1
40
29
-
Hyperlink
A link, or reference, to another resource on the Internet.
URL
10.3390/jcm12051799
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Title
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Precision Medicine and the future of Cardiovascular Diseases: A Clinically Oriented Comprehensive Review
Creator
An entity primarily responsible for making the resource
Yashendra Sethi
Neil Patel
Nirja Kaka
Oroshay Kaiwan
Jill Kar
Arsalan Moinuddin
Ashish Goel
Hitesh Chopra
Simona Cavalu
Date
A point or period of time associated with an event in the lifecycle of the resource
2023
Description
An account of the resource
Cardiac diseases form the lion's share of the global disease burden, owing to the paradigm shift to non-infectious diseases from infectious ones. The prevalence of CVDs has nearly doubled, increasing from 271 million in 1990 to 523 million in 2019. Additionally, the global trend for the years lived with disability has doubled, increasing from 17.7 million to 34.4 million over the same period. The advent of precision medicine in cardiology has ignited new possibilities for individually personalized, integrative, and patient-centric approaches to disease prevention and treatment, incorporating the standard clinical data with advanced "omics". These data help with the phenotypically adjudicated individualization of treatment. The major objective of this review was to compile the evolving clinically relevant tools of precision medicine that can help with the evidence-based precise individualized management of cardiac diseases with the highest DALY. The field of cardiology is evolving to provide targeted therapy, which is crafted as per the "omics", involving genomics, transcriptomics, epigenomics, proteomics, metabolomics, and microbiomics, for deep phenotyping. Research for individualizing therapy in heart diseases with the highest DALY has helped identify novel genes, biomarkers, proteins, and technologies to aid early diagnosis and treatment. Precision medicine has helped in targeted management, allowing early diagnosis, timely precise intervention, and exposure to minimal side effects. Despite these great impacts, overcoming the barriers to implementing precision medicine requires addressing the economic, cultural, technical, and socio-political issues. Precision medicine is proposed to be the future of cardiovascular medicine and holds the potential for a more efficient and personalized approach to the management of cardiovascular diseases, contrary to the standardized blanket approach.
Source
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J Clin Med
. 2023 Feb 23;12(5):1799. doi: 10.3390/jcm12051799.
Language
A language of the resource
English
2023
Cardiology
Heart failure
Hypertension
myocardial infarction
precision cardiology
Precision medicine
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Xiaoyu Jiangzhi capsule protects against heart failure via Ca2+/CaMKII signaling pathways in mice
Creator
An entity primarily responsible for making the resource
Wu, Jianwei
Tan, Yafang
Kang, Dongyuan
Yu, Juan
Qi, Jianyong
Wu, Jiashin
Zhang, Minzhou
Publisher
An entity responsible for making the resource available
Elsevier B.V.
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Description
An account of the resource
Objective Heart failure (HF), a worldwide health condition, is the result of many cardiovascular diseases. The traditional Chinese medicine (TCM) Xiaoyu Jiangzhi capsule (XYC) has long been in use in China to treat hyperlipidemia and inhibit platelet aggregation. This study explores the effects of XYC on heart failure (HF) and its detailed mechanisms.
Results XYC reduced HF, inhibiting the protein expression of CaMKII, but Serca did not change significantly. Moreover, XYC inhibited the peak amplitude of the hCaV1.2 current, depolarizing shifted the activation curve 27.6 mV, and shifted the inactivation curve toward a positive potential 17.6 mV. The fraction recovered from inaction was reduced in XYC group compared with that in CON group.
Conclusion XYC could inhibit ISO-induced HF by reducing the Ca2+/CaMKII signaling pathway in mice.
Source
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In Journal of Traditional Chinese Medical Sciences July 2022 9(3):289-297
Language
A language of the resource
English
2022
CaMKII
CaV1.2 channel
Heart failure
Mice
Patch clamp
Serca
Traditional Chinese medicine
Xiaoyu Jiangzhi capsule
-
Hyperlink
A link, or reference, to another resource on the Internet.
URL
https://doi.org/10.1016/j.cardfail.2021.11.011
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Proteome Dynamics and Bioinformatics Reveal Major Alterations in the Turnover Rate of Functionally Related Cardiac and Plasma Proteins in a Dog Model of Congestive Heart Failure
Creator
An entity primarily responsible for making the resource
Khatia Gabisonia
Gia Burjanadze
Felix Woitek
Ayse Keles
Mitsuru Seki
Nikoloz Gorgodze
Lucia Carlucci
Serguei Ilchenko
Clara Kurishima
Kenneth Walsh
Helen Piontkivska
Fabio A Recchia
Takhar Kasumov
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Description
An account of the resource
Protein pool turnover is a critically important cellular homeostatic component, yet it has been little explored in the context of heart failure (HF) pathophysiology. We used in vivo 2H labeling/proteome dynamics for the nonbiased discovery of turnover alterations involving functionally linked cardiac and plasma proteins in canine tachypacing-induced HF, an established preclinical model of dilated cardiomyopathy. Compared with controls, dogs with congestive HF displayed bidirectional turnover changes of 28 cardiac proteins, that is, a reduced half-life of several key enzymes involved in glycolysis, homocysteine metabolism and glycogenesis, and increased half-life of proteins involved in proteolysis. Changes in plasma proteins were more modest: only 5 proteins, involved in various functions including proteolysis inhibition, hemoglobin, calcium and ferric iron binding, displayed increased or decreased turnover rates. In other dogs undergoing cardiac tachypacing, we infused for 2 weeks the myokine Follistatin-like protein 1, known for its ameliorative effects on HF-induced alterations. Proteome dynamics proved very sensitive in detecting the partial or complete prevention, by Follistatin-like protein 1, of cardiac and plasma protein turnover alterations. In conclusion, our study unveiled, for the first time in a large mammal, numerous HF-related alterations that may serve as the basis for future mechanistic research and/or as conceptually new molecular markers.
Source
A related resource from which the described resource is derived
J Card Fail
. 2022 Apr;28(4):588-600. doi: 10.1016/j.cardfail.2021.11.011. Epub 2021 Nov 14.
Language
A language of the resource
English
2022
bioinformatics
Cardiac disease
Heart failure
Proteome dynamics
-
Hyperlink
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URL
https://doi.org/10.7759/cureus.29863
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Effect of COVID-19 on QTc Prolongation
Creator
An entity primarily responsible for making the resource
Isaac Alsallamin
Ewelina Skomorochow
Rami Musallam
Ameed Bawwab
Afnan Alsallamin
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Description
An account of the resource
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme-2 receptors on host cells to enter the cells. These receptors are expressed on heart muscle tissue and the tissues of other major organs, which supports the primary accepted theory for the direct cardiac cell injury of coronavirus disease 2019 (COVID-19) and the associated cardiorespiratory manifestations. The SARS-CoV-2 infection leads to unstable myocardial cell membranes due to hypoxia, myocarditis, myocardial ischemia, and abnormal host immune response. This is the main reason behind arrhythmia and electrocardiogram (ECG) changes during COVID-19. However, the specific effect on QTc has not been studied well. Therefore, this study aimed to examine the association between COVID-19 and QTc changes. Methodology We conducted an observational, retrospective review of hospital medical records of 320 adult participants diagnosed with COVID-19 at our facility. After applying the exclusion criteria, 130 participants were included and distributed into two groups. One group had long QTc, and one group had normal QTc. Data were collected and recorded using Microsoft Excel. We used SPSS Statistics for Windows, Version 20.0. (IBM Corp., Armonk, NY, USA) to analyze the data. Student's t-tests were performed for independent groups. Quantitative data were summarized using mean and standard deviation. Statistical significance was taken as p < 0.05. Results A total of 63 (48.4%) participants met the criteria for long QTc, and 67 (51.5%) participants had normal QTc (p < 0.001). There was no statistically significant difference in mortality outcomes between long QTc and normal QTc (0.8% vs. 3.8%, respectively; p = 0.21). Conclusions This study aimed to examine the association between COVID-19 and QTc changes. Nearly half of the participants had an increased QTc with COVID-19, and QTc length was not associated with mortality outcomes. Our results indicate that COVID-19 is an independent risk factor for QTc prolongation on ECG. Identifying COVID-19 as an independent risk factor for QTc prolongation is a clinically significant finding, and physicians should consider this when treating cardiac patients and possible COVID-19-positive patients.
Source
A related resource from which the described resource is derived
Cureus
. 2022 Oct 3;14(10):e29863. doi: 10.7759/cureus.29863. eCollection 2022 Oct.
Language
A language of the resource
English
2022
cardiac arrhythmia
COVID-19
ecg abnormalities
Heart failure
intraoperative arrhythmia
qtc prolongation.
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ehjci/ehaa946.1024" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ehjci/ehaa946.1024</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1024
Issue
2
Volume
41
ISSN
0195-668X
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Update Year & Number
February 2021 List
NEOMED College
NEOMED College of Medicine Student
NEOMED Department
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evidence of occult right ventricular dysfunction in morbidly obese patients
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11
Subject
The topic of the resource
obesity; Ventricular Dysfunction; endocardium; heart failure; pulmonary hypertension; Diagnostic Techniques; chronic heart failure; body mass index procedure; right-sided; right ventricular ejection fraction; myocardial dysfunction
Creator
An entity primarily responsible for making the resource
Kulifay SLKS;Lattanzio DSLD;Mikolich BMMB;Mikolich JRMR
Description
An account of the resource
Background Abnormalities of right ventricular (RV) strain have been shown to occur prior to impairment of global right ventricular function, measured by global RV ejection fraction (RVEF) in patients with increased RV afterload, such as pulmonary hypertension. Obesity is a form of increased afterload involving both the right and left cardiac circulations, raising suspicion that impaired RV strain may be an early indicator of myocardial dysfunction. Purpose This study was designed to assess impairment of RV strain in obese patients with normal right ventricular ejection fraction (RVEF) using cardiac MRI Fast SENC (strain encoded) pulse sequences. Methods An institutional cardiac imaging database was queried for all patients with body mass index (BMI) greater than 35 kg/m2 who underwent measurement of RV global longitudinal strain (GLS), RV global circumferential strain (GCS) and 37 segmental strain measurements using cardiac MRI Fast-SENC pulse sequences. Global RVEF was computed for all patients using a standard cardiac MRI method using non-automated hand drawn RV endocardial borders. Global and regional strain measurements were compared to a cohort of healthy volunteers who also underwent CMR Fast-SENC imaging. Abnormal myocardial strain was defined as a value greater than −17%. Results Of the 356 patients in the database, 48 had a BMI greater than 35 kg/m2. Mean RV GLS and GCS for the study cohort were −16.6 and −15.8 respectively. For healthy volunteers RV GLS and GCS were −20.8 and −19.0 respectively. Comparison of mean RV GLS and GCS of both groups were statistically significant ANOVA p<0.001. The number of normal RV segmental strain values was significantly decreased in obese patients when compared to the normal cohort, ANOVA p<0.001 (Figure 1). Furthermore, the prevalence of abnormal RV GCS in morbidly obese patients with normal RVEF greater than or equal to 40% was 84% (21 of 25 patients). Conclusions These findings suggest that morbidly many obese patients have occult RV dysfunction despite a normal RVEF. This occult RV dysfunction not only affects RV global GLS and GCS, but also the percentage of normal segmental strain values. Detection of occult RV dysfunction is of clinical significance in that it may provide an opportunity for treatment before development of symptomatic right heart failure.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ehjci/ehaa946.1024" target="_blank" rel="noreferrer noopener">10.1093/ehjci/ehaa946.1024</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
Publisher
An entity responsible for making the resource available
European Heart Journal
2020
body mass index procedure
chronic heart failure
Diagnostic Techniques
endocardium
European Heart Journal
February 2021 List
Heart failure
journalArticle
Kulifay SLKS
Lattanzio DSLD
Mikolich BMMB
Mikolich JRMR
myocardial dysfunction
NEOMED College of Medicine Student
NEOMED Student Publications
Obesity
pulmonary hypertension
right ventricular ejection fraction
right-sided
Ventricular Dysfunction
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3748/wjg.v26.i24.3413" target="_blank" rel="noreferrer noopener">http://doi.org/10.3748/wjg.v26.i24.3413</a>
Pages
3413-3420
Issue
24
Volume
26
ISSN
1007-9327
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3748/wjg.v26.i24.3413" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3748/wjg.v26.i24.3413</a>
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Radiology
Affiliated Hospital
Mercy Health St Elizabeth Boardman Hospital
Dublin Core
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Title
A name given to the resource
Ultrasound liver elastography beyond liver fibrosis assessment
Publisher
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World Journal of Gastroenterology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06-28
Subject
The topic of the resource
Heart failure; children; guidelines; Liver stiffness; Shear wave elastography; transient elastography; consensus; portal-hypertension; heart; Budd Chiari syndrome; central venous-pressure; congestion; fontan circulation; Fontan circulation; Hepatic sinusoidal obstruction syndrome; Liver congestion; stiffness measurements; Valvular diseases; Liver congestion
Creator
An entity primarily responsible for making the resource
Ferraioli G; Barr RG
Description
An account of the resource
Several guidelines have indicated that liver stiffness (LS) assessed by means of shear wave elastography (SWE) can safely replace liver biopsy in several clinical scenarios, particularly in patients with chronic viral hepatitis. However, an increase of LS may be due to some other clinical conditions not related to fibrosis, such as liver inflammation, acute hepatitis, obstructive cholestasis, liver congestion, infiltrative liver diseases. This review analyzes the role that SWE can play in cases of liver congestion due to right-sided heart failure, congenital heart diseases or valvular diseases. In patients with heart failure LS seems directly influenced by central venous pressure and can be used as a prognostic marker to predict cardiac events. The potential role of LS in evaluating liver disease beyond the stage of liver fibrosis has been investigated also in the hepatic sinusoidal obstruction syndrome (SOS) and in the Budd-Chiari syndrome. In the hepatic SOS, an increase of LS is observed some days before the clinical manifestations; therefore, it could allow an early diagnosis to timely start an effective treatment. Moreover, it has been reported that patients that were successfully treated showed a LS decrease, that reached pre-transplantation value within two to four weeks. It has been reported that, in patients with Budd-Chiari syndrome, LS values can be used to monitor short and long-term outcome after angioplasty.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3748/wjg.v26.i24.3413" target="_blank" rel="noreferrer noopener">10.3748/wjg.v26.i24.3413</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
August 2020 List
Barr RG
Budd Chiari syndrome
central venous-pressure
Children
congestion
Consensus
Department of Radiology
Ferraioli G
fontan circulation
guidelines
heart
Heart failure
Hepatic sinusoidal obstruction syndrome
journalArticle
Liver congestion
Liver stiffness
Mercy Health St Elizabeth Boardman Hospital
NEOMED College of Medicine
portal-hypertension
Shear wave elastography
stiffness measurements
transient elastography
Valvular diseases
World Journal of Gastroenterology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
Pages
15-20
Issue
3
Volume
31
ISSN
1557-2501
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: </a>
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Update Year & Number
June2020SubmittedList
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Outcomes among patients with heart failure with reduced ejection fraction undergoing transcatheter aortic valve replacement: Minimally invasive strategy versus conventional strategy.
Publisher
An entity responsible for making the resource available
The Journal of invasive cardiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
Female; Humans; Male; Aged; Retrospective Studies; Treatment Outcome; Prognosis; Cohort Studies; Severity of Illness Index; Aged 80 and over; Logistic Models; Survival Rate; Length of Stay; Multivariate Analysis; Risk Assessment; Reference Values; Hospital Mortality; aortic stenosis; transcatheter aortic valve replacement; heart failure; Transcatheter Aortic Valve Replacement/methods/mortality; anesthesia; conscious sedation; Aortic Valve Stenosis/diagnostic imaging/epidemiology/therapy; Cardiac Catheterization/methods; Cardiac Output Low/diagnostic imaging; Conscious Sedation/methods; Echocardiography Transesophageal/methods; Heart Failure/diagnosis/epidemiology/therapy; Minimally Invasive Surgical Procedures/methods; Surgery Computer-Assisted/methods
Creator
An entity primarily responsible for making the resource
Panhwar MS; Li J; Zidar DA; Clevenger J; Lipinski J; Patel TR; Karim A; Saric P; Patel SM; Kalra A; Attizzani GF
Description
An account of the resource
OBJECTIVES: To investigate the effect of TAVR technique on in-hospital and 30-day outcomes in patients with aortic stenosis (AS) and reduced ejection fraction (EF). BACKGROUND: Patients with AS and concomitant low EF may be at risk for adverse hemodynamic effects from general anesthesia utilized in transcatheter aortic valve replacement (TAVR) via the conventional strategy (CS). These patients may be better suited for the minimally invasive strategy (MIS), which employs conscious sedation. However, data are lacking that compare MIS to CS in patients with AS and concomitant low EF. METHODS: In this retrospective study, we identified all patients with low EF (<50%) undergoing transfemoral MIS-TAVR vs CS-TAVR between March 2011 and May 2018. Our primary endpoint was defined as the composite of in-hospital mortality and major periprocedural bleeding or vascular complications. RESULTS: Two hundred and seventy patients had EF <50%, while 154 patients had EF ≤35%. Overall, a total of 236 patients were in the MIS group and 34 were in the CS group. Baseline characteristics between the two groups were similar except for Society of Thoracic Surgeons (STS) score (MIS 8.4 ± 5.1 vs CS 11.7 ± 6.8; P<.01). There were no differences between the two groups in incidence of the primary endpoint (MIS 5.5% vs CS 8.8%; odds ratio for MIS, 0.60; 95% confidence interval, 0.16-2.23; P=.45). CONCLUSIONS: In patients with severe AS and reduced EF, MIS was not associated with adverse in-hospital or 30-day clinical outcomes compared with CS. In these patients, MIS may be a suitable alternative to CS without compromising clinical outcomes.
Identifier
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
PMID: 30555054
Rights
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Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2019
Aged
Aged 80 and over
Anesthesia
aortic stenosis
Aortic Valve Stenosis/diagnostic imaging/epidemiology/therapy
Attizzani GF
Cardiac Catheterization/methods
Cardiac Output Low/diagnostic imaging
Cleveland Clinic Akron General Hospital
Clevenger J
Cohort Studies
Conscious Sedation
Conscious Sedation/methods
Department of Internal Medicine
Echocardiography Transesophageal/methods
Female
Heart failure
Heart Failure/diagnosis/epidemiology/therapy
Hospital Mortality
Humans
journalArticle
June2020SubmittedList
Kalra A
Karim A
Length of Stay
Li J
Lipinski J
Logistic Models
Male
Minimally Invasive Surgical Procedures/methods
Multivariate Analysis
NEOMED College of Medicine
Panhwar MS
Patel SM
Patel TR
Prognosis
Reference Values
Retrospective Studies
Risk Assessment
Saric P
Severity of Illness Index
Surgery Computer-Assisted/methods
Survival Rate
The Journal of invasive cardiology
transcatheter aortic valve replacement
Transcatheter Aortic Valve Replacement/methods/mortality
Treatment Outcome
Zidar DA
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jchf.2018.10.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jchf.2018.10.011</a>
Pages
112-117
Issue
2
Volume
7
ISSN
2213-1787
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Update Year & Number
June2020SubmittedList
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of influenza on outcomes in patients with heart failure.
Publisher
An entity responsible for making the resource available
Journal of the American College of Cardiology. Heart failure
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-02
Subject
The topic of the resource
Female; Humans; Male; Aged; Retrospective Studies; Risk Factors; United States/epidemiology; Incidence; Follow-Up Studies; heart failure; hospitalization; Hospitalization/trends; vaccination; influenza; Survival Rate/trends; Risk Assessment/methods; Inpatients; Morbidity/trends; Hospital Mortality/trends; Propensity Score; Heart Failure/complications/epidemiology; Influenza Human/complications/epidemiology/prevention & control; Vaccination/methods
Creator
An entity primarily responsible for making the resource
Panhwar MS; Kalra A; Gupta T; Kolte D; Khera S; Bhatt DL; Ginwalla M
Description
An account of the resource
OBJECTIVES: This study sought to determine whether influenza infection increases morbidity and mortality in patients hospitalized with heart failure (HF). BACKGROUND: Patients with HF may be at increased risk of morbidity and mortality from influenza infection. However, there are limited data for the associated hazards of influenza infection in patients with HF. METHODS: We queried the 2013 to 2014 National Inpatient Sample database for all adult patients (18 years of age or older) admitted with HF with and without concomitant influenza infection. Propensity score matching was used to match patients across age, race, sex, and comorbidities. Outcomes included in-hospital mortality, in-hospital complications, length of stay, and average hospital costs. RESULTS: Of 8,189,119 all-cause hospitalizations in patients with HF, 54,590 (0.67%) had concomitant influenza infection. Patients with concomitant influenza had higher incidence of in-hospital mortality (6.2% vs. 5.4%, respectively; odds ratio [OR]: 1.15 [95% confidence interval [CI]: 1.03 to 1.30]; p = 0.02), acute respiratory failure (36.9% vs. 23.1%, respectively; OR: 1.95 [95% CI: 1.83 to 2.07]; p < 0.001), acute respiratory failure requiring mechanical ventilation (18.2% vs. 11.3%, respectively; OR: 1.75 [95% CI: 1.62 to 1.89]; p < 0.001), acute kidney injury (AKI) (30.3% vs. 28.7%, respectively; OR: 1.08 [95% CI: 1.02 to 1.15]; p = 0.01), and AKI requiring dialysis (2.4% vs. 1.8%, respectively; OR: 1.37 [95% CI: 1.14 to 1.65]; p = 0.001). Patients with influenza had longer mean lengths of stay (5.9 days vs. 5.2 days, respectively; p <0.001) but similar average hospital costs ($12,137 vs. $12,003, respectively; p = 0.40). CONCLUSIONS: Influenza infection is associated with increased in-hospital morbidity and mortality in patients with HF. Our results emphasize the need for efforts to mitigate the incidence of influenza, specifically in this high-risk patient cohort.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jchf.2018.10.011" target="_blank" rel="noreferrer noopener">10.1016/j.jchf.2018.10.011</a>
PMID: 30611718
Rights
Information about rights held in and over the resource
Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2019
Aged
Bhatt DL
Cleveland Clinic Akron General Hospital
Department of Internal Medicine
Female
Follow-Up Studies
Ginwalla M
Gupta T
Heart failure
Heart Failure/complications/epidemiology
Hospital Mortality/trends
Hospitalization
Hospitalization/trends
Humans
Incidence
Influenza
Influenza Human/complications/epidemiology/prevention & control
Inpatients
Journal of the American College of Cardiology. Heart failure
journalArticle
June2020SubmittedList
Kalra A
Khera S
Kolte D
Male
Morbidity/trends
NEOMED College of Medicine
Panhwar MS
Propensity Score
Retrospective Studies
Risk Assessment/methods
Risk Factors
Survival Rate/trends
United States/epidemiology
vaccination
Vaccination/methods
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="https://doi.org/10.1007/s11897-020-00476-w" target="_blank" rel="noreferrer noopener">https://doi.org/10.1007/s11897-020-00476-w</a>
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</div>
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Dublin Core
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Title
A name given to the resource
Evidence of Clonal Hematopoiesis and Risk of Heart Failure
Creator
An entity primarily responsible for making the resource
Peter Bazeley; Rommel Morales; W. H. Wilson Tang
Publisher
An entity responsible for making the resource available
Current Heart Failure Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
Description
An account of the resource
Purpose of Review
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by persistent clonal expansion of adult hematopoietic stem cells, which has been increasingly found to be associated with cardiovascular disease and adverse outcomes in heart failure. Here we outline emerging studies on the prevalence of CHIP, and its association with cardiovascular and heart disease.
Recent Findings
Previous genomic studies have found CHIP mutations to be associated with increased risks of arterial disease, stroke, and mortality. Murine studies exploring TET2, DNMT3A, and JAK2 mutations have shown changes in cellularity that decrease cardiac function after insult, as well as increase inflammasome activation.
Summary
Mutations in driver genes are associated with worse clinical outcomes in heart failure patients, as a potential result of the proinflammatory selection in clonal hematopoiesis. Advances in the field have yielded therapeutic targets tested in recent clinical studies and may provide a valuable diagnostic of risk in heart failure.
Subject
The topic of the resource
CHIP; Clonal hematopoiesis; Heart failure; Ten-eleven translocation-2; Janus kinase 2; Inflammasome
Identifier
An unambiguous reference to the resource within a given context
<a href="https://doi.org/10.1007/s11897-020-00476-w" target="_blank" rel="noreferrer noopener">10.1007/s11897-020-00476-w</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
CHIP
Cleveland Clinic
Clonal hematopoiesis
Current Heart Failure Reports
Heart failure
Inflammasome
Janus kinase 2
journalArticle
NEOMED College of Medicine Student
NEOMED Student Publications
Peter Bazeley
Rommel Morales
Ten-eleven translocation-2
W. H. Wilson Tang
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.14740/cr955" target="_blank" rel="noreferrer noopener">http://doi.org/10.14740/cr955</a>
Pages
76-88
Issue
2
Volume
11
ISSN
1923-2829 1923-2829
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
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Title
A name given to the resource
An Update on the Pathophysiology and Treatment of Cardiorenal Syndrome.
Publisher
An entity responsible for making the resource available
Cardiology research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
cardiac resynchronization therapy; Cardiorenal syndrome; cardiovascular events; Chronic kidney disease; Chronic kidney disease; decompensated heart-failure; Heart failure; impact; left-ventricular dysfunction; preserved ejection fraction; risk; vasopressin; worsening renal-function
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Nair Nikhil; Chakraborty Ronith; Nemer Lena; Dasgupta Rahul; Varian Kenneth
Description
An account of the resource
Cardiorenal syndrome (CRS) encompasses various disorders of the heart and kidneys; dysfunction of one organ leads to acute or chronic dysfunction of the other. It incorporates the intersection of heart-kidney interactions across several mediums, hemodynamically, through the alterations in neurohormonal markers, and increased venous and renal pressure, all of which are hallmarks of its clinical phenotypes. This article explores the epidemiology, pathology, classification and treatment of each type of CRS.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.14740/cr955" target="_blank" rel="noreferrer noopener">10.14740/cr955</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
cardiac resynchronization therapy
Cardiology research
Cardiorenal syndrome
cardiovascular events
Chakraborty Ronith
Chronic kidney disease
Cleveland Clinic Akron General Hospital
Dasgupta Rahul
decompensated heart-failure
Department of Internal Medicine
Heart failure
impact
Journal Article
journalArticle
June 2020 Update I
left-ventricular dysfunction
Nair Nikhil
Nemer Lena
NEOMED College of Medicine
preserved ejection fraction
Raina Rupesh
Risk
Varian Kenneth
vasopressin
worsening renal-function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00395-020-0775-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00395-020-0775-5</a>
Pages
14-14
Issue
2
Volume
115
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s00395-020-0775-5" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s00395-020-0775-5</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation.
Publisher
An entity responsible for making the resource available
Basic research in cardiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-01
Subject
The topic of the resource
Mechanotransduction; TRPV4; Myocardial infarction; Myocardial infarction; TGF-beta1; Rho/Rho kinase; Mechanotransduction; TGF-β1; Myocardial infarction; EXTRACELLULAR matrix; HEART failure; HEART fibrosis; HEART; Cardiac fibroblast; Cardiac fibrosis; Rho/Rho kinase; TRPV4; Cardiac fibroblast; Cardiac fibrosis; DELETION mutation
Creator
An entity primarily responsible for making the resource
Adapala Ravi K; Kanugula Anantha K; Paruchuri Sailaja; Chilian William M; Thodeti Charles K
Description
An account of the resource
Cardiac fibrosis caused by adverse cardiac remodeling following myocardial infarction can eventually lead to heart failure. Although the role of soluble factors such as TGF-beta is well studied in cardiac fibrosis following myocardial injury, the physiological role of mechanotransduction is not fully understood. Here, we investigated the molecular mechanism and functional role of TRPV4 mechanotransduction in cardiac fibrosis. TRPV4KO mice, 8 weeks following myocardial infarction (MI), exhibited preserved cardiac function compared to WT mice. Histological analysis demonstrated reduced cardiac fibrosis in TRPV4KO mice. We found that WT CF exhibited hypotonicity-induced calcium influx and extracellular matrix (ECM)-stiffness-dependent differentiation in response to
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00395-020-0775-5" target="_blank" rel="noreferrer noopener">10.1007/s00395-020-0775-5</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2020
Adapala Ravi K
Basic research in cardiology
cardiac fibroblast
Cardiac fibrosis
Chilian William M
DELETION mutation
Department of Integrative Medical Sciences
Extracellular Matrix
heart
Heart failure
HEART fibrosis
Kanugula Anantha K
Mechanotransduction
myocardial infarction
NEOMED College of Medicine
NEOMED Postdoc Publications
Paruchuri Sailaja
Rho/Rho kinase
TGF-beta1
TGF-β1
Thodeti Charles K
TRPV4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
36P-37P
Issue
43
ISSN
17496187
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Is heart failure a coronary microvascular disorder?
Publisher
An entity responsible for making the resource available
Proceedings Of The Physiological Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-01
Subject
The topic of the resource
HEART failure; MICROCIRCULATION disorders; COMPRESSIVE force; ENDOTHELIUM diseases
Creator
An entity primarily responsible for making the resource
Ohanyan V; Hakobyan T; Shockling L; Gyulkhasyan T; Enrick M; Kolz C L; Chilian W M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Chilian W M
COMPRESSIVE force
Department of Integrative Medical Sciences
ENDOTHELIUM diseases
Enrick M
Gyulkhasyan T
Hakobyan T
Heart failure
Journal Article
Kolz C L
MICROCIRCULATION disorders
NEOMED College of Medicine
November 2019 Update
Ohanyan V
Proceedings Of The Physiological Society
Shockling L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Issue
22
Volume
128
Search for Full-text
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Dublin Core
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Title
A name given to the resource
Early Up-regulation Of Myocardial Cxcr4 Expression Is Critical For Cardiac Improvement With Chemical Preconditioning In Acute Myocardial Infarction
Publisher
An entity responsible for making the resource available
Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-11
Subject
The topic of the resource
Cardiac regeneration; Cardiovascular System & Cardiology; heart failure; Myocardial infarction
Creator
An entity primarily responsible for making the resource
Kamath M; Kiedrowski M; Weber K; Forudi F; Penn M S; Dong F
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Cardiac regeneration
Cardiovascular System & Cardiology
Circulation
Dong F
Forudi F
Heart failure
Journal Article or Conference Abstract Publication
Kamath M
Kiedrowski M
myocardial infarction
Penn M S
Weber K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.109.3.756" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.109.3.756</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
756-760
Issue
3
Volume
109
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Title
A name given to the resource
Dopexamine Hydrochloride In Septic Shock
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
The topic of the resource
consumption; dobutamine; dopexamine hydrochloride; endotoxic dogs; General & Internal Medicine; heart failure; infusion; inotropic support; lactate; muscle; O-2 transport; O-2 uptake; optimal values; oxygen delivery; Respiratory System; respiratory-distress syndrome; sepsis; septic shock; tissue oxygenation; volume support
Creator
An entity primarily responsible for making the resource
Hannemann L; Reinhart K; Meierhellmann A; Wallenfang G; Bredle D L
Description
An account of the resource
Objective: To test whether dopexamine hydrochloride, by its beta(2)-adrenoceptor and dopaminergic 1 (DA(1)) and dopaminergic 2 (DA(2)) agonistic properties, can improve oxygen consumption (V over dot O-2) in hyperdynamic patients with septic shock. Design: Prospective, single-cohort study. Setting: ICU, university hospital. Patients: Twenty-nine postoperative, hemodynamically stabilized, hyperdynamic patients with septic shock. Interventions: Short-term application (30 min) of dopexamine hydrochloride at a dose of 2 mu g/kg/min. Measurements: Complete hemodynamic profile with O-2 transport-related variables at baseline, 30 min after starting the dopexamine infusion, and 30 min after stopping the infusion. Main results: The dopexamine infusion resulted in significant increases in cardiac index (17%) (p<0.001) and O-2 delivery (DO2) (16%) (p<0.001), V over dot O-2 increased slightly but significantly about 4% (p<0.01) by respiratory gas exchange measurements and 9% (p<0.01) by cardiovascular Fick calculations. The O-2 extraction ratio decreased about 8% (0.001). Conclusions: The addition of dopexamine hydrochloride at a dose of 2 mu g/kg/min resulted in significant increases of DO2 and to a lesser extent V over dot O-2. Much of the global DO2 increase was not utilized, because O-2 extraction ratio decreased. Direct calorigenic effects of dopexamine and an increase in myocardial V over dot O-2 likely account for a large portion of the increase in global V over dot O-2. Whether any of the V over dot O-2 increase reflects improvement in regions of jeopardized tissue oxygenation remains to be clarified before the definite value of this lug in septic shock can be established.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.109.3.756" target="_blank" rel="noreferrer noopener">10.1378/chest.109.3.756</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Bredle D L
Chest
consumption
dobutamine
dopexamine hydrochloride
endotoxic dogs
General & Internal Medicine
Hannemann L
Heart failure
infusion
inotropic support
Journal Article or Conference Abstract Publication
lactate
Meierhellmann A
Muscle
O-2 transport
O-2 uptake
optimal values
oxygen delivery
Reinhart K
Respiratory System
respiratory-distress syndrome
sepsis
Septic shock
tissue oxygenation
volume support
Wallenfang G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Issue
21
Volume
124
Search for Full-text
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Dublin Core
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Title
A name given to the resource
Targeting Mitochondrial Dna To Reduce Consequences Of Oxidative Stress: Role In The Prevention Of The Diabetic Cardiomyopathy
Publisher
An entity responsible for making the resource available
Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
arrhythmias; Cardiovascular System & Cardiology; Coronary circulation; Coronary microcirculation; heart failure; Mitochondrial energetics; oxidative stress; Type 2 Diabetes
Creator
An entity primarily responsible for making the resource
Guarini G; Kolz C L; Pung Y F; Ohanyan V A; Yin L Y; Bratz I N; Marzilli M; Chilian W M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
Arrhythmias
Bratz I N
Cardiovascular System & Cardiology
Chilian W M
Circulation
Coronary Circulation
Coronary microcirculation
Guarini G
Heart failure
Journal Article or Conference Abstract Publication
Kolz C L
Marzilli M
Mitochondrial energetics
Ohanyan V A
Oxidative Stress
Pung Y F
Type 2 diabetes
Yin L Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Issue
21
Volume
122
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role Of Mitochondrial Function And Mitochondrial Dna Integrity In Coronary Metabolic Dilation
Publisher
An entity responsible for making the resource available
Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-11
Subject
The topic of the resource
arrhythmias; Cardiovascular System & Cardiology; Coronary circulation; Coronary microcirculation; energetics; heart failure; Mitochondrial
Creator
An entity primarily responsible for making the resource
Guarini G; Kolz C; Ohanyan V A; Bratz I N; Yin L Y; Shokolenko I; Wilson G L; Chilian W M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2010
Arrhythmias
Bratz I N
Cardiovascular System & Cardiology
Chilian W M
Circulation
Coronary Circulation
Coronary microcirculation
energetics
Guarini G
Heart failure
Journal Article or Conference Abstract Publication
Kolz C
Mitochondrial
Ohanyan V A
Shokolenko I
Wilson G L
Yin L Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1042/cs20070160" target="_blank" rel="noreferrer noopener">http://doi.org/10.1042/cs20070160</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
357-364
Issue
7
Volume
113
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Dublin Core
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Title
A name given to the resource
Ace2 Overexpression Inhibits Hypoxia-induced Collagen Production By Cardiac Fibroblasts
Publisher
An entity responsible for making the resource available
Clinical Science
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-10
Subject
The topic of the resource
angiotensin-converting enzyme 2 (ACE2); angiotensin-converting enzyme-2; collagen; cross-talk; expression; fibroblast; growth-factor-beta; heart failure; hypoxia; Myocardial infarction; myofibroblast differentiation; oxidative stress; pathways; rat; remodelling; Research & Experimental Medicine; signaling; transforming growth factor beta (TGF beta)
Creator
An entity primarily responsible for making the resource
Grobe J L; Der Sarkissian S; Stewart J M; Meszaros J G; Raizada M K; Katovich M J
Description
An account of the resource
Cardiac remodelling is a key risk factor for the development of heart failure in the chronic phase following myocardial infarction. Our previous studies have shown an anti-remodelling role of ACE2 (angiotensin-converting enzyme 2) in vivo during hypertension and that these protective effects are mediated through increased circulating levels of Ang-(1-7) [angiotensin-(1-7)]. In the present study, we have demonstrated that cardiac myocytes have modest ACE2 activity, whereas cardiac fibroblasts do not: exhibit any endogenous activity. As fibroblasts are the major cell type found in an infarct zone following a myocardial infarction, we examined the effects of ACE2 gene delivery to cultured cardiac fibroblasts after acute hypoxic exposure. Cardiac fibroblasts from 5-day-old Sprague-Dawley rat hearts were grown to confluence and transduced with a lentiviral vector containing murine ACE2 cDNA under transcriptional control by the EFI alpha (elongation factor I alpha) promoter (lenti-ACE2). Transduction of fibroblasts with lenti-ACE2 resulted in a viral dose-dependent increase in ACE2 activity. This was associated with a significant attenuation of both basal and hypoxia/re-oxygenation-induced collagen production by the fibroblasts. Cytokine production, specifically TGF beta (transforming growth factor beta), by these cells was also significantly attenuated by ACE2 expression. Collectively, these results indicate that: (i) endogenous ACE2 activity is observed in cardiac myocytes, but not in cardiac fibroblasts; (ii) ACE2 overexpression in the cardiac fibroblast attenuates collagen production; and (iii) this prevention is probably mediated by decreased expression of cytokines. We conclude that ACE2 expression, limited to cardiac fibroblasts, may represent a novel paradigm for in vivo therapy following acute ischaemia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1042/cs20070160" target="_blank" rel="noreferrer noopener">10.1042/cs20070160</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
angiotensin-converting enzyme 2 (ACE2)
angiotensin-converting enzyme-2
Clinical Science
Collagen
cross-talk
Der Sarkissian S
expression
fibroblast
Grobe J L
growth-factor-beta
Heart failure
hypoxia
Journal Article or Conference Abstract Publication
Katovich M J
Meszaros J G
myocardial infarction
myofibroblast differentiation
Oxidative Stress
pathways
Raizada M K
rat
remodelling
Research & Experimental Medicine
Signaling
Stewart J M
transforming growth factor beta (TGF beta)
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Issue
3
Volume
62
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Novel role of Aminopeptidase A enzyme in Ang-(1-7) metabolism Post Myocardial Infarction
Publisher
An entity responsible for making the resource available
Hypertension
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-09
Subject
The topic of the resource
Aminopeptidase A; Angiotensin (1-7); Cardiovascular System & Cardiology; Heart Failure
Creator
An entity primarily responsible for making the resource
Alghamri M; Grobe N; Elased K; Meszaros G; Luther D; Morris M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Alghamri M
Aminopeptidase A
Angiotensin (1-7)
Cardiovascular System & Cardiology
Elased K
Grobe N
Heart failure
Hypertension
Journal Article or Conference Abstract Publication
Luther D
Meszaros G
Morris M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Issue
22
Volume
128
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Role of Vascular Smooth Muscle Kv 1.5 Channels in Coronary Metabolic Dilation
Publisher
An entity responsible for making the resource available
Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-11
Subject
The topic of the resource
Blood; Cardiovascular System & Cardiology; Coronary circulation; flow; Heart failure; Ion channels; Smooth muscle
Creator
An entity primarily responsible for making the resource
Ohanyan V A; Luli J; Yin L Y; Logan S; Enrick M; Stevanov K; Kolz C L; Kmetz J; Bratz I; Chilian W M
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
Blood
Bratz I
Cardiovascular System & Cardiology
Chilian W M
Circulation
Coronary Circulation
Enrick M
flow
Heart failure
Ion Channels
Journal Article
Kmetz J
Kolz C L
Logan S
Luli J
Ohanyan V A
smooth muscle
Stevanov K
Yin L Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Issue
21
Volume
126
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Title
A name given to the resource
Impaired Coronary Metabolic Dilation Leads to Heart Failure During Pressure Overload
Publisher
An entity responsible for making the resource available
Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-11
Subject
The topic of the resource
Aortic stenosis; Cardiovascular System & Cardiology; Coronary circulation; Heart failure; Ion channels; Potassium channel
Creator
An entity primarily responsible for making the resource
Ohanyan V A; Luther D; Kolz C; Logan S; Enrick M; Stevanov K; Yin L Y; Chilian W
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
aortic stenosis
Cardiovascular System & Cardiology
Chilian W
Circulation
Coronary Circulation
Enrick M
Heart failure
Ion Channels
Journal Article
Kolz C
Logan S
Luther D
Ohanyan V A
Potassium channel
Stevanov K
Yin L Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00421.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00421.2002</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
H176-H184
Issue
1
Volume
284
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Title
A name given to the resource
Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling
Publisher
An entity responsible for making the resource available
American Journal of Physiology-Heart and Circulatory Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-01
Subject
The topic of the resource
angiotensin-ii; Cardiovascular System & Cardiology; differentiation; fibrosis; gene-expression; Heart failure; identification; induction; Kirsten Ras; mineralocorticoid; mitogen-activated protein kinase; myofibroblast; na+ reabsorption; Physiology; receptor; spironolactone; transcription
Creator
An entity primarily responsible for making the resource
Stockand J D; Meszaros J G
Description
An account of the resource
Aldosterone plays a pathological role in cardiac fibrosis by directly affecting cardiac fibroblasts. Understanding of the cellular mechanisms of aldosterone action in cardiac fibroblasts, however, is rudimentary. One possibility is that aldosterone promotes proliferation of cardiac fibroblasts by activating specific cellular signaling cascades. The current study tests whether aldosterone stimulates proliferation of isolated adult rat cardiac myofibroblasts (RCF) by activating Kirsten Ras (Ki-RasA) and its effector, the MAPK1/2 cascade. Aldosterone (10 nM) significantly increased RCF proliferation. This action was sensitive to the mineralocorticoid receptor (MR) antagonist spironolactone. Expression of MR in RCF and the whole rat heart was confirmed by immunoblotting. Aldosterone significantly increased absolute and active (GTP bound) Ki-RasA levels in RCF. Aldosterone, in addition, significantly increased phospho-c-Raf and phospho-MAPK1/2. The effects of aldosterone on Ki-RasA and phospho-c-Raf proteins were inhibited by spironolactone but not RU-486, suggesting that aldosterone acts via MR. Inhibitors of MEK1/2 and c-Raf prevented aldosterone-induced activation of MAPK1/2 and proliferation. These results show that aldosterone directly increases RCF proliferation through MR-dependent activation of Ki-RasA and its effector, the MAPK1/2 cascade. Activation of cardiac fibroblasts through such a cascade may play a role in the pathological actions exerted by aldosterone on the heart.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00421.2002" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00421.2002</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2003
American Journal of Physiology-Heart and Circulatory Physiology
angiotensin-ii
Cardiovascular System & Cardiology
differentiation
Fibrosis
gene-expression
Heart failure
identification
induction
Journal Article
Kirsten Ras
Meszaros J G
mineralocorticoid
mitogen-activated protein kinase
myofibroblast
na+ reabsorption
Physiology
Receptor
spironolactone
Stockand J D
Transcription
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11606-013-2508-z" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11606-013-2508-z</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1353-1363
Issue
10
Volume
28
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Title
A name given to the resource
Stem Cell Therapy for Heart Disease
Publisher
An entity responsible for making the resource available
Journal of General Internal Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
acute myocardial-infarction; bone-marrow-cells; cardiac repair; cells; coronary-artery-disease; Function; General & Internal Medicine; Health Care Sciences & Services; Heart failure; intracoronary injection; ischemic-heart; left-ventricular; mononuclear-cells; myocardial infarction; paracrine; progenitor; randomized phase-1 trial; stem cell; ventricular function
Creator
An entity primarily responsible for making the resource
Puliafico S B; Penn M S; Silver K H
Description
An account of the resource
Coronary artery disease is the leading cause of death in Americans. After myocardial infarction, significant ventricular damage persists despite timely reperfusion and pharmacological management. Treatment is limited, as current modalities do not cure this damage. In the past decade, stem cell therapy has emerged as a promising therapeutic solution to restore myocardial function. Clinical trials have demonstrated safety and beneficial effects in patients suffering from acute myocardial infarction, heart failure, and dilated cardiomyopathy. These benefits include improved ventricular function, increased ejection fraction, and decreased infarct size. Mechanisms of therapy are still not clearly understood. However, it is believed that paracrine factors, including stromal cell-derived factor-1, contribute significantly to stem cell benefits. The purpose of this article is to provide medical professionals with an overview on stem cell therapy for the heart and to discuss potential future directions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11606-013-2508-z" target="_blank" rel="noreferrer noopener">10.1007/s11606-013-2508-z</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
acute myocardial-infarction
bone-marrow-cells
cardiac repair
Cells
coronary-artery-disease
Function
General & Internal Medicine
Health Care Sciences & Services
Heart failure
intracoronary injection
ischemic-heart
Journal Article
Journal of general internal medicine
left-ventricular
mononuclear-cells
myocardial infarction
paracrine
Penn M S
progenitor
Puliafico S B
randomized phase-1 trial
Silver K H
stem cell
Ventricular Function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/gt.2012.32" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/gt.2012.32</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
583-587
Issue
6
Volume
19
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Title
A name given to the resource
SDF-1 in myocardial repair
Publisher
An entity responsible for making the resource available
Gene Therapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-06
Subject
The topic of the resource
acute myocordial infarction; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; chemokines; gene-therapy; Genetics & Heredity; Heart failure; infarction; ischemic cardiomyopathy; mesenchymal stem-cells; pilot trial; regeneration; Regenerative medicine; Research & Experimental Medicine; stem-cells
Creator
An entity primarily responsible for making the resource
Penn M S; Pastore J; Miller T; Aras R
Description
An account of the resource
Stem cell therapy for the prevention and treatment of cardiac dysfunction holds significant promise for patients with ischemic heart disease. Excitingly early clinical studies have demonstrated safety and some clinical feasibility, while at the same time studies in the laboratory have investigated mechanisms of action and strategies to optimize the effects of regenerative cardiac therapies. One of the key pathways that has been demonstrated critical in stem cell-based cardiac repair is (stromal cell-derived factor-1) SDF-1:CXCR4. SDF-1:CXCR4 has been shown to affect stem cell homing, cardiac myocyte survival and ventricular remodeling in animal studies of acute myocardial infarction and chronic heart failure. Recently released clinical data suggest that SDF-1 alone is sufficient to induce cardiac repair. Most importantly, studies like those on the SDF-1:CXCR4 axis have suggested mechanisms critical for cardiac regenerative therapies that if clinical investigators continue to ignore will result in poorly designed studies that will continue to yield negative results. Gene Therapy (2012) 19, 583-587; doi:10.1038/gt.2012.32
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/gt.2012.32" target="_blank" rel="noreferrer noopener">10.1038/gt.2012.32</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
acute myocordial infarction
Aras R
Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
chemokines
gene therapy
gene-therapy
Genetics & Heredity
Heart failure
Infarction
ischemic cardiomyopathy
Journal Article
mesenchymal stem-cells
Miller T
Pastore J
Penn M S
pilot trial
Regeneration
Regenerative Medicine
Research & Experimental Medicine
stem-cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/circresaha.111.253427" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/circresaha.111.253427</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
304-+
Issue
2
Volume
110
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Title
A name given to the resource
Adventitial Delivery of an Allogeneic Bone Marrow-Derived Adherent Stem Cell in Acute Myocardial Infarction Phase I Clinical Study
Publisher
An entity responsible for making the resource available
Circulation Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
adventitia; Cardiovascular System & Cardiology; clinical-trial; double-blind; Heart failure; Hematology; myocardial infarction; progenitor cells; regeneration; stem-cells; transplantation
Creator
An entity primarily responsible for making the resource
Penn M S; Ellis S; Gandhi S; Greenbaum A; Hodes Z; Mendelsohn F O; Strasser D; Ting A E; Sherman W
Description
An account of the resource
Rationale: MultiStem is an allogeneic bone marrow-derived adherent adult stem cell product that has shown efficacy in preclinical models of acute myocardial infarction (AMI). In this phase I clinical trial in patients with first ST-elevation-myocardial infarction (STEMI), we combine first-in-man delivery of MultiStem with a first-in-coronary adventitial delivery system to determine the effects of this system on left ventricular function at 4 months after AMI. Objective: Test the effects of adventitial delivery of Multistem in the peri-infarct period in patients with first STEMI. Methods and Results: This study was a phase I, open-label, dose-escalating registry control group study. Nineteen patients received MultiStem (20 million, n=6; 50 million, n=7; or 100 million, n=6) and 6 subjects were assigned to the registry control group. Two to 5 days after AMI, we delivered MultiStem to the adventitia of the infarct-related vessel in patients with first-time STEMI. All patients underwent primary percutaneous coronary intervention with resulting Thrombolysis In Myocardial Infarction grade 3 flow and with ejection fraction (EF) <= 45% as determined by echocardiogram or left ventriculogram within 12 hours of primary percutaneous coronary intervention. The cell product (20 million, 50 million, or 100 million) was well tolerated, and no serious adverse events were deemed related to MultiStem. There was no increase in creatine kinase-MB or troponin associated with the adventitial delivery of MultiStem. In patients with EF determined to be <= 45% by a core laboratory within 24 hours before the MultiStem injection, we observed a 0.9 (n=4), 3.9 (n=4), 13.5 (n=5), and 10.9 (n=2) percent absolute increases in EF in the registry, 20 million, 50 million, and 100 million dose groups, respectively. The increases in EF in the 50 million and 100 million groups were accompanied by 25.4 and 8.4 mL increases in left ventricular stroke volume. Conclusions: In this study, the delivery of MultiStem to the myocardium in patients with recent STEMI was well tolerated and safe. In patients who exhibited significant myocardial damage, the delivery of >= 50 million MultiStem resulted in improved EF and stroke volume 4 months later. These findings support further development of MultiStem in patients with AMI and they validate the potential of a system for delivery of adult stem cells at any time after primary percutaneous coronary intervention. (Circ Res. 2012;110:304-311.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/circresaha.111.253427" target="_blank" rel="noreferrer noopener">10.1161/circresaha.111.253427</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
adventitia
Cardiovascular System & Cardiology
Circulation research
clinical-trial
double-blind
Ellis S
Gandhi S
Greenbaum A
Heart failure
Hematology
Hodes Z
Journal Article
Mendelsohn F O
myocardial infarction
Penn M S
progenitor cells
Regeneration
Sherman W
stem-cells
Strasser D
Ting A E
Transplantation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1074/jbc.M212659200" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.M212659200</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
24461-24468
Issue
27
Volume
278
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Title
A name given to the resource
Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin - G(q-)G(s) cross-talk regulates collagen production in cardiac fibroblasts
Publisher
An entity responsible for making the resource available
Journal of Biological Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-07
Subject
The topic of the resource
a(2b) receptors; adenosine inhibits collagen; Biochemistry & Molecular Biology; caveolae; Heart failure; in-vivo; nitric-oxide; pathway; protein-synthesis; smooth-muscle cells; ventricular myocytes
Creator
An entity primarily responsible for making the resource
Ostrom R S; Naugle J E; Hase M; Gregorian C; Swaney J S; Insel P A; Brunton L L; Meszaros J G
Description
An account of the resource
Cardiac fibroblasts regulate formation of extracellular matrix in the heart, playing key roles in cardiac remodeling and hypertrophy. In this study, we sought to characterize cross-talk between G(q) and G(s) signaling pathways and its impact on modulating collagen synthesis by cardiac fibroblasts. Angiotensin II (ANG II) activates cell proliferation and collagen synthesis but also potentiates cyclic AMP ( cAMP) production stimulated by beta-adrenergic receptors (beta-AR). The potentiation of beta-AR-stimulated cAMP production by ANG II is reduced by phospholipase C inhibition and enhanced by overexpression of G(q). Ionomycin and thapsigargin increased intracellular Ca2+ levels and potentiated isoproterenol- and forskolin-stimulated cAMP production, whereas chelation of Ca2+ with 1,2-bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid/AM inhibited such potentiation. Inhibitors of tyrosine kinases, protein kinase C, or Gbetagamma did not alter this cross-talk. Immunoblot analyses showed prominent expression of adenylyl cyclase 3 (AC3), a Ca2+-activated isoform, along with AC2, AC4, AC5, AC6, and AC7. Of those isoforms, only AC3 and AC5/6 proteins were detected in caveolin-rich fractions. Overexpression of AC6 increased betaAR-stimulated cAMP accumulation but did not alter the size of the ANG II potentiation, suggesting that the cross-talk is AC isoform-specific. Isoproterenol-mediated inhibition of serum-stimulated collagen synthesis increased from 31 to 48% in the presence of ANG II, indicating that betaAR-regulated collagen synthesis increased in the presence of ANG II. These data indicate that ANG II potentiates cAMP formation via Ca2+-dependent activation of AC activity, which in turn attenuates collagen synthesis and demonstrates one functional consequence of crosstalk between G(q) and G(s) signaling pathways in cardiac fibroblasts.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1074/jbc.M212659200" target="_blank" rel="noreferrer noopener">10.1074/jbc.M212659200</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2003
a(2b) receptors
adenosine inhibits collagen
Biochemistry & Molecular Biology
Brunton L L
caveolae
Gregorian C
Hase M
Heart failure
in-vivo
Insel P A
Journal Article
Journal of Biological Chemistry
Meszaros J G
Naugle J E
nitric-oxide
Ostrom R S
pathway
protein-synthesis
smooth-muscle cells
Swaney J S
ventricular myocytes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jamda.2015.05.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jamda.2015.05.006</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
825-831
Issue
10
Volume
16
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Title
A name given to the resource
Heart Failure in Post-Acute and Long-Term Care: Evidence and Strategies to Improve Transitions, Clinical Care, and Quality of Life
Publisher
An entity responsible for making the resource available
Journal of the American Medical Directors Association
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-10
Subject
The topic of the resource
2013 accf/aha guideline; association; cognitive impairment; discharge education; Emergency department; Geriatrics & Gerontology; Heart failure; hospitalized-patients; older patients; palliative care; post-acute care; scientific statement; skilled nursing facilities; task-force; transitional care
Creator
An entity primarily responsible for making the resource
Nazir A; Smucker W D
Description
An account of the resource
Heart failure (HF) is highly prevalent among older patients in skilled nursing facilities (SNFs). HF outcomes for SNF patients suffer because of many factors, including staff training, lack of physician availability, and failure to implement evidence-based care. AMDA - The Society for Post-Acute and Long-Term Care Medicine has recently updated the Clinical Practice Guidelines for Heart Failure Management in SNFs. This review supplements the Guidelines with a robust focus on best practices for transitional care, symptom management, treatment and monitoring, and palliative care in patients with HF. (C) 2015 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jamda.2015.05.006" target="_blank" rel="noreferrer noopener">10.1016/j.jamda.2015.05.006</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013 accf/aha guideline
2015
association
cognitive impairment
Department of Family & Community Medicine
discharge education
Emergency department
Geriatrics & Gerontology
Heart failure
hospitalized-patients
Journal Article
Journal of the American Medical Directors Association
Nazir A
NEOMED College of Medicine
older patients
Palliative Care
post-acute care
scientific statement
Skilled Nursing Facilities
Smucker W D
task-force
Transitional Care
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.14740/cr553w" target="_blank" rel="noreferrer noopener">http://doi.org/10.14740/cr553w</a>
Pages
87–95
Issue
3
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cardiorenal Syndrome: Role of Arginine Vasopressin and Vaptans in Heart Failure.
Publisher
An entity responsible for making the resource available
Cardiology research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-06
Subject
The topic of the resource
Arginine vasopressin; Cardiorenal syndrome; Conivaptan; Heart failure; Tolvaptan; Vaptans; Vasopressin receptor antagonists
Creator
An entity primarily responsible for making the resource
Vinod Poornima; Krishnappa Vinod; Chauvin Abigail M; Khare Anshika; Raina Rupesh
Description
An account of the resource
Heart and kidney failure continued to be of increasing prevalence in today's society, and their comorbidity has synergistic effect on the morbidity and mortality of patients. Cardiorenal syndrome (CRS) is a complex disease with multifactorial pathophysiology. Better understanding of this pathophysiological network is crucial for the successful intervention to prevent advancement of the disease process. One of the major factors in this process is neurohormonal activation, predominantly involving renin-angiotensin-aldosterone system (RAAS) and arginine vasopressin (AVP). Heart failure causes reduced cardiac output/cardiac index (CO/CI) and fall in renal perfusion pressures resulting in activation of baroreceptors and RAAS, respectively. Activated baroreceptors and RAAS stimulate the release of AVP (non-osmotic pathway), which acts on V2 receptors located in the renal collecting ducts, causing fluid retention and deterioration of heart failure. Effective blockade of AVP action on V2 receptors has emerged as a potential treatment option in volume overload conditions especially in the setting of hyponatremia. Vasopressin receptor antagonists (VRAs), such as vaptans, are potent aquaretics causing electrolyte-free water diuresis without significant electrolyte abnormalities. Vaptans are useful in hypervolemic hyponatremic conditions like heart failure and liver cirrhosis, and euvolemic hyponatremic conditions like syndrome of inappropriate anti-diuretic hormone secretion. Tolvaptan and conivaptan are pharmaceutical agents that are available for the treatment of these conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.14740/cr553w" target="_blank" rel="noreferrer noopener">10.14740/cr553w</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Arginine vasopressin
Cardiology research
Cardiorenal syndrome
Chauvin Abigail M
Conivaptan
Department of Internal Medicine
Heart failure
Khare Anshika
Krishnappa Vinod
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
Raina Rupesh
Tolvaptan
Vaptans
Vasopressin receptor antagonists
Vinod Poornima
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/CIRCRESAHA.116.309904" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/CIRCRESAHA.116.309904</a>
Pages
1075–1077
Issue
7
Volume
120
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Unraveling of the Matryoshka Doll.
Publisher
An entity responsible for making the resource available
Circulation research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
chemokines; exosomes; heart failure; myocardial infarction; stem cells
Creator
An entity primarily responsible for making the resource
Penn Marc S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/CIRCRESAHA.116.309904" target="_blank" rel="noreferrer noopener">10.1161/CIRCRESAHA.116.309904</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
chemokines
Circulation research
Exosomes
Heart failure
myocardial infarction
Penn Marc S
stem cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/20009666.2018.1454787" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/20009666.2018.1454787</a>
Pages
87–91
Issue
2
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rapidly progressive dyspnea in gastrointestinal stromal tumor (GIST) with imatinib cardiac toxicity.
Publisher
An entity responsible for making the resource available
Journal of community hospital internal medicine perspectives
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
cardiac toxicity; fluid retention; Gastrointestinal stromal tumors; GISTs; heart failure; imatinib; imatinib toxicity; LV dysfunction; rare
Creator
An entity primarily responsible for making the resource
Ghias Adnan Asif Parvez; Bhayani Shahzeem; Gemmel David J; Garg Sudershan K
Description
An account of the resource
Gastrointestinal stromal tumors (GISTs) are rare and current estimates range from 4,000 to 6,000 number of GIST cases in the USA annually. Imatinib, a tyrosine kinase inhibitor, has shown a survival benefit in GISTs, and the presence of KIT mutation status is predictive of response. The current case discusses rapidly progressive dyspnea and heart failure in an elderly male with metastatic GIST who was started on imatinib. Although reported as a rare and sporadic side effect of imatinib, the current case illustrates rapidity and the clinical significance of cardiotoxicity, with onset at 2 weeks. Cases of imatinib-induced cardiotoxicity can range from being mild ventricular dysfunction to overt heart failure. Prior to starting imatinib, our patient had a history of hypertension. He subsequently ended up developing heart failure as acknowledged by the echocardiogram (ECHO). In general, elderly with preexisting cardiovascular comorbidity are at greater risk. The goal in such situations is immediate discontinuation or reduction of the imatinib dosage. The case prompts for awareness of imatinib cardiotoxicity. Moreover, a pretreatment cardiac assessment along with monitoring throughout therapy is therefore advisable. Also, imatinib-induced cardiotoxicity should be differentiated from imatinib-associated fluid retention, in which ECHO findings can be normal. This case report raises the concern for accelerated cardiotoxicity profile of imatinib. Further prospective studies with multidisciplinary input are needed to establish this association further.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/20009666.2018.1454787" target="_blank" rel="noreferrer noopener">10.1080/20009666.2018.1454787</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Bhayani Shahzeem
cardiac toxicity
Department of Internal Medicine
fluid retention
Garg Sudershan K
Gastrointestinal stromal tumors
Gemmel David J
Ghias Adnan Asif Parvez
GISTs
Heart failure
imatinib
imatinib toxicity
Journal of community hospital internal medicine perspectives
LV dysfunction
NEOMED College of Medicine
rare