mice at all frequencies tested (4-31.5 kHz). These thresholds were stable throughout the period of testing (3-12 months of age). We then bred ChAT(Cre,Cdh23WT) animals with Ai14 reporter mice to confirm the expression pattern of ChAT(Cre). In these mice, tdTomato-labeled cells were observed in all brainstem regions known to contain cholinergic cells. We then stained the tissue with a neuron-specific marker, NeuN, to determine whether Cre expression was limited to neurons. Across several brainstem nuclei (pontomesencephalic tegmentum, motor trigeminal and facial nuclei), 100% of the tdTomato-labeled cells were double-labeled with anti-NeuN (n = 1896 cells), indicating Cre-recombinase was limited to neurons. Almost all of these cells (1867/1896 = 98.5%) also stained with antibodies against ChAT, indicating that reporter label was expressed almost exclusively in cholinergic neurons. Finally, an average 88.7% of the ChAT+ cells in these nuclei were labeled with tdTomato, indicating that the Cre is expressed in a large proportion of the cholinergic cells in these nuclei. We conclude that the backcrossed ChAT(Cre,Cdh23WT) mouse line has normal hearing and expresses Cre recombinase almost exclusively in cholinergic neurons. This ChAT(Cre,Cdh23WT) mouse line may provide an opportunity to manipulate cholinergic circuits without the confound of accelerated hearing loss associated with the C57BL/6J background. Furthermore, comparison with lines that do show early hearing loss may provide insight into possible cholinergic roles in age-related hearing loss.
Identifier
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<a href="http://doi.org/10.1016/j.heares.2020.107896" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2020.107896</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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Journal Article
2020
Acetylcholine
Age-related hearing loss
Beebe Nichole L
Choline acetyltransferase
Cox Brandon C
Department of Anatomy & Neurobiology
Galazyuk Alexander V
Hearing research
Kristaponyte Inga
NEOMED College of Medicine
Normal hearing
Presbycusis
Schofield Brett R
Sowick Colleen S
Transgenic mouse
Vetter Douglas E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0378-5955(01)00333-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-5955(01)00333-1</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
58-62
Issue
1
Volume
160
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Frequency sensitivity range of the saccule to bone-conducted stimuli measured by vestibular evoked myogenic potentials
Publisher
An entity responsible for making the resource available
Hearing Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-10
Subject
The topic of the resource
Audiology & Speech-Language Pathology; bone conduction; frequency sensitivity range; myogenic potential; nerve; neurons; Neurosciences & Neurology; Otorhinolaryngology; repetition rate; responses; saccule; sound; squirrel-monkey; vestibular; vestibular evoked myogenic potential; vibration
Creator
An entity primarily responsible for making the resource
Sheykholeslami K; Kermany M H; Kaga K
Description
An account of the resource
Vestibular evoked myogenic potentials (VEMPs) occurring in cervical muscles after intense sound stimulation conducted by air or bone are thought to be a polysynaptic response of otolith-vestibular nerve origin. We report the results of an experiment to investigate whether acoustic stimulation of the saccule by bone conduction produces VEMPs in which response amplitudes are somewhat sensitive to stimulus frequency, as appears, to be the case with air-conducted stimuli. Prior to this we investigated the effect of stimulation repetition rate on bone-conducted VEMPs (B-VEMPs) at stimulus frequencies of 200 and 400 Hz with five different repetition rates (5, 10, 20, 40, and 80 Hz). B-VEMPs were recorded from 12 normal hearing subjects in response to bone-conducted 70 dB (normal hearing level), 10-ms tone bursts (rise/fall time = 1 ms and plateau time = 8 ms) at frequencies of 100, 200, 400, 800, 1600 and 3200 Hz. Our study showed that B-VEMP amplitudes were highest at 10 Hz but decreased as the repetition rate increased. B-VEMP response amplitudes were found to be maximal for stimulus frequencies from 200 to 400 Hz. This response may contribute to the perception of loud sounds. (C) 2001 Elsevier Science B.V. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/s0378-5955(01)00333-1" target="_blank" rel="noreferrer noopener">10.1016/s0378-5955(01)00333-1</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
Audiology & Speech-Language Pathology
Bone Conduction
frequency sensitivity range
Hearing research
Journal Article
Kaga K
Kermany M H
myogenic potential
nerve
Neurons
Neurosciences & Neurology
Otorhinolaryngology
repetition rate
responses
saccule
Sheykholeslami K
Sound
squirrel-monkey
vestibular
vestibular evoked myogenic potential
vibration
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2018.10.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2018.10.001</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-10
Volume
376
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Subtypes of GABAergic cells in the inferior colliculus
Publisher
An entity responsible for making the resource available
Hearing Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-05
Subject
The topic of the resource
Auditory system; Cell type; GABA; Inhibition; Perineuronal net
Creator
An entity primarily responsible for making the resource
Schofield Brett R; Beebe Nichole L
Description
An account of the resource
The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physiology, molecular markers - indicate that the GABAergic cells can be divided into at least four subtypes that serve different functions. However, there has yet to emerge a unified scheme for distinguishing these subtypes. The present review discusses these criteria and, where possible, relates the different properties. In contrast to GABAergic cells in cerebral cortex, where subtypes are much more thoroughly characterized, those in the inferior colliculus contribute substantially to numerous long range extrinsic projections. At present, the best characterized subtype is a GABAergic cell with a large soma, dense perisomatic synaptic inputs and a large axon that provides rapid auditory input to the thalamus. This large GABAergic subtype projects to additional targets, and other subtypes also project to the thalamus. The eventual characterization of these subtypes can be expected to reveal multiple functions of these inhibitory cells and the many circuits to which they contribute.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2018.10.001" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2018.10.001</a>
2019
Auditory system
Beebe Nichole L
Cell type
Department of Anatomy & Neurobiology
GABA
Hearing research
inhibition
June 2019 Update
NEOMED College of Medicine
perineuronal net
Schofield Brett R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2019.01.022" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2019.01.022</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-13
Volume
375
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology; NEOMED Postdoc Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Residual inhibition: From the putative mechanisms to potential tinnitus treatment.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-04
Creator
An entity primarily responsible for making the resource
Galazyuk A V; Longenecker R J; Voytenko S V; Kristaponyte I; Nelson G L
Description
An account of the resource
Neurons in various sensory systems show some level of spontaneous firing in the absence of sensory stimuli. In the auditory system spontaneous firing has been shown at all levels of the auditory pathway from spiral ganglion neurons in the cochlea to neurons of the auditory cortex. This internal "noise" is normal for the system and it does not interfere with our ability to perceive silence or analyze sound. However, this internal noise can be elevated under pathological conditions, leading to the perception of a phantom sound known as tinnitus. The efforts of many research groups, including our own, led to the development of a mechanistic understanding of this process: After cochlear insult the input to the central auditory system becomes markedly reduced. As a result, the neural activity in the central auditory system is enhanced to compensate for this reduced input. Such hyperactivity is hypothesized to be interpreted by the brain as a presence of sound. This implies that suppression of hyperactivity should reduce/eliminate tinnitus. This review explores research from our laboratory devoted to identifying the mechanism underlying residual inhibition of tinnitus, a brief suppression of tinnitus following a sound stimulus. The key mechanisms that govern neural suppression of spontaneous activity in animals closely resemble clinical psychoacoustic findings of residual inhibition (RI) observed in tinnitus patients. This suppression is mediated by metabotropic glutamate receptors (mGluRs). Lastly, drugs targeting mGluRs suppress spontaneous activity in auditory neurons and reduce/eliminate behavioral signs of tinnitus in mice. Thus, these drugs are therapeutically relevant for tinnitus suppression in humans.
Identifier
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<a href="http://doi.org/10.1016/j.heares.2019.01.022" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2019.01.022</a>
2019
Department of Anatomy & Neurobiology
Galazyuk A V
Hearing research
Kristaponyte I
Longenecker R J
Nelson G L
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
Voytenko S V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/S0378-5955(04)00018-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/S0378-5955(04)00018-8</a>
Pages
161–168
Issue
1
Volume
190
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Vestibular-evoked myogenic potentials in three patients with large vestibular aqueduct.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
Adult; Auditory Threshold/*physiology; Auditory/*physiology; Bilateral/diagnosis/etiology; Child; Evoked Potentials; Female; Hearing Loss; Humans; Preschool; Saccule and Utricle/*physiopathology; Sensorineural/diagnosis/etiology; Tomography; Vestibular Aqueduct/*abnormalities/*physiopathology; Vestibular Diseases/complications/congenital/*physiopathology; Vestibular Function Tests; X-Ray Computed
Creator
An entity primarily responsible for making the resource
Sheykholeslami Kianoush; Schmerber Sebastien; Habiby Kermany Mohammad; Kaga Kimitaka
Description
An account of the resource
An enlarged vestibular aqueduct (LVA) is a common congenital inner ear anomaly responsible for some unusual vestibular and audiological symptoms. Most of the cases show bilateral early onset and progressive hearing loss in children. The gross appearance on CT scan of the inner ear is generally normal. However, precise measurements of the inner ear components reveal abnormal dimensions, which may account for the accompanying auditory and vestibular dysfunction. Despite extensive studies on hearing and the vestibular apparatus, saccular function is not studied. To our knowledge this is the first report of saccular malfunction in three patients with LVA by means of vestibular evoked myogenic potentials. Conventional audiograms revealed bilateral severe sensorineural hearing loss in two patients and mixed type hearing loss in one patient. Two of the patients complained about vertigo and dizziness but vestibular assessments of the patients showed normal results. The diagnosis had been made by high-resolution CT scans and MR images of the skull that showed LVA in the absence of other anomalies. The VEMP threshold measured from the ear with LVA in two patients with unilateral enlargement of the vestibular aqueduct was 75-80 dB nHL whereas the threshold from normal ears was 95 dB nHL. The third patient with mixed type hearing loss and bilateral LVA had VEMP responses despite a big air-bone gap in the low frequency range. The VEMP in this patient was greater in amplitude and lower in threshold in the operated ear (the patient had a tympanoplasty which did not improve her hearing). These findings and results of other patients with Tullio phenomenon and superior semicircular canal dehiscence, who also showed lower VEMP threshold, confirmed the theory of a 'third window' that allows volume and pressure displacements, and thus larger deflection of the vestibular sensors, which would cause the vestibular organ to be more responsive to sound and pressure changes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/S0378-5955(04)00018-8" target="_blank" rel="noreferrer noopener">10.1016/S0378-5955(04)00018-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Adult
Auditory Threshold/*physiology
Auditory/*physiology
Bilateral/diagnosis/etiology
Child
Evoked Potentials
Female
Habiby Kermany Mohammad
Hearing Loss
Hearing research
Humans
Kaga Kimitaka
Preschool
Saccule and Utricle/*physiopathology
Schmerber Sebastien
Sensorineural/diagnosis/etiology
Sheykholeslami Kianoush
Tomography
Vestibular Aqueduct/*abnormalities/*physiopathology
Vestibular Diseases/complications/congenital/*physiopathology
Vestibular Function Tests
X-Ray Computed
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0378-5955(02)00376-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-5955(02)00376-3</a>
Pages
131–138
Issue
1
Volume
168
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Excitatory and facilitatory frequency response areas in the inferior colliculus of the mustached bat.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-06
Subject
The topic of the resource
Acoustic Stimulation; Animal; Animals; Auditory; Auditory Perception/*physiology; Brain Stem; Chiroptera/*physiology; Echolocation; Evoked Potentials; Inferior Colliculi/*physiology; Neurons/physiology; Vocalization
Creator
An entity primarily responsible for making the resource
Portfors Christine V; Wenstrup Jeffrey J
Description
An account of the resource
In the mustached bat's central nucleus of the inferior colliculus (ICC), many neurons display facilitatory or inhibitory responses when presented with two tones of distinctly different frequencies. Our previous studies have focused on spectral interactions between specific frequency bands contained in the bat's sonar vocalization. In this study, we describe excitatory and facilitatory frequency response areas across all frequencies in the mustached bat's audible range. We show that many neurons in the ICC have more extensive frequency interactions than previously documented. We recorded responses of 96 single units to single tones and combinations of two tones. Best frequencies of the units ranged from 59-15 kHz. Forty-one units had a single, excitatory frequency response area. The rest of the units had more complex frequency tuning that included multiple excitatory frequency response areas and facilitatory frequency response areas. Some of the facilitatory frequency interactions were between one sound with energy in a sonar frequency band and a second sound with energy in a non-sonar frequency band. We also found that neurons could be facilitated by more than one additional frequency band. Our findings of extensive frequency interactions in the ICC of the mustached bat suggest that some neurons may be well suited for the analysis of complex sounds, possibly including social communication sounds.
Identifier
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<a href="http://doi.org/10.1016/s0378-5955(02)00376-3" target="_blank" rel="noreferrer noopener">10.1016/s0378-5955(02)00376-3</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Acoustic Stimulation
Animal
Animals
Auditory
Auditory Perception/*physiology
Brain Stem
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation
Evoked Potentials
Hearing research
Inferior Colliculi/*physiology
NEOMED College of Medicine
Neurons/physiology
Portfors Christine V
Vocalization
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0378-5955(02)00278-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-5955(02)00278-2</a>
Pages
62–67
Issue
1
Volume
165
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The otolithic organ as a receptor of vestibular hearing revealed by vestibular-evoked myogenic potentials in patients with inner ear anomalies.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-03
Subject
The topic of the resource
Adolescent; Adult; Audiometry; Auditory Threshold; Bone Conduction; Child; Cochlea/abnormalities/diagnostic imaging; Cochlear Diseases/complications/diagnostic imaging/*physiopathology; Deafness/etiology; Evoked Potentials; Female; Hearing/*physiology; Humans; Labyrinth/*physiopathology; Male; Neck Muscles/*physiopathology; Otolithic Membrane/*physiopathology; Preschool; Pure-Tone; Reaction Time; Saccule and Utricle/physiopathology; Tomography; Vestibule; X-Ray Computed
Creator
An entity primarily responsible for making the resource
Sheykholeslami Kianoush; Kaga Kimitaka
Description
An account of the resource
The human vestibule has preserved an ancestral sound sensitivity and it has been suggested that a reflex could originate from this property underlying cervical muscle micro-contractions secondary to strong acoustic stimulation. Previous studies have established that an early component of loud sound-evoked myogenic potentials from the sternocleidomastoid muscle originate in the vestibule. This is based on findings that the response can still be obtained from patients with complete loss of cochlear and vestibular (semi-circular canal) function. Our data confirm, in a more direct way, a saccular origin of this short-latency acoustic response and verifies that a saccular acoustic response persists in the human ear. The contribution of this response to the perception of loud sounds is discussed. It is concluded that vestibular response to sound might be used to assist in the rehabilitation of deafness.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0378-5955(02)00278-2" target="_blank" rel="noreferrer noopener">10.1016/s0378-5955(02)00278-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Adolescent
Adult
Audiometry
Auditory Threshold
Bone Conduction
Child
Cochlea/abnormalities/diagnostic imaging
Cochlear Diseases/complications/diagnostic imaging/*physiopathology
Deafness/etiology
Evoked Potentials
Female
Hearing research
Hearing/*physiology
Humans
Kaga Kimitaka
Labyrinth/*physiopathology
Male
Neck Muscles/*physiopathology
Otolithic Membrane/*physiopathology
Preschool
Pure-Tone
Reaction Time
Saccule and Utricle/physiopathology
Sheykholeslami Kianoush
Tomography
Vestibule
X-Ray Computed
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0378-5955(01)00326-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-5955(01)00326-4</a>
Pages
117–124
Issue
1
Volume
159
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Auditory nerve fiber differences in the normal and neurofilament deficient Japanese quail.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-09
Subject
The topic of the resource
*Mutation; Animals; Auditory; Axons/ultrastructure; Brain Stem; Cochlear Nerve/*pathology/*physiopathology; Coturnix/genetics; Electron; Evoked Potentials; Microscopy; Myelin Sheath/ultrastructure; Nerve Fibers/pathology/physiology; Neurofilament Proteins/*deficiency/*genetics
Creator
An entity primarily responsible for making the resource
Sheykholeslami K; Kaga K; Mizutani M
Description
An account of the resource
A primary axonal disease affecting the central and peripheral nervous system was discovered in a mutant strain of the Japanese quail, named quiver (Quv). We have previously demonstrated altered auditory evoked potentials in the neurofilament (NF) deficient quail. In this current study we attempt to find relationships between the auditory evoked potential results and the histo-pathological abnormalities of the auditory neurons. No abnormalities in the external auditory meatus and tympanic cavity were observed in either Quv or control quails and the ganglion cell bodies and their nuclei appeared normal by light microscopy. The myelin staining pattern was found to be similar in both strains with hematoxylin and eosin and Kluver-Barrera staining. The frequency histograms of fiber and axonal diameters of myelinated fibers showed an unimodal pattern in both strains. In Quv quails myelinated fibers and their axoplasm were smaller in diameter than in controls resulting in smaller neural tissue mass. In electron microscopic observation the axons of the Quv quail were composed of mitochondria and microtubules and smooth endoplasmic reticuli. In Quv quail electron micrographs of cochlear nerve myelinated fibers NFs were not seen in the axons and the neuronal cell bodies. Our current findings indicate that the previously reported reduction of conduction velocity of auditory evoked potentials may be due to smaller fiber and/or axonal diameter. The g-ratio, myelin thickness and fiber circularity were found to be the same for both strains. In conclusion, loss of axonal cytoskeletal elements (NFs) correlates well with our electrophysiological findings. Reduced conduction velocity and severely distorted auditory evoked potentials in NF deficient quails seem to be primarily due to axonal hypotrophy.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0378-5955(01)00326-4" target="_blank" rel="noreferrer noopener">10.1016/s0378-5955(01)00326-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Mutation
2001
Animals
Auditory
Axons/ultrastructure
Brain Stem
Cochlear Nerve/*pathology/*physiopathology
Coturnix/genetics
Electron
Evoked Potentials
Hearing research
Kaga K
Microscopy
Mizutani M
Myelin Sheath/ultrastructure
Nerve Fibers/pathology/physiology
Neurofilament Proteins/*deficiency/*genetics
Sheykholeslami K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0378-5955(00)00214-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-5955(00)00214-8</a>
Pages
95–105
Issue
1
Volume
151
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Topographical distribution of delay-tuned responses in the mustached bat inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-01
Subject
The topic of the resource
Acoustic Stimulation; Animals; Auditory Cortex/anatomy & histology/physiology; Chiroptera/*anatomy & histology/*physiology; Echolocation/physiology; Inferior Colliculi/*anatomy & histology/*physiology; Neurons/physiology; Ultrasonics
Creator
An entity primarily responsible for making the resource
Portfors C V; Wenstrup J J
Description
An account of the resource
In the mustached bat, delay-tuned neurons respond best to specific delays between the first harmonic frequency modulated (FM) component (FM1; 24-29 kHz) of the emitted biosonar pulse and a higher harmonic FM component in returning echoes (e.g. FM3, 72-89 kHz). These delay-tuned, combinatorial responses predominate in the inferior colliculus (IC) of the mustached bat. This study examined the topographical distribution of delay-tuned neurons in the 72-89 kHz frequency representation of the IC. We recorded and histologically localized 163 single units. Ninety units were facilitated and 41 were inhibited by the combination of two frequencies in the 24-29 kHz and 72-89 kHz ranges. The facilitatory responses were selective for delays up to 20 ms between the two signals. To determine if delay-tuned neurons were topographically organized, we plotted the dorsomedio-ventrolateral and caudo-rostral positions of each unit versus its best delay. Best delay was not correlated with either location. Response latency to best frequency tones was topographically organized, but was not correlated with best delay. This indicates that the latency axis in the IC is unrelated to the delay tuning of these combinatorial neurons. Because delay-tuned neurons are not topographically organized in the IC but are in the auditory cortex, our findings suggest that the creation and organization of delay-tuned neurons occur at different stages in the ascending auditory system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0378-5955(00)00214-8" target="_blank" rel="noreferrer noopener">10.1016/s0378-5955(00)00214-8</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Acoustic Stimulation
Animals
Auditory Cortex/anatomy & histology/physiology
Chiroptera/*anatomy & histology/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation/physiology
Hearing research
Inferior Colliculi/*anatomy & histology/*physiology
NEOMED College of Medicine
Neurons/physiology
Portfors C V
Ultrasonics
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2018.10.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2018.10.001</a>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Subtypes of GABAergic cells in the inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
Auditory system; Cell type; GABA; Inhibition; Perineuronal net
Creator
An entity primarily responsible for making the resource
Schofield Brett R; Beebe Nichole L
Description
An account of the resource
The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to numerous targets. A variety of types of evidence - morphology, physiology, molecular markers - indicate that the GABAergic cells can be divided into at least four subtypes that serve different functions. However, there has yet to emerge a unified scheme for distinguishing these subtypes. The present review discusses these criteria and, where possible, relates the different properties. In contrast to GABAergic cells in cerebral cortex, where subtypes are much more thoroughly characterized, those in the inferior colliculus contribute substantially to numerous long range extrinsic projections. At present, the best characterized subtype is a GABAergic cell with a large soma, dense perisomatic synaptic inputs and a large axon that provides rapid auditory input to the thalamus. This large GABAergic subtype projects to additional targets, and other subtypes also project to the thalamus. The eventual characterization of these subtypes can be expected to reveal multiple functions of these inhibitory cells and the many circuits to which they contribute.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2018.10.001" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2018.10.001</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Auditory system
Beebe Nichole L
Cell type
Department of Anatomy & Neurobiology
GABA
Hearing research
inhibition
NEOMED College of Medicine
perineuronal net
Schofield Brett R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2018.07.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2018.07.008</a>
Pages
88–96
Volume
367
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Detection of single mRNAs in individual cells of the auditory system.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-09
Subject
The topic of the resource
Cochlea; Immunohistochemistry; Inner hair cell; Outer hair cell; Single-molecule fluorescence in situ hybridization; Spiral ganglion neuron
Creator
An entity primarily responsible for making the resource
Salehi Pezhman; Nelson Charlie N; Chen Yingying; Lei Debin; Crish Samuel D; Nelson Jovitha; Zuo Hongyan; Bao Jianxin
Description
An account of the resource
Gene expression analysis is essential for understanding the rich repertoire of cellular functions. With the development of sensitive molecular tools such as single-cell RNA sequencing, extensive gene expression data can be obtained and analyzed from various tissues. Single-molecule fluorescence in situ hybridization (smFISH) has emerged as a powerful complementary tool for single-cell genomics studies because of its ability to map and quantify the spatial distributions of single mRNAs at the subcellular level in their native tissue. Here, we present a detailed method to study the copy numbers and spatial localizations of single mRNAs in the cochlea and inferior colliculus. First, we demonstrate that smFISH can be performed successfully in adult cochlear tissue after decalcification. Second, we show that the smFISH signals can be detected with high specificity. Third, we adapt an automated transcript analysis pipeline to quantify and identify single mRNAs in a cell-specific manner. Lastly, we show that our method can be used to study possible correlations between transcriptional and translational activities of single genes. Thus, we have developed a detailed smFISH protocol that can be used to study the expression of single mRNAs in specific cell types of the peripheral and central auditory systems.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2018.07.008" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2018.07.008</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Bao Jianxin
Chen Yingying
Cochlea
Crish Samuel D
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Hearing research
Immunohistochemistry
Inner hair cell
Lei Debin
Nelson Charlie N
Nelson Jovitha
NEOMED College of Medicine
NEOMED College of Pharmacy
Outer hair cell
Salehi Pezhman
Single-molecule fluorescence in situ hybridization
Spiral ganglion neuron
Zuo Hongyan
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2018.03.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2018.03.013</a>
Pages
119–135
Volume
363
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Addressing variability in the acoustic startle reflex for accurate gap detection assessment.
Publisher
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Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-06
Subject
The topic of the resource
Acoustic startle response magnitude; Circadian rhythm; Gap-induced prepulse inhibition of the acoustic startle reflex; Prepulse facilitation; Tinnitus
Creator
An entity primarily responsible for making the resource
Longenecker Ryan J; Kristaponyte Inga; Nelson Gregg L; Young Jesse W; Galazyuk Alexander V
Description
An account of the resource
The acoustic startle reflex (ASR) is subject to substantial variability. This inherent variability consequently shapes the conclusions drawn from gap-induced prepulse inhibition of the acoustic startle reflex (GPIAS) assessments. Recent studies have cast doubt as to the efficacy of this methodology as it pertains to tinnitus assessment, partially, due to variability in and between data sets. The goal of this study was to examine the variance associated with several common data collection variables and data analyses with the aim to improve GPIAS reliability. To study this the GPIAS tests were conducted in adult male and female CBA/CaJ mice. Factors such as inter-trial interval, circadian rhythm, sex differences, and sensory adaptation were each evaluated. We then examined various data analysis factors which influence GPIAS assessment. Gap-induced facilitation, data processing options, and assessments of tinnitus were studied. We found that the startle reflex is highly variable in CBA/CaJ mice, but this can be minimized by certain data collection factors. We also found that careful consideration of temporal fluctuations of the ASR and controlling for facilitation can lead to more accurate GPIAS results. This study provides a guide for reducing variance in the GPIAS methodology - thereby improving the diagnostic power of the test.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2018.03.013" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2018.03.013</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Acoustic startle response magnitude
Circadian Rhythm
Department of Anatomy & Neurobiology
Galazyuk Alexander V
Gap-induced prepulse inhibition of the acoustic startle reflex
Hearing research
Kristaponyte Inga
Longenecker Ryan J
Nelson Gregg L
NEOMED College of Medicine
Prepulse facilitation
Tinnitus
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2017.01.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2017.01.011</a>
Pages
14–24
Volume
346
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Metabotropic glutamate and GABA receptors modulate cellular excitability and glutamatergic transmission in chicken cochlear nucleus angularis neurons.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
*Cellular excitability; *GABA(B)R; *mGluR; *Neuromodulation; *Nucleus angularis; *Synaptic transmission; Action Potentials/drug effects; Animals; Chick Embryo; Cochlear Nucleus/cytology/*physiology; Excitatory Postsynaptic Potentials/drug effects; GABA-B Receptor Agonists/pharmacology; GABA-B/*physiology; Glutamic Acid/*physiology; Metabotropic Glutamate/agonists/classification/*physiology; Neurons/drug effects/physiology; Patch-Clamp Techniques; Receptors; Synaptic Transmission/drug effects
Creator
An entity primarily responsible for making the resource
Shi Wei; Lu Yong
Description
An account of the resource
Neurons in the avian cochlear nucleus angularis (NA) receive glutamatergic input from the auditory nerve, and GABAergic input from the superior olivary nucleus. Physiologically heterogeneous, NA neurons perform multiple functions including encoding sound intensity information. Using in vitro whole-cell patch recordings from acute brain slices and immunohistochemistry staining, we investigated neuromodulation mediated by metabotropic glutamate and GABA receptors (mGluRs and GABABRs) in NA neurons. Based on their intrinsic firing patterns in response to somatic current injections, NA neurons were classified into onset, damped, and tonic cells. Pharmacological activation of group II mGluRs, group III mGluRs, and GABABRs, by their respective agonists, suppressed the cellular excitability of non-onset firing NA neurons. Each of these agonists inhibited the glutamatergic transmission in NA neurons, in a cell type-independent manner. The frequency but not the amplitude of spontaneous release of glutamate was reduced by each of these agonists, suggesting that the modulation of the glutamatergic transmission was via presynaptic actions. Interestingly, activation of group I mGluRs increased cellular excitability and suppressed glutamatergic transmission in non-onset neurons. These results elaborate that auditory processing in NA neurons is subject to neuromodulation mediated by metabotropic receptors activated by native neurotransmitters released at NA.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2017.01.011" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2017.01.011</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cellular excitability
*GABA(B)R
*mGluR
*Neuromodulation
*Nucleus angularis
*Synaptic Transmission
2017
Action Potentials/drug effects
Animals
Chick Embryo
Cochlear Nucleus/cytology/*physiology
Department of Anatomy & Neurobiology
Excitatory Postsynaptic Potentials/drug effects
GABA-B Receptor Agonists/pharmacology
GABA-B/*physiology
Glutamic Acid/*physiology
Hearing research
Lu Yong
Metabotropic Glutamate/agonists/classification/*physiology
NEOMED College of Medicine
Neurons/drug effects/physiology
Patch-Clamp Techniques
Receptors
Shi Wei
Synaptic Transmission/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2016.12.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2016.12.008</a>
Pages
148–154
Volume
349
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Noise-induced cochlear synaptopathy: Past findings and future studies.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-06
Subject
The topic of the resource
*Auditory Perception; *Hearing; *Hearing loss; *Molecular approach; *Preclinical model; *Spiral ganglion; *Synaptic loss; *Synaptic Transmission; Animals; Auditory; Hair Cells; Hearing Loss; Hearing Tests; Humans; Inner/*pathology; Noise-Induced/diagnosis/*pathology/physiopathology/psychology; Noise/*adverse effects; Predictive Value of Tests; Psychoacoustics; Spiral Ganglion/*pathology/physiopathology; Synapses/*pathology
Creator
An entity primarily responsible for making the resource
Kobel Megan; Le Prell Colleen G; Liu Jennifer; Hawks John W; Bao Jianxin
Description
An account of the resource
For decades, we have presumed the death of hair cells and spiral ganglion neurons are the main cause of hearing loss and difficulties understanding speech in noise, but new findings suggest synapse loss may be the key contributor. Specifically, recent preclinical studies suggest that the synapses between inner hair cells and spiral ganglion neurons with low spontaneous rates and high thresholds are the most vulnerable subcellular structures, with respect to insults during aging and noise exposure. This cochlear synaptopathy can be "hidden" because this synaptic loss can occur without permanent hearing threshold shifts. This new discovery of synaptic loss opens doors to new research directions. Here, we review a number of recent studies and make suggestions in two critical future research directions. First, based on solid evidence of cochlear synaptopathy in animal models, it is time to apply molecular approaches to identify the underlying molecular mechanisms; improved understanding is necessary for developing rational, effective therapies against this cochlear synaptopathy. Second, in human studies, the data supporting cochlear synaptopathy are indirect although rapid progress has been made. To fully identify changes in function that are directly related this hidden synaptic damage, we argue that a battery of tests including both electrophysiological and behavior tests should be combined for diagnosis of "hidden hearing loss" in clinical studies. This new approach may provide a direct link between cochlear synaptopathy and perceptual difficulties.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2016.12.008" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2016.12.008</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Auditory Perception
*Hearing
*Hearing loss
*Molecular approach
*Preclinical model
*Spiral ganglion
*Synaptic loss
*Synaptic Transmission
2017
Animals
Auditory
Bao Jianxin
Department of Anatomy & Neurobiology
Hair Cells
Hawks John W
Hearing Loss
Hearing research
Hearing Tests
Humans
Inner/*pathology
Kobel Megan
Le Prell Colleen G
Liu Jennifer
NEOMED College of Medicine
Noise-Induced/diagnosis/*pathology/physiopathology/psychology
Noise/*adverse effects
Predictive Value of Tests
Psychoacoustics
Spiral Ganglion/*pathology/physiopathology
Synapses/*pathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2016.06.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2016.06.006</a>
Pages
80–93
Volume
339
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-09
Subject
The topic of the resource
*Audiometric functions; *Hearing loss; *Mouse; *Permanent threshold shift; *Sound exposure; *Temporary threshold shift; Acoustic Stimulation/*methods; Animal; Animals; Audiometry; Auditory; Auditory Threshold/*physiology; Brain Stem/*physiology; Evoked Potentials; Hearing; Inbred CBA; Male; Mice; Models; Noise; Prepulse Inhibition/*physiology; Pure-Tone/*methods; Reflex; Startle/*physiology
Creator
An entity primarily responsible for making the resource
Longenecker R J; Alghamdi F; Rosen M J; Galazyuk A V
Description
An account of the resource
The high prevalence of noise-induced and age-related hearing loss in the general population has warranted the use of animal models to study the etiology of these pathologies. Quick and accurate auditory threshold determination is a prerequisite for experimental manipulations targeting hearing loss in animal models. The standard auditory brainstem response (ABR) measurement is fairly quick and translational across species, but is limited by the need for anesthesia and a lack of perceptual assessment. The goal of this study was to develop a new method of hearing assessment utilizing prepulse inhibition (PPI) of the acoustic startle reflex, a commonly used tool that measures detection thresholds in awake animals, and can be performed on multiple animals simultaneously. We found that in control mice PPI audiometric functions are similar to both ABR and traditional operant conditioning audiograms. The hearing thresholds assessed with PPI audiometry in sound exposed mice were also similar to those detected by ABR thresholds one day after exposure. However, three months after exposure PPI threshold shifts were still evident at and near the frequency of exposure whereas ABR thresholds recovered to the pre-exposed level. In contrast, PPI audiometry and ABR wave one amplitudes detected similar losses. PPI audiometry provides a high throughput automated behavioral screening tool of hearing in awake animals. Overall, PPI audiometry and ABR assessments of the auditory system are robust techniques with distinct advantages and limitations, which when combined, can provide ample information about the functionality of the auditory system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2016.06.006" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2016.06.006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Audiometric functions
*Hearing loss
*Mouse
*Permanent threshold shift
*Sound exposure
*Temporary threshold shift
2016
Acoustic Stimulation/*methods
Alghamdi F
Animal
Animals
Audiometry
Auditory
Auditory Threshold/*physiology
Brain Stem/*physiology
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk A V
Hearing
Hearing research
Inbred CBA
Longenecker R J
Male
Mice
Models
NEOMED College of Medicine
Noise
Prepulse Inhibition/*physiology
Pure-Tone/*methods
Reflex
Rosen M J
Startle/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2015.07.002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2015.07.002</a>
Pages
59–66
Volume
328
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Canertinib induces ototoxicity in three preclinical models.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-10
Subject
The topic of the resource
Animals; Antineoplastic Agents/*adverse effects/pharmacology; Antitumor; Auditory; Canertinib; Carcinoma; Drug Screening Assays; Ear; Electrophysiology; ERBB; ErbB Receptors/*antagonists & inhibitors; Female; Hair Cells; Hearing Loss/*chemically induced; Hearing/*drug effects; Inbred C57BL; Inbred CBA; Lung Neoplasms/drug therapy; Male; Mice; Morpholines/*adverse effects/pharmacology; Neuregulin-1/metabolism; Non-small cell lung cancer; Non-Small-Cell Lung/drug therapy; NRG1; Ototoxicity; Outer hair cell; Outer/*drug effects; Signal Transduction/drug effects; Zebrafish
Creator
An entity primarily responsible for making the resource
Tang Jian; Qian Yi; Li Hui; Kopecky Benjamin J; Ding Dalian; Ou Henry C; DeCook Rhonda; Chen Xiaojie; Sun Zhenyu; Kobel Megan; Bao Jianxin
Description
An account of the resource
Neuregulin-1 (NRG1) ligand and its epidermal growth factor receptor (EGFR)/ERBB family regulate normal cellular proliferation and differentiation in many tissues including the cochlea. Aberrant NRG1 and ERBB signaling cause significant hearing impairment in mice. Dysregulation of the same signaling pathway in humans is involved in certain types of cancers such as breast cancer or non-small cell lung cancer (NSCLC). A new irreversible pan-ERBB inhibitor, canertinib, has been tested in clinical trials for the treatment of refractory NSCLC. Its possible ototoxicity was unknown. In this study, a significant dose-dependent canertinib ototoxicity was observed in a zebrafish model. Canertinib ototoxicity was further confirmed in two mouse models with different genetic backgrounds. The data strongly suggested an evolutionally preserved ERBB molecular mechanism underlying canertinib ototoxicity. Thus, these results imply that clinical monitoring of hearing loss should be considered for clinical testing of canertinib or other pan-ERBB inhibitors.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2015.07.002" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2015.07.002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Animals
Antineoplastic Agents/*adverse effects/pharmacology
Antitumor
Auditory
Bao Jianxin
Canertinib
Carcinoma
Chen Xiaojie
DeCook Rhonda
Department of Anatomy & Neurobiology
Ding Dalian
Drug Screening Assays
Ear
Electrophysiology
ERBB
ErbB Receptors/*antagonists & inhibitors
Female
Hair Cells
Hearing Loss/*chemically induced
Hearing research
Hearing/*drug effects
Inbred C57BL
Inbred CBA
Kobel Megan
Kopecky Benjamin J
Li Hui
Lung Neoplasms/drug therapy
Male
Mice
Morpholines/*adverse effects/pharmacology
NEOMED College of Medicine
Neuregulin-1/metabolism
Non-small cell lung cancer
Non-Small-Cell Lung/drug therapy
NRG1
Ototoxicity
Ou Henry C
Outer hair cell
Outer/*drug effects
Qian Yi
Signal Transduction/drug effects
Sun Zhenyu
Tang Jian
Zebrafish
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2013.10.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2013.10.003</a>
Pages
131–144
Volume
306
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Auditory cortical axons contact commissural cells throughout the guinea pig inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-12
Subject
The topic of the resource
AC; Animals; auditory cortex; Auditory Cortex/*physiology; Auditory Pathways/cytology; Axons/metabolism/*pathology; Brain Mapping; cortical layers; Fast Blue; FB; FD; Female; FG; Fluor0Ruby; fluorescein dextran; Fluorescence; FluoroGold; FR; G-; G+; GAD; GAD-immunonegative; GAD-immunopositive; GAD-neg; gamma-Aminobutyric Acid/metabolism; GB; Glutamate Decarboxylase/metabolism; glutamic acid decarboxylase; green RetroBeads; Guinea Pigs; I-VI; IC; IC central nucleus; IC dorsal cortex; IC lateral cortex; IC rostral cortex; ICc; ICd; IClc; ICrc; Inferior Colliculi/pathology/*physiology; inferior colliculus; Male; Mesencephalon/pathology; Microscopy; ps; pseudosylvian sulcus; rhinal sulcus; rs; white matter; wm
Creator
An entity primarily responsible for making the resource
Nakamoto Kyle T; Sowick Colleen S; Schofield Brett R
Description
An account of the resource
Projections from auditory cortex (AC) affect how cells in both inferior colliculi (IC) respond to acoustic stimuli. The large projection from the AC to the ipsilateral IC is usually credited with the effects in the ipsilateral IC. The circuitry underlying effects in the contralateral IC is less clear. The direct projection from the AC to the contralateral IC is relatively small. An unexplored possibility is that the large ipsilateral cortical projection contacts the substantial number of cells in the ipsilateral IC that project through the commissure to the contralateral IC. Apparent contacts between cortical boutons and commissural cells were identified in the left IC after injection of different fluorescent tracers into the left AC and the right IC. Commissural cells were labeled throughout the left IC, and many (23-34%) appeared to be contacted by cortical axons. In the central nucleus, both disc-shaped and stellate cells were contacted. Antibodies to glutamic acid decarboxylase (GAD) were used to identify GABAergic commissural cells. The majority (\textgreater86%) of labeled commissural cells were GAD-immunonegative. Despite low numbers of GAD-immunopositive commissural cells, some of these cells were contacted by cortical boutons. Nonetheless, most cortically contacted commissural cells were GAD-immunonegative (i.e., presumably glutamatergic). We conclude that auditory cortical axons contact primarily excitatory commissural cells in the ipsilateral IC that project to the contralateral IC. These corticocollicular contacts occur in each subdivision of the ipsilateral IC, suggesting involvement of commissural cells throughout the IC. This pathway - from AC to commissural cells in the ipsilateral IC - is a prime candidate for the excitatory effects of activation of the auditory cortex on responses in the contralateral IC. Overall this suggests that the auditory corticofugal pathway is integrated with midbrain commissural connections.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2013.10.003" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2013.10.003</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
AC
Animals
auditory cortex
Auditory Cortex/*physiology
Auditory Pathways/cytology
Axons/metabolism/*pathology
Brain Mapping
cortical layers
Department of Anatomy & Neurobiology
Fast Blue
FB
FD
Female
FG
Fluor0Ruby
fluorescein dextran
Fluorescence
FluoroGold
FR
G-
G+
GAD
GAD-immunonegative
GAD-immunopositive
GAD-neg
gamma-Aminobutyric Acid/metabolism
GB
Glutamate Decarboxylase/metabolism
glutamic acid decarboxylase
green RetroBeads
Guinea Pigs
Hearing research
I-VI
IC
IC central nucleus
IC dorsal cortex
IC lateral cortex
IC rostral cortex
ICc
ICd
IClc
ICrc
Inferior Colliculi/pathology/*physiology
inferior colliculus
Male
Mesencephalon/pathology
Microscopy
Nakamoto Kyle T
NEOMED College of Medicine
ps
pseudosylvian sulcus
rhinal sulcus
rs
Schofield Brett R
Sowick Colleen S
white matter
wm
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2010.12.019" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2010.12.019</a>
Pages
85–95
Issue
1
Volume
279
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholinergic cells of the pontomesencephalic tegmentum: connections with auditory structures from cochlear nucleus to cortex.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-09
Subject
The topic of the resource
Acetylcholine/metabolism; Animals; Auditory Cortex/pathology; Auditory Pathways; Axons/physiology; Cholinergic Agents/*metabolism; Cholinergic Fibers/*metabolism; Cochlear Nucleus/*physiology; Cognition Disorders; Guinea Pigs; Humans; Neurotransmitter Agents/metabolism; Prosencephalon/pathology; Rats; Tegmentum Mesencephali/metabolism/*physiology
Creator
An entity primarily responsible for making the resource
Schofield Brett R; Motts Susan D; Mellott Jeffrey G
Description
An account of the resource
Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea receives cholinergic innervation from the superior olivary complex. Much of the remainder of the auditory pathways receives innervation from the pedunculopontine and laterodorsal tegmental nuclei, two nuclei referred to collectively as the pontomesencephalic tegmentum (PMT). The PMT provides the major source of ACh to the auditory thalamus and the midbrain, and is a substantial source (in addition to the superior olivary complex) of ACh in the cochlear nucleus. Individual cholinergic cells in the PMT often have axon branches that innervate multiple auditory nuclei, including nuclei on both sides of the brain as well as nuclei at multiple levels of the auditory system. The auditory cortex has direct axonal projections to the PMT cells, including cholinergic cells that project to the inferior colliculus or cochlear nucleus. The divergent projections of PMT cholinergic cells suggest widespread effects on the auditory pathways. These effects are likely to include plasticity as well as novelty detection, sensory gating, reward behavior, arousal and attention. Descending projections from the forebrain, including the auditory cortex, are likely to provide a high level of cognitive input to these cholinergic effects. Dysfunction associated with the cholinergic system may play a role in disorders such as tinnitus and schizophrenia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2010.12.019" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2010.12.019</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Acetylcholine/metabolism
Animals
Auditory Cortex/pathology
Auditory Pathways
Axons/physiology
Cholinergic Agents/*metabolism
Cholinergic Fibers/*metabolism
Cochlear Nucleus/*physiology
Cognition Disorders
Department of Anatomy & Neurobiology
Guinea Pigs
Hearing research
Humans
Mellott Jeffrey G
Motts Susan D
NEOMED College of Medicine
Neurotransmitter Agents/metabolism
Prosencephalon/pathology
Rats
Schofield Brett R
Tegmentum Mesencephali/metabolism/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2007.06.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2007.06.009</a>
Pages
67–77
Issue
1
Volume
232
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Projections from auditory cortex contact ascending pathways that originate in the superior olive and inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-10
Subject
The topic of the resource
Animals; Auditory Cortex/*cytology; Auditory Pathways/*cytology; Fluorescence; Guinea Pigs; Inferior Colliculi/*cytology; Microscopy; Olivary Nucleus/*cytology; Staining and Labeling/methods
Creator
An entity primarily responsible for making the resource
Peterson Diana Coomes; Schofield Brett R
Description
An account of the resource
The superior olivary complex (SOC) and inferior colliculus (IC) are targets of cortical projections as well as sources of major ascending auditory pathways. This study examines whether the cortical projections contact cells in the SOC or IC that project to higher levels. First, we placed an anterograde tracer into the auditory cortex to label cortico-olivary axons and a retrograde tracer into the IC to label olivocollicular cells in guinea pigs. Cortical axons contacted many labeled cells in the ipsilateral SOC and fewer labeled cells in the contralateral SOC. Contacted cells projected to the ipsilateral or contralateral IC. In a second experiment, we labeled corticocollicular axons with an anterograde tracer and injected retrograde tracers into the medial geniculate (MG) to label colliculogeniculate cells. In the IC ipsilateral to the cortical injection, many cortical axons contacted colliculogeniculate cells in the dorsal cortex and external cortex of the IC. The contacted cells projected to the ipsilateral MG or, less often, to the contralateral MG. The results indicate that cortical projections are likely to contact cells in the SOC and IC that project to higher centers. This suggests that auditory cortex can modulate the ascending auditory pathways at multiple levels of the brainstem.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2007.06.009" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2007.06.009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Animals
Auditory Cortex/*cytology
Auditory Pathways/*cytology
Department of Anatomy & Neurobiology
Fluorescence
Guinea Pigs
Hearing research
Inferior Colliculi/*cytology
Microscopy
NEOMED College of Medicine
Olivary Nucleus/*cytology
Peterson Diana Coomes
Schofield Brett R
Staining and Labeling/methods
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.heares.2006.01.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2006.01.004</a>
Pages
81–89
Volume
216-217
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pathways from auditory cortex to the cochlear nucleus in guinea pigs.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-07
Subject
The topic of the resource
Animals; Auditory Cortex/*anatomy & histology/physiology; Auditory Pathways/anatomy & histology/physiology; Axons/physiology/ultrastructure; Cochlear Nucleus/*anatomy & histology/physiology; Efferent Pathways/*anatomy & histology/physiology; Efferent/physiology; Fluorescence; Fluorescent Dyes; Guinea Pigs; Inferior Colliculi/*anatomy & histology/physiology; Microscopy; Neurons; Olivary Nucleus/*anatomy & histology/physiology
Creator
An entity primarily responsible for making the resource
Schofield Brett R; Coomes Diana L
Description
An account of the resource
The inferior colliculus (IC) and superior olivary complex (SOC) are important sources of descending pathways to the cochlear nucleus. The IC and SOC are also targets of direct projections from the auditory cortex but it is not known if cortical axons contact the cells that project to the cochlear nucleus. Multi-labeling techniques were used to address this question in guinea pigs. A fluorescent anterograde tracer was injected into temporal cortex to label corticofugal axons. Different fluorescent tracers were injected into one or both cochlear nuclei to label olivary and collicular cells. The brain was subsequently processed for fluorescence microscopy and the IC and SOC were examined for apparent contacts between cortical axons and retrogradely labeled cells. The results suggest that cortical axons contact cochlear nucleus-projecting cells in both IC and SOC. In both regions, contacts were more numerous on the side ipsilateral to the injected cortex. In the IC, the contacted cells projected ipsilaterally or contralaterally to the CN. In the SOC, the contacted cells projected ipsilaterally, contralaterally or bilaterally to the CN. We conclude that auditory cortex is in a position to modulate descending pathways from both the IC and SOC to the cochlear nucleus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.heares.2006.01.004" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2006.01.004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Animals
Auditory Cortex/*anatomy & histology/physiology
Auditory Pathways/anatomy & histology/physiology
Axons/physiology/ultrastructure
Cochlear Nucleus/*anatomy & histology/physiology
Coomes Diana L
Department of Anatomy & Neurobiology
Efferent Pathways/*anatomy & histology/physiology
Efferent/physiology
Fluorescence
Fluorescent Dyes
Guinea Pigs
Hearing research
Inferior Colliculi/*anatomy & histology/physiology
Microscopy
NEOMED College of Medicine
Neurons
Olivary Nucleus/*anatomy & histology/physiology
Schofield Brett R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0378-5955(95)00164-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0378-5955(95)00164-x</a>
Pages
185–191
Issue
1
Volume
90
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Combination-sensitive neurons in the inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-10
Subject
The topic of the resource
Acoustic Stimulation; Animals; Auditory Cortex/metabolism; Chiroptera; Doppler; Inferior Colliculi/*cytology/metabolism; Neurons/cytology/*physiology; Sound Localization; Transcranial; Ultrasonography
Creator
An entity primarily responsible for making the resource
Mittmann D H; Wenstrup J J
Description
An account of the resource
We examined whether neurons in the inferior colliculus of the mustached bat (Pteronotus parnellii) are combination sensitive, responding to both low- and high-frequency components of the bat's sonar signal. These neurons, previously reported in the thalamus and cortex, analyze sonar target features including distance. Of 82 single units and 36 multiple units from the 58-112 kHz representations of the inferior colliculus, most (86%) displayed sensitivity to low-frequency sounds that was tuned in the range of the fundamental biosonar component (24-31 kHz). All histologically localized units were in the central nucleus of the inferior colliculus (ICC). There were two major types of combination-sensitive influences. Many neurons were facilitated by low-frequency sounds and selective for particular delays between the low- and high-frequency components. In other neurons, the low-frequency signal was inhibitory if presented simultaneously or a few milliseconds prior to the high-frequency signal. The results indicate that mechanisms creating specialized frequency comparisons and delay sensitivity in combination-sensitive neurons operate at the ICC or below. Since combination sensitivity or multipeaked tuning curves occur in the auditory systems of many species, ICC neurons in these animals may also respond to species-specific frequency combinations.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0378-5955(95)00164-x" target="_blank" rel="noreferrer noopener">10.1016/0378-5955(95)00164-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Acoustic Stimulation
Animals
Auditory Cortex/metabolism
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Doppler
Hearing research
Inferior Colliculi/*cytology/metabolism
Mittmann D H
NEOMED College of Medicine
Neurons/cytology/*physiology
Sound Localization
Transcranial
Ultrasonography
Wenstrup J J