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40
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Text
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Pages
147–153
Issue
2
Volume
2
Dublin Core
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Title
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Malignant peripheral nerve sheath tumor at the cerebellopontine angle treated with Gamma Knife radiosurgery: case report and review of the literature.
Publisher
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Journal of radiosurgery and SBRT
Date
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2013
2013
Subject
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Cerebellopontine angle; Gamma Knife; Malignant peripheral nerve sheath tumor; Radiosurgery; Skull base; Stereotaxy
Creator
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Raper Daniel M S; Sweiss Fadi; Almira-Suarez M Isabel; Helm Gregory; Sheehan Jason P
Description
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BACKGROUND AND IMPORTANCE: Malignant peripheral nerve sheath tumor (MPNST) is a rare lesion that may arise de novo or develop from an existing benign neurofibroma. Very rarely, MPNST may develop from an existing schwannoma. Intracranial MPNST is rare, and most commonly affects thevestibulocochlear nerve. Surgery is the mainstay of treatment for these lesions, but gross total resection is often difficult given the proximity of adjacent neurovascular structures. Gamma knife radiosurgery (GKS) may represent a useful adjunct to subtotal resection or biopsy of these lesions, but its use for this tumor type has not been well defined. CLINICAL PRESENTATION: The patient, who had a long history of progressive sub-clinical hearing loss, presented with facial droop and decreased facial sensation. Imaging revealed a large left cerebellopontine angle tumor extending into the internal auditory canal. The mass was subtotally resected, and pathology revealed a malignant peripheral nerve sheath tumor. The patient underwent fractionated external beam radiotherapy two months later to the resection cavity, followed by Gamma Knife radiosurgery (GKRS) to the residual tumor. Follow up imaging eight months after GKRS revealed a substantial reduction in tumor size. The patient has remained clinically stable. CONCLUSION: GKS may be a useful adjunct to multimodality treatment for malignant tumors of the CPA, such as MPNST, after subtotal resection and/or radiotherapy. Close ongoing follow up with periodic MR imaging is essential to monitor for recurrence.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Almira-Suarez M Isabel
Cerebellopontine angle
Gamma Knife
Helm Gregory
Journal of radiosurgery and SBRT
Malignant peripheral nerve sheath tumor
Radiosurgery
Raper Daniel M S
Sheehan Jason P
Skull base
Stereotaxy
Sweiss Fadi